pathway

PI3K/AKT/mTOR

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K/AKT/mTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

388Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	PI3K/AKT/mTOR
Key Genes/Proteins	SYK
Related Diseases	multiple myeloma, Hormone Receptor-Positive Breast Cancer, Breast Cancer, Triple-Negative Breast Cancer, ER+ Breast Cancer

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PI3K_AKT_mTOR["PI3K/AKT/mTOR"] -->|"regulates"| Cell_Proliferation["Cell Proliferation"]
    style Cell_Proliferation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    PI3K_AKT_mTOR["PI3K/AKT/mTOR"] -->|"regulates"| Cell_Survival["Cell Survival"]
    style Cell_Survival fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    PI3K_AKT_mTOR["PI3K/AKT/mTOR"] -->|"activates"| multiple_myeloma["multiple myeloma"]
    style multiple_myeloma fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    PI3K_AKT_mTOR["PI3K/AKT/mTOR"] -->|"involved in"| Hormone_Receptor_Positive_Brea["Hormone Receptor-Positive Breast Cancer"]
    style Hormone_Receptor_Positive_Brea fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    PI3K_AKT_mTOR["PI3K/AKT/mTOR"] -->|"involved in"| Breast_Cancer["Breast Cancer"]
    style Breast_Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    PI3K_AKT_mTOR["PI3K/AKT/mTOR"] -->|"activates"| Triple_Negative_Breast_Cancer["Triple-Negative Breast Cancer"]
    style Triple_Negative_Breast_Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    PI3K_AKT_mTOR["PI3K/AKT/mTOR"] -->|"causes"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Capivasertib["Capivasertib"] -.->|"inhibits"| PI3K_AKT_mTOR["PI3K/AKT/mTOR"]
    style Capivasertib fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Alpelisib["Alpelisib"] -.->|"inhibits"| PI3K_AKT_mTOR["PI3K/AKT/mTOR"]
    style Alpelisib fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    SYK["SYK"] -->|"regulates"| PI3K_AKT_mTOR["PI3K/AKT/mTOR"]
    style SYK fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    MTOR["MTOR"] -->|"component of"| PI3K_AKT_mTOR["PI3K/AKT/mTOR"]
    style MTOR fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    BBR["BBR"] -.->|"inhibits"| PI3K_AKT_mTOR["PI3K/AKT/mTOR"]
    style BBR fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    style PI3K_AKT_mTOR fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (193)

Target	Relation	Type	Str
Cell Proliferation	regulates	process	0.95
Cell Survival	regulates	process	0.95
multiple myeloma	activates	disease	0.95
Hormone Receptor-Positive Breast Cancer	involved_in	disease	0.95
Breast Cancer	involved_in	disease	0.95
Triple-Negative Breast Cancer	activates	disease	0.95
ER+ Breast Cancer	involved_in	disease	0.95
Gastric Cancer	involved_in	disease	0.95
Cancer	involved_in	disease	0.95
multiple myeloma	therapeutic_target	disease	0.92
Cancer	causes	disease	0.90
Pluripotency	regulates	phenotype	0.90
Cell Fate Determination	regulates	process	0.90
Cellular Differentiation	involved_in	process	0.90
Pluripotent Stem Cells	regulates	cell_type	0.90
triple-negative breast cancer	associated_with	disease	0.90
triple-negative breast cancer	promotes	disease	0.90
cell proliferation	regulates	process	0.90
myeloma cell proliferation	promotes	process	0.90
myeloma cell survival	promotes	process	0.90
triple-negative breast cancer	therapeutic_target	disease	0.90
Cell Growth	regulates	biological_process	0.90
Cancer	associated_with	disease	0.90
Gastric Cancer	associated_with	disease	0.90
Endocrine Therapy Resistance	causes	phenotype	0.90
CDK4/6 Inhibitor Resistance	causes	phenotype	0.90
Tumor Growth	regulates	process	0.90
Breast Cancer Growth	contributes_to	phenotype	0.90
Cell Proliferation	contributes_to	process	0.90
Triple-negative breast cancer	implicated_in	disease	0.90
ER+ breast cancer	implicated_in	disease	0.90
Breast cancer	implicated_in	disease	0.90
multiple myeloma	implicated_in	disease	0.90
Drug Resistance	contributes_to	phenotype	0.90
lipid metabolism	regulates	process	0.90
Treatment Resistance	causes	phenotype	0.88
Development	involved_in	process	0.85
Tumorigenesis	associated_with	disease	0.85
angiogenesis	promotes	process	0.85
drug resistance	promotes	phenotype	0.85
Endometriosis-Associated Ovarian Cancer	involved_in	disease	0.85
Angiogenesis	contributes_to	process	0.85
BAX	inhibits	protein	0.85
GFAP	upstream_of	protein	0.85
Hepatocellular carcinoma	drives	disease	0.85
ovarian follicle development	activates	process	0.85
Cell growth	regulates	biological_process	0.80
Survival	regulates	biological_process	0.80
Metabolism	regulates	biological_process	0.80
apoptosis	regulates	phenotype	0.80

