Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Survival: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| Serum NfL | associated_with | biomarker | 0.90 |
| Trastuzumab Deruxtecan | promotes | drug | 0.90 |
| Nfl | correlates_with | biomarker | 0.90 |
| ANXA1 | biomarker_for | protein | 0.88 |
| ANXA1 Expression | correlates_with | biomarker | 0.85 |
| T-cell receptor diversity | associates_with | process | 0.80 |
| Social Memory | contributes_to | process | 0.80 |
| DOT1L | downregulates | protein | 0.80 |
| PI3K/AKT/mTOR | regulates | entity | 0.80 |
| NF-κB | regulates | pathway | 0.80 |
| PI3K_AKT_MTOR | regulates | pathway | 0.72 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Heterogeneous astrocyte activation states differentially imp | 0.640 | Alzheimer's disease | SEA-AD Single-Cell Analysis: Cell-Type V |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 2 hypotheses Top: 0.778
translational neuroscience | 2026-04-04 | 7 hypotheses Top: 0.803
neurodegeneration | 2026-04-04 | 0 hypotheses
neurodegeneration | 2026-04-02 | 3 hypotheses Top: 0.652
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| iPSC-NPC effects on astrocytes in vitro ICH model | exploratory | intracerebral hemorrhage | 0.900 | 0.00 | in vitro ICH cell culture mode | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Brain atrophy patterns in anti-IgLON5 disease. [PMID:40650880] | Yogeshwar SM, Bartels F, Grüter T, Muñiz | Brain | 2026 | 0 |
| Potential diagnostic markers in Alzheimer's disease: current perspectives and fu [PMID:40911035] | Zheng M, Wang S, Jia J | Neurodegener Dis Manag | 2026 | 0 |
| Kidney Function, Alzheimer Disease Blood Biomarkers, and Dementia Risk in Commun [PMID:41337685] | Gasparini F, Valletta M, Vetrano DL, Ber | Neurology | 2026 | 0 |
| Impaired glymphatic function is associated with synaptic loss in cognitive impai [PMID:41454064] | Unknown | European journal of nuclear me | 2026 | 0 |
| The role of astrocytes in Alzheimer's disease: Pathophysiology, biomarkers, and [PMID:41527736] | Abedin MJ, Kastanenka KV | J Alzheimers Dis | 2026 | 0 |
| Biomarker-integrated prognostic stagings for Alzheimer's Disease. [PMID:41622252] | Shin D, Lee S, Kim JP, Jang H, Yun J et | Nat Commun | 2026 | 0 |
| Prognostic Value of Plasma NfL and GFAP for Conversion to Alzheimer's Disease an [PMID:41703957] | Özkurt Ç, Kelicen-Uğur P | Biomarkers | 2026 | 0 |
| Alzheimer's Disease as a Disorder of Neuroimmune Dysregulation. [PMID:41745721] | ["Aranda-Abreu GE", "Rojas-Dur\u00e1n F" | Neurol Int | 2026 | 0 |
| From scaffold to effector: reframing GFAP in neurodegeneration. [PMID:41775321] | Lu YH, Zhu XP, Li S, Zhang FN, Cai CB et | J Adv Res | 2026 | 0 |
| Translating neurofilament light chain testing into clinical practice: a multidis [PMID:41831326] | Furlan R, Di Sapio A, Ferraro D, Rossi E | Clin Chem Lab Med | 2026 | 0 |
| Role of astrocyte biomarker GFAP in early diagnosis and prognosis assessment of [PMID:41850459] | Li S, Wei S, Wang L, Yu T, Wang H et al. | Int J Biol Macromol | 2026 | 0 |
| Cerebral FURIN deficiency impairs astrocytic lipophagy through ITGAV maturation. [PMID:41376284] | Unknown | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.84 · 2026-04-16
closed · Rounds: 4 · Score: 0.84 · 2026-04-11
closed · Rounds: 4 · Score: 0.92 · 2026-04-04
closed · Rounds: 4 · Score: 0.73 · 2026-04-02