Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about AUTOPHAGOSOME-LYSOSOME FUSION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | AUTOPHAGOSOME-LYSOSOME FUSION |
Knowledge base pages for this entity
graph TD
AUTOPHAGOSOME_LYSOSOME_FUSION["AUTOPHAGOSOME-LYSOSOME FUSION"]
AUTOPHAGOSOME_LYSOSOME_FUSION -->|"component_of"| Macroautophagy["Macroautophagy"]
AUTOPHAGOSOME_LYSOSOME_FUSION -->|"regulates"| SQSTM1["SQSTM1"]
AUTOPHAGOSOME_LYSOSOME_FUSION -->|"involved_in"| Autophagic_Clearance["Autophagic Clearance"]
TGM2["TGM2"] -->|"regulates"| AUTOPHAGOSOME_LYSOSOME_FUSION
STX17["STX17"] -->|"mediates"| AUTOPHAGOSOME_LYSOSOME_FUSION
SNAP29["SNAP29"] -->|"mediates"| AUTOPHAGOSOME_LYSOSOME_FUSION
VAMP8["VAMP8"] -->|"mediates"| AUTOPHAGOSOME_LYSOSOME_FUSION
VAMP7["VAMP7"] -->|"mediates"| AUTOPHAGOSOME_LYSOSOME_FUSION
SNARE_PROTEINS["SNARE PROTEINS"] -->|"regulates"| AUTOPHAGOSOME_LYSOSOME_FUSION
RUBCN["RUBCN"] -->|"inhibits"| AUTOPHAGOSOME_LYSOSOME_FUSION
Aloperine["Aloperine"] -->|"inhibits"| AUTOPHAGOSOME_LYSOSOME_FUSION| Target | Relation | Type | Str |
|---|---|---|---|
| Macroautophagy | component_of | process | 0.95 |
| macroautophagy | mediates | process | 0.90 |
| SQSTM1 | regulates | protein | 0.85 |
| Neuronal Triage | involved_in | mechanism | 0.85 |
| Autophagic Clearance | involved_in | process | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TGM2 | regulates | protein | 0.95 |
| STX17 | mediates | protein | 0.95 |
| SNAP29 | mediates | protein | 0.95 |
| VAMP8 | mediates | protein | 0.95 |
| VAMP7 | mediates | protein | 0.95 |
| SNARE PROTEINS | regulates | protein | 0.95 |
| RUBCN | inhibits | protein | 0.95 |
| Aloperine | inhibits | compound | 0.95 |
| SNARE PROTEINS | mediates | protein | 0.95 |
| MCOLN1 | associated_with | gene | 0.95 |
| ISG15 | inhibits | gene | 0.95 |
| TRIM22 | associated_with | protein | 0.95 |
| LAMP2B | involved_in | protein | 0.95 |
| GABARAPL2 | regulates | protein | 0.92 |
| ATG2A | participates_in | protein | 0.90 |
| EPG5 | mediates | protein | 0.90 |
| YKT6 | involved_in | protein | 0.90 |
| MCOLN1 | inhibits | protein | 0.90 |
| RAB7A | promotes | protein | 0.90 |
| RAB7A | activates | protein | 0.90 |
| SNAP29 | involved_in | protein | 0.90 |
| VAMP8 | involved_in | protein | 0.90 |
| VAMP7 | involved_in | protein | 0.90 |
| Tetrathiomolybdate | inhibits | drug | 0.90 |
| RAB7A | promotes | protein | 0.90 |
| HDAC6 | regulates | protein | 0.90 |
| YKT6 | mediates | protein | 0.90 |
| HDAC6 | promotes | gene | 0.90 |
| AMPK | regulates | protein | 0.90 |
| RAB7A Ubiquitylation | inhibits | mechanism | 0.88 |
| TRIM22 Variant | inhibits | biomarker | 0.87 |
| RAB7A | regulates | protein | 0.85 |
| VPS4A | regulates | protein | 0.85 |
| ESCRT-III | regulates | protein | 0.85 |
| metformin | associated_with | drug | 0.85 |
| STX17 | involved_in | protein | 0.80 |
| RAB7A ubiquitylation | impairs | process | 0.80 |
| LRRK2 | regulates | protein | 0.80 |
| STX17 | regulates | protein | 0.70 |
| SNARE proteins | involved_in | protein | 0.70 |
| TRIM22 | activates | protein | 0.70 |
| LAMP2B | regulates | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso | 0.542 | neurodegeneration | What molecular mechanisms link elevated |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||