Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about POSTOPERATIVE COGNITIVE DYSFUNCTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | POSTOPERATIVE COGNITIVE DYSFUNCTION |
graph TD
POSTOPERATIVE_COGNITIVE_DYSFUN["POSTOPERATIVE COGNITIVE DYSFUNCTION"]
POSTOPERATIVE_COGNITIVE_DYSFUN -->|"causes"| Cognitive_Decline["Cognitive Decline"]
POSTOPERATIVE_COGNITIVE_DYSFUN -->|"risk_factor_for"| Alzheimer_s_Disease["Alzheimer's Disease"]
POSTOPERATIVE_COGNITIVE_DYSFUN -->|"causes"| Neuroinflammation["Neuroinflammation"]
POSTOPERATIVE_COGNITIVE_DYSFUN -->|"causes"| Oxidative_Stress["Oxidative Stress"]
POSTOPERATIVE_COGNITIVE_DYSFUN -->|"risk_factor_for"| Alzheimer_S_Disease["Alzheimer'S Disease"]
Sevoflurane["Sevoflurane"] -->|"causes"| POSTOPERATIVE_COGNITIVE_DYSFUN
Neuroinflammation -->|"causes"| POSTOPERATIVE_COGNITIVE_DYSFUN
Astrocytes["Astrocytes"] -->|"involved_in"| POSTOPERATIVE_COGNITIVE_DYSFUN
Oxidative_Stress -->|"causes"| POSTOPERATIVE_COGNITIVE_DYSFUN
Itaconate["Itaconate"] -->|"treats"| POSTOPERATIVE_COGNITIVE_DYSFUN
RU_521["RU.521"] -->|"treats"| POSTOPERATIVE_COGNITIVE_DYSFUN
neuroinflammation["neuroinflammation"] -->|"causes"| POSTOPERATIVE_COGNITIVE_DYSFUN
apoptosis["apoptosis"] -->|"causes"| POSTOPERATIVE_COGNITIVE_DYSFUN| Target | Relation | Type | Str |
|---|---|---|---|
| Neuroinflammation | associated_with | process | 0.95 |
| Oxidative Stress | associated_with | process | 0.95 |
| Cognitive Decline | causes | phenotype | 0.95 |
| Alzheimer's Disease | risk_factor_for | disease | 0.90 |
| Neuroinflammation | causes | process | 0.90 |
| Oxidative Stress | causes | process | 0.90 |
| Alzheimer'S Disease | risk_factor_for | disease | 0.85 |
| Alzheimer'S Disease | contributes_to | disease | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Sevoflurane | causes | drug | 0.95 |
| Neuroinflammation | causes | process | 0.92 |
| NLRP3 | associated_with | protein | 0.90 |
| Astrocytes | involved_in | cell_type | 0.90 |
| Oxidative Stress | causes | process | 0.90 |
| Itaconate | treats | compound | 0.88 |
| RU.521 | treats | drug | 0.85 |
| neuroinflammation | causes | process | 0.70 |
| SMAD7 | associated_with | protein | 0.70 |
| apoptosis | causes | process | 0.70 |
| ASTROCYTES | implicated_in | cell_type | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.589
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||