mechanism

TDP-43 Proteinopathy

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TDP-43 Proteinopathy: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

22Connections

2Hypotheses

3Analyses

6Outgoing

16Incoming

0Experiments

5Debates

Summary

Tdp 43 Proteinopathy is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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⚙ Mechanism Info

Name	TDP-43 Proteinopathy
Key Genes/Proteins	MAPK14, TDP-43
Related Diseases	Amyotrophic Lateral Sclerosis

Wiki Pages (9)

Knowledge base pages for this entity

TDP-43 Proteinopathy

mechanism · 4112 words

Validated Hypothesis: Microglial AIM2 Inflammasome as the Primary Driver of TDP-43 Proteinopathy Neuroinflammation in ALS/FTD

hypothesis · 5607 words

TDP-43 Proteinopathy in Amyotrophic Lateral Sclerosis

mechanism · 3471 words

TDP-43 Proteinopathy in ALS

mechanism · 1751 words

Cryptic Exon Splicing in TDP-43 Proteinopathy

mechanism · 1514 words

TDP-43 Proteinopathy Neurons

cell · 1252 words

Pathway Diagram

graph TD
    TDP_43_Proteinopathy["TDP-43 Proteinopathy"]
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    TDP_43_Proteinopathy -->|"involved in"| Amyotrophic_Lateral_Sclerosis
    Als{"Als"}
    TDP_43_Proteinopathy -->|"involved in"| Als
    Ftld{"Ftld"}
    TDP_43_Proteinopathy -->|"involved in"| Ftld
    MAPK14["MAPK14"]
    TDP_43_Proteinopathy -->|"contributes to"| MAPK14
    TDP_43["TDP-43"]
    TDP_43_Proteinopathy -->|"involved in"| TDP_43
    Neurodegenerative_Diseases{"Neurodegenerative Diseases"}
    TDP_43_Proteinopathy -->|"implicated in"| Neurodegenerative_Diseases
    Proteinopathy(["Proteinopathy"])
    TDP_43_Proteinopathy -->|"regulates"| Proteinopathy
    style TDP_43_Proteinopathy fill:#2a1a3a,stroke:#b39ddb,stroke-width:3px,color:#fff
    style Neurodegenerative_Diseases fill:#4a1a1a,stroke:#ef5350,stroke-width:1px,color:#ef5350
    style Proteinopathy fill:#2a2a1a,stroke:#ffd54f,stroke-width:1px,color:#ffd54f

Outgoing (6)

Target	Relation	Type	Str
STMN2 splicing dysregulation	causes	mechanism	0.90
ALS-FTD-AD spectrum	biomarker_for	disease	0.90
axonal degeneration	causes	phenotype	0.90
Frontotemporal Lobar Degeneration	involved_in	disease	0.90
Amyotrophic Lateral Sclerosis	biomarker_for	disease	0.90
nuclear TDP-43 depletion	causes	mechanism	0.70

Incoming (16)

Source	Relation	Type	Str
MAPK14	contributes_to	gene	0.95
TARDBP	involved_in	protein	0.95
C9ORF72	causes	gene	0.90
stress granules	mediates	organelle	0.90
TDP-43	biomarker_for	protein	0.90
36922834	spans a spectrum of	paper	0.90
36922834	leads to	paper	0.90
Progranulin-Deficient Astrocytes	promotes	cell_type	0.85
C9orf72 repeat expansion	causes	gene	0.80
SOD1	associated_with	gene	0.80
PRMT1-mediated arginine methylation	opposes	process	0.80
STMN2 splicing dysregulation	biomarker_for	mechanism	0.70
ATXN2	associated_with	gene	0.70
C9orf72 repeat-associated transcripts	contributes_to	pathway	0.60
24113586	is associated with	paper	0.60
33967699	may impact	paper	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43	0.824	neurodegeneration	What are the mechanisms by which gut mic
TDP-43 Proteinopathy as a Cross-Disease Pathological Substra	0.760	neurodegeneration	Cross-disease neurodegeneration mechanis

Mentioning Analyses (3)

Scientific analyses that reference this entity

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

neurodegeneration | 2026-04-28 | 7 hypotheses Top: 0.662

RNA binding protein dysregulation across ALS FTD AD

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.664

Gap 006 analysis (archived stub)

neurodegeneration | 2026-04-02 | 7 hypotheses Top: 0.760

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (5)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Small molecule-driven NLRP3 inflammation inhibition via interplay between ubiqui [PMID:30966861]	["Han X", "Sun S", "Sun Y", "Song Q", "Z	Autophagy	2020	1
Inhibition of autophagy in microglia and macrophages exacerbates innate immune r [PMID:36652438]	Hegdekar N, Sarkar C, Bustos S, Ritzel R	Autophagy	2023	0
Inflammasome assembly in neurodegenerative diseases. [PMID:37633753]	Singh J, Habean ML, Panicker N	Trends in neurosciences	2023	0
NLRP3/caspase-1/GSDMD-mediated pyroptosis exerts a crucial role in astrocyte pat [PMID:34877938]	Li S, Sun Y, Song M, Song Y, Fang Y, Zha	JCI insight	2021	0
Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodeg [PMID:30381407]	Gordon R, Albornoz EA, Christie DC, Lang	Science translational medicine	2018	0

Debates (5)

Multi-agent debates referencing this entity

Structured research brief: Stathmin-2 Splice Switching to Prevent Axonal Degener

archived · Rounds: 2 · Score: 0.73 · 2026-04-28

Methodology challenge: dataset 'Allen Brain SEA-AD Single Cell Dataset' — evalua

closed · Rounds: 4 · Score: 0.76 · 2026-04-28

Hypothesis debate: Stathmin-2 Splice Switching to Prevent Axonal Degeneration Ac

closed · Rounds: 4 · Score: 0.49 · 2026-04-27

Analysis for knowledge gap 006 in the neurodegeneration domain.

closed · Rounds: 4 · Score: 0.79 · 2026-04-22

RNA binding protein dysregulation across ALS FTD AD

closed · Rounds: 4 · Score: 0.50 · 2026-04-13

Related Research

Hypotheses and analyses mentioning TDP-43 Proteinopathy in their description or question text

No additional research found