Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CRYPTIC SPLICING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CRYPTIC SPLICING |
Knowledge base pages for this entity
graph TD
CRYPTIC_SPLICING["CRYPTIC SPLICING"]
CRYPTIC_SPLICING -->|"contributes to"| Neurodegeneration["Neurodegeneration"]
TDP_LOF["TDP-LOF"] -->|"causes"| CRYPTIC_SPLICING
TARDBP["TARDBP"] -->|"mediates"| CRYPTIC_SPLICING
TDP43["TDP43"] -->|"inhibits"| CRYPTIC_SPLICING
Antisense_Oligonucleotides["Antisense Oligonucleotides"] -->|"inhibits"| CRYPTIC_SPLICING
TDP_43["TDP-43"] -->|"causes"| CRYPTIC_SPLICING
TDP_REG["TDP-REG"] -->|"targets"| CRYPTIC_SPLICING| Target | Relation | Type | Str |
|---|---|---|---|
| PKN1-N207 | associated_with | protein | 0.90 |
| Amyotrophic Lateral Sclerosis | biomarker_for | disease | 0.90 |
| Frontotemporal Dementia | biomarker_for | disease | 0.90 |
| Neurodegeneration | contributes_to | phenotype | 0.85 |
| ATG4B | associated_with | gene | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TDP-LOF | causes | mechanism | 0.95 |
| TDP-43 | regulates | protein | 0.95 |
| TARDBP | mediates | protein | 0.92 |
| TDP43 | inhibits | protein | 0.90 |
| TARDBP | inhibits | protein | 0.90 |
| Antisense Oligonucleotides | inhibits | drug | 0.90 |
| TDP-43 | causes | protein | 0.90 |
| TARDBP | regulates | protein | 0.90 |
| TDP-REG | targets | mechanism | 0.90 |
| TDP-43 | inhibits | protein | 0.88 |
| TDP-43 Aggregates | mediates | protein | 0.88 |
| TDP-43/Raver1 Fusion Protein | treats | protein | 0.88 |
| TDP-43 | mediates | protein | 0.88 |
| C9ORF72 | contributes_to | gene | 0.88 |
| TDP-43 Cytoplasmic Aggregates | mediates | compound | 0.85 |
| UNC13A | involved_in | gene | 0.85 |
| Splicenouveau Algorithm | associated_with | mechanism | 0.85 |
| RNA-Binding Proteins | regulates | protein | 0.85 |
| ATG4B | involved_in | protein | 0.80 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||