TNFR2

Understanding Entity Pages

This page aggregates everything SciDEX knows about TNFR2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

TNFR2 is a protein involved in neurodegeneration research. Key relationships include: regulates, associated with, expressed in. Associated with ALS, Aging, Als. Connected to 67 entities in the SciDEX knowledge graph.

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graph TD
    TNFR2["<b>TNFR2</b>"]
    ASTROCYTES["ASTROCYTES"]
    TNFR2 -->|"expressed in"| ASTROCYTES
    SYNAPTIC_FUNCTION["SYNAPTIC_FUNCTION"]
    TNFR2 -->|"regulates"| SYNAPTIC_FUNCTION
    SYNAPTIC_PLASTICITY["SYNAPTIC_PLASTICITY"]
    TNFR2 -->|"regulates"| SYNAPTIC_PLASTICITY
    Tumor{"Tumor"}
    TNFR2 -->|"regulates"| Tumor
    Als{"Als"}
    TNFR2 -->|"expressed in"| Als
    Cardiovascular{"Cardiovascular"}
    TNFR2 -->|"inhibits"| Cardiovascular
    TNFR2 -->|"inhibits"| Als
    TNFR2 -->|"inhibits"| Tumor
    Hypertension{"Hypertension"}
    TNFR2 -->|"inhibits"| Hypertension
    Ms{"Ms"}
    TNFR2 -->|"associated with"| Ms
    ALS{"ALS"}
    TNFR2 -->|"expressed in"| ALS
    TNFR1["TNFR1"]
    TNFR2 -->|"expressed in"| TNFR1
    TNF["TNF"]
    TNF -->|"activates"| TNFR2
    GFAP["GFAP"]
    GFAP -->|"regulates"| TNFR2
    TNF -->|"regulates"| TNFR2
    SOD2["SOD2"]
    SOD2 -->|"associated with"| TNFR2
    CAT["CAT"]
    CAT -->|"associated with"| TNFR2
    BAX["BAX"]
    BAX -->|"associated with"| TNFR2
    SPR["SPR"]
    SPR -->|"associated with"| TNFR2
    PPARGC1A["PPARGC1A"]
    PPARGC1A -->|"associated with"| TNFR2
    CASP3["CASP3"]
    CASP3 -->|"associated with"| TNFR2
    PDK1["PDK1"]
    PDK1 -->|"associated with"| TNFR2
    PDK4["PDK4"]
    PDK4 -->|"associated with"| TNFR2
    SOD1["SOD1"]
    SOD1 -->|"associated with"| TNFR2
    style TNFR2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0