Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TDP-43 aggregates: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| Cytoplasmic Inclusions | associated_with | phenotype | 0.92 |
| Loss Of Function | causes | phenotype | 0.92 |
| TDP-43 | associated_with | protein | 0.90 |
| TARDBP | associated_with | protein | 0.90 |
| Prion-Like Cascade | involved_in | process | 0.90 |
| Cell-To-Cell Spreading | mediates | process | 0.88 |
| Cryptic Splicing | mediates | process | 0.88 |
| Amyotrophic Lateral Sclerosis | biomarker_for | disease | 0.85 |
| ALS | associated_with | disease | 0.70 |
| FTD | associated_with | disease | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.760
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity