concept

SEVOFLURANE

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SEVOFLURANE: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

0Hypotheses

1Analyses

22Outgoing

1Incoming

0Experiments

1Debates

No summary available yet.

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💡 Concept Info

Name	SEVOFLURANE
Related Pathways	NLRP3 inflammasome

Pathway Diagram

graph TD
    SEVOFLURANE[SEVOFLURANE]
    SEVOFLURANE -->|causes| Neurotoxicity[Neurotoxicity]
    SEVOFLURANE -->|activates| NLRP3[NLRP3]
    SEVOFLURANE -->|causes| Neurocognitive_Dysfunction[Neurocognitive Dysfunction]
    SEVOFLURANE -->|causes| Postoperative_Cognitive_Dysfun[Postoperative Cognitive Dysfunction]
    SEVOFLURANE -->|causes| Neuroinflammation[Neuroinflammation]
    SEVOFLURANE -->|activates| NF__B[NF-κB]
    SEVOFLURANE -->|promotes| microglia_activation[microglia activation]
    SEVOFLURANE -->|activates| NLRP3_inflammasome[NLRP3 inflammasome]
    SEVOFLURANE -->|downregulates| SYNAPTIC_GENES[SYNAPTIC GENES]
    SEVOFLURANE -->|causes| neuroinflammation[neuroinflammation]
    Synaptic_Gene_Expression[Synaptic Gene Expression] -->|downregulates| SEVOFLURANE

Outgoing (22)

Target	Relation	Type	Str
NLRP3	activates	protein	0.95
Neurotoxicity	causes	phenotype	0.95
Postoperative Cognitive Dysfunction	causes	disease	0.95
Neuroinflammation	causes	process	0.95
NF-κB	activates	pathway	0.95
Neurocognitive Dysfunction	causes	disease	0.95
NF-κB pathway	activates	pathway	0.90
NF-κB Signaling Pathway	activates	pathway	0.90
IL-1β expression	activates	phenotype	0.90
microglia activation	promotes	process	0.90
neuroinflammation	causes	process	0.90
NLRP3 inflammasome	activates	pathway	0.90
SYNAPTIC GENES	downregulates	gene	0.90
Reactive oxygen species	causes	phenotype	0.90
Mitochondrial Fission	associated_with	process	0.85
Neuronal Excitability	inhibits	phenotype	0.85
STING	activates	protein	0.75
microglial pro-inflammatory phenotype	causes	phenotype	0.70
IL-1β elevation	causes	process	0.70
microglial neuroinflammation	causes	phenotype	0.70
Il-1Β	causes	protein	0.70
Microglial Pro-Inflammatory State	causes	phenotype	0.70

Incoming (1)

Source	Relation	Type	Str
Synaptic Gene Expression	downregulates	process	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does sevoflurane-induced NF-κB activation specifically trigger complement ca

neuroinflammation | 2026-04-08 | 5 hypotheses Top: 0.658

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

While the study demonstrates both NF-κB pathway activation and increased C1qa ex

closed · Rounds: 4 · Score: 0.74 · 2026-04-21

Related Research

Hypotheses and analyses mentioning SEVOFLURANE in their description or question text

No additional research found