Incoming (195)

Source	Relation	Type	Str
Capivasertib	inhibits	drug	0.95
Alpelisib	inhibits	drug	0.95
SYK	regulates	protein	0.95
MTOR	component_of	protein	0.90
BBR	inhibits	drug	0.90
FBXO32	activates	protein	0.90
B.glomerulata	activates	drug	0.90
DNA Methylation	regulates	mechanism	0.90
Non-coding RNAs	regulates	biomarker	0.90
bone marrow microenvironment	activates	cell_type	0.88
kinase inhibitors	inhibits	drug	0.88
IRGM1	upstream_of	protein	0.85
AKT	upstream_of	protein	0.85
Chrysotoxine	inhibits	compound	0.85
PIK3CA	activates	gene	0.85
PTEN	inhibits	gene	0.85
Kinase Inhibitors	inhibits	drug	0.85
H. pylori	regulates	biomarker	0.85
Epstein-Barr Virus	regulates	biomarker	0.85
STK11	regulates	gene	0.85
METFORMIN	inhibits	drug	0.80
AKT	activates	gene	0.80
Gnetupendin A	activates	compound	0.80
Ginsenoside RG3	inhibits	compound	0.80
Cantharidin	inhibits	drug	0.80
curcumin	regulates	drug	0.70
Gomisin N	activates	chemical	0.70
AKT	regulates	gene	0.70
Pi3K	activates	pathway	0.50
PTEN	activates	gene	0.50
mTOR	activates	entity	0.50
cancer	activates	disease	0.50
TUMOR	activates	disease	0.50
GLYCOLYSIS	activates	pathway	0.50
Pi3K/Akt	activates	pathway	0.50
STROKE	activates	gene	0.50
Autophagy	activates	process	0.50
ISCHEMIC	activates	concept	0.50
GLIOBLASTOMA	activates	gene	0.50
Pi3K	associated_with	pathway	0.50
mTOR	associated_with	entity	0.50
TUMOR	associated_with	disease	0.50
Pi3K/Akt	associated_with	pathway	0.50
Pi3K	regulates	pathway	0.50
mTOR	regulates	entity	0.50
Pi3K/Akt	regulates	pathway	0.50
cancer	associated_with	disease	0.50
Pi3K	causes	pathway	0.50
mTOR	causes	entity	0.50
TUMOR	causes	disease	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PI3K/AKT/mTOR

Understanding Entity Pages

Wiki Pages (20)

nf1-protein

IGF-1 Signaling Pathway in Neurodegeneration

Cellular Senescence in Neurodegeneration

TREM2→Microglial Dysfunction→Alzheimer's Disease Causal Chain

EPHA7 Gene

Remyelination in Neurodegeneration

FA2H Gene

Cellular Senescence in Neurodegeneration

EPHA8 Gene

Apoptosis in Neurodegeneration

CD200R1 Gene

Senolytic Therapies for CBS and [PSP](/diseases/progressive-supranuclear-palsy)

PITX3 Protein

Activity-Dependent Synaptic Plasticity in Neurodegeneration

RRAS2 — Related RAS Virus (R-Ras) Family Member 2

YAP/TAZ Signaling Pathway in Neurodegeneration

PI3K/Akt Activator Clinical Trials for Parkinson's Disease

SPI1 Gene - PU.1