gene

DOT1L

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DOT1L: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

129Connections

0Hypotheses

0Analyses

50Outgoing

36Incoming

Summary

DOT1L - Histone H3K79 methyltransferase involved in epigenetic regulation and neurodegeneration

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🧬 Gene Info

Gene Symbol	DOT1L
Full Name	Histone H3K79 Methyltransferase
Aliases	Disruptor of Telomeric Silencing 1-like
Protein Type	Transferase
Function	encodes a protein of 1,670 amino acids with methyltransferase activity that is conserved from yeast to humans [2](https://pubmed.
Molecular Weight	190 kDa
Amino Acids	670 aa
Pathways	Calcium Signaling, Epigenetic, Hedgehog, Nf-Κb, Toll-Like Receptor
Ensembl ID	ENSG00000100811
GeneCards	DOT1L
Human Protein Atlas	DOT1L
H3K79me1	Associated with active gene expression, enriched in gene bodies
H3K79me2	Marks transcribed genes, particularly in promoter regions
H3K79me3	Correlates with highly expressed genes and DNA damage response
Associated Diseases	AD, Chemoresistance, Ms, OVARIAN CANCER, Ovarian Carcinoma
Interactions	PARP1, NLRP3, CANCER, Raf, Ras, App
KG Connections	129 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (12)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DOT1L["DOT1L"]
    DOT1L -->|"mediates"| PARP_Inhibitor_Resistance["PARP Inhibitor Resistance"]
    DOT1L -->|"involved_in"| Ovarian_Carcinoma["Ovarian Carcinoma"]
    DOT1L -->|"inhibits"| Cancer["Cancer"]
    DOT1L -->|"activates"| Carcinoma["Carcinoma"]
    DOT1L -->|"regulates"| Ms["Ms"]
    DOT1L -->|"regulates"| Als["Als"]
    DOT1L -->|"activates"| Inflammation["Inflammation"]
    DOT1L -->|"activates"| Fibrosis["Fibrosis"]
    PARP1["PARP1"] -->|"interacts"| DOT1L
    ABCB1["ABCB1"] -->|"contributes to"| DOT1L
    PLCG2["PLCG2"] -->|"contributes to"| DOT1L
    INFLAMMATION["INFLAMMATION"] -->|"activates"| DOT1L
    TFE3["TFE3"] -->|"regulates"| DOT1L
    PYROPTOSIS["PYROPTOSIS"] -->|"activates"| DOT1L
    GSDMD["GSDMD"] -->|"activates"| DOT1L
    IRF3["IRF3"] -->|"activates"| DOT1L
    STING["STING"] -->|"activates"| DOT1L

Outgoing (93)

Target	Relation	Type	Str
PARP Inhibitor Resistance	mediates	phenotype	0.90
PARP INHIBITOR RESISTANCE	mediates	entity	0.90
PARP Inhibitor Resistance	involved_in	phenotype	0.90
Parp Inhibitor Resistance	mediates	phenotype	0.90
Parpi Resistance	upregulates	phenotype	0.90
PARP inhibitor resistance	drives	phenotype	0.90
Ovarian Cancer	associated_with	disease	0.90
Ovarian Carcinoma	involved_in	disease	0.85
OVARIAN CANCER	associated_with	entity	0.85
PARP Inhibitor Resistance	contributes_to	phenotype	0.85
Ovarian Carcinoma	contributes_to	disease	0.85
Ovarian Carcinoma	associated_with	disease	0.85
Chemoresistance	contributes_to	phenotype	0.85
Ovarian Cancer	upregulates	disease	0.85
Chromatin Modification	involved_in	process	0.80
survival	downregulates	phenotype	0.80
PARP inhibitor	biomarker_for	drug	0.80
transcription	regulates	process	0.80
ABCB1	regulates	gene	0.80
Chemoresistance	associated_with	phenotype	0.80
Chemoresistance	involved_in	phenotype	0.75
OVARIAN CANCER	causes	disease	0.65
Cancer	inhibits	disease	0.65
Carcinoma	activates	disease	0.65
Ms	regulates	disease	0.65
Carcinoma	inhibits	disease	0.65
Als	regulates	disease	0.65
Inflammation	activates	disease	0.65
Fibrosis	activates	disease	0.65
Ms	activates	disease	0.65
Senescence	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Leukemia	therapeutic_target	disease	0.65
Covid	interacts_with	disease	0.65
PLCG2	contributes_to	gene	0.60
ABCB1	contributes_to	gene	0.60
PARP1	activates	gene	0.60
TFEB	regulates	gene	0.60
DNMT3A	regulates	gene	0.60
NLRP3	activates	gene	0.60
MTOR	associated_with	gene	0.60
PIEZO1	regulates	gene	0.60
CD14	regulates	gene	0.60
PARP1	inhibits	entity	0.60
PLCG2	regulates	entity	0.60
PARP1	contributes_to	entity	0.60
PARP1	implicated_in	gene	0.60
PLCG2	implicated_in	gene	0.60
PARP1	associated_with	gene	0.60
PLCG2	associated_with	gene	0.60

Incoming (36)

Source	Relation	Type	Str
PARP1	interacts_with	protein	0.90
PARP1	binds	protein	0.90
UBIQUITIN	binds_to	protein	0.85
BRCA mutation	associated_with	phenotype	0.75
ABCB1	contributes_to	gene	0.60
PARP1	activates	gene	0.60
PLCG2	contributes_to	gene	0.60
TFE3	regulates	gene	0.60
GSDMD	activates	gene	0.60
IRF3	activates	gene	0.60
STING	activates	gene	0.60
CD14	regulates	gene	0.60
PIEZO1	regulates	gene	0.60
OVERVIEW	implicated_in	gene	0.60
NAMPT	associated_with	gene	0.60
ABCB1	regulates	entity	0.60
BRCA	expressed_in	gene	0.60
ABCB1	implicated_in	gene	0.60
INFLAMMATION	activates	gene	0.60
PYROPTOSIS	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
TLR	regulates	gene	0.60
FBXW7	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
AND	regulates	gene	0.60
CANCER	inhibits	entity	0.60
CANCER	associated_with	entity	0.60
RNA	regulates	gene	0.60
AND	activates	gene	0.60
PARP1	inhibits	gene	0.50
PLCG2	regulates	gene	0.50
PLCG2	associated_with	gene	0.50
ABCB1	associated_with	gene	0.50
PARP1	associated_with	gene	0.50
ABCB1	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DOT1L

Understanding Entity Pages

Summary

Wiki Pages (12)

DOT1L Gene

Histone Modification Pathways in Neurodegeneration

Cellular Senescence in Brain Aging and Neurodegeneration

Chromatin Remodeling and Epigenetic Therapy Synthesis for Neurodegeneration

AHCYL1 Gene

DOT1L Protein

Histone Modifications

Alzheimer's Disease Histone Methylation and Epigenetic Writer Companies

PHF23 — PHD Finger Protein 23

Histone Methylation