protein

TET1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TET1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

Summary

Tet1 Protein is involved in cellular processes relevant to neurodegeneration. For detailed information, refer to the References section.

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🔬 Protein Info

Gene Symbol	TET1
Full Name	Tet Methylcytosine Dioxygenase 1
Chromosome	10q21.3
Protein Type	Gene
Function	Unlike passive demethylation (which occurs during DNA replication without maintenance of methylation marks), TET1-mediated demethylation is an active, enzyme-driven process
Primary Expression	embryonic stem cells and neural progenitor cells, and is essential for pluripotency and neurogenesis
Subcellular Localization	** Nucleus
Amino Acids	2136 aa
Pathways	epigenetic regulation, neurotrophin signaling, unfolded protein response
UniProt ID	Q8NFU7
NCBI Gene ID	80312
Ensembl ID	ENSG00000138336
OMIM	607042
GeneCards	TET1
Human Protein Atlas	TET1
Associated Diseases	Rett Syndrome, Alzheimer Disease, Parkinson Disease, Intellectual Disability
Known Drugs/Compