protein 1,346 words KG: SMN 2026-03-23
kind:proteinsection:proteinsstate:published
Contents

Survival Motor Neuron (SMN)

🔬 Protein Info
Gene SymbolSMN
Chromosome5q13.2.
FunctionSMN is essential for cellular viability, and complete absence is embryonically lethal.
Primary ExpressionSpinal Cord, Ca1, Cerebellum
Molecular Weight38 kDa
Amino Acids294 aa
Exons2
PathwaysTdp-43, Apoptosis, Er Stress, Cell Cycle, CRISPR-Cas
GeneCardsSMN
Human Protein AtlasSMN
Gene [^6] [SMN1](/entities/smn1) [^7] [^8] [^9] UniProt [^10] Q16637 [^11] [^12] [@external] PDB [^14] 4A4G (Tudor domain), 4GLI (YG-dimer) [^15] [^16] [^17] Mol. Weight [@ref] ~38 kDa (294 amino acids) [@smn] [@refa] [@omim] Localization [@ncbi] Nucleus (gems/Cajal bodies), cytoplasm FamilyTudor domain protein family
Associated DiseasesALS, Amyotrophic Lateral Sclerosis, Dementia, Frontotemporal Dementia, Spinal Muscular Atrophy
InteractionsSTMN2, TDP-43, CHMP7, Rb, ALS, NEURON
KG Connections121 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (2)

Smartphone-Detected Motor Variability Correction
Score: 0.56
Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m
Score: 0.35

Related Analyses (4)

Digital biomarkers and AI-driven early detection of neurodeg
neurodegeneration · archived
Mitochondrial transfer between astrocytes and neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived
Metabolic reprogramming in neurodegenerative disease
neurodegeneration · completed

See Also (13)

CCNF Protein (Cyclin F)
protein · KG edge: encodes
Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: encodes
Packard Center for ALS Research
institution · KG edge: activates
Dementia Australia
institution · KG edge: associated_with
CNTN4 — Contactin 4
gene · KG edge: encodes

Knowledge Graph (12 edges)

SMN associated_with SMN2
SMN associated_with TIA1
SMN expressed_in CNTN4
SMN interacts_with STMN2
SMN interacts_with TDP-43
SMN interacts_with CHMP7
SMN causes SMN1
SMN expressed_in ALDH1A2
SMN encodes CCNF
SMN encodes TBC1D24