gene 1,364 words KG: SMN1 2026-03-24
kind:genesection:genesstate:published
Contents

SMN1 - Survival Motor Neuron 1

🧬 Gene Info
Gene SymbolSMN1
Full NameSurvival Motor Neuron 1
Chromosome5q13.2
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary ExpressionMotor neurons, Spinal cord, Widespread
Molecular Weight38.0 kDa
Amino Acids294 aa
PathwaysDna Damage Response, autophagy pathway, oxidative stress response
UniProt IDQ16637
NCBI Gene ID6606
Ensembl IDENSG00000172062
OMIM600354
GeneCardsSMN1
Human Protein AtlasSMN1
Associated DiseasesALS, Amyotrophic Lateral Sclerosis, Ataxia, Dementia, Frontotemporal Dementia
Known Drugs/Compoundsrapamycin
InteractionsSMN2, ALS4, ATG7, GABARAP, HUNTINGTIN, DNMT1
KG Connections165 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (4)

Smartphone-Detected Motor Variability Correction
Score: 0.56
Axonal RNA Transport Reconstitution
Score: 0.45
R-Loop Resolution Enhancement Therapy
Score: 0.43
DNMT1-Targeting Antisense Oligonucleotide Reset
Score: 0.36

Related Analyses (3)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed

See Also (12)

Packard Center for ALS Research
institution · KG edge: associated_with
Dementia Australia
institution · KG edge: associated_with
DNMT1 Gene
gene · KG edge: activates
BECN1 Gene
gene · KG edge: activates
ATG7 Gene
gene · KG edge: activates

Knowledge Graph (12 edges)

SMN1 associated_with DNMT1
SMN1 associated_with ULK1
SMN1 associated_with P62
SMN1 associated_with TFEB
SMN1 associated_with ATG7
SMN1 associated_with ALS4
SMN1 associated_with HTT
SMN1 associated_with BECN1
SMN1 associated_with SETX
SMN1 associated_with LC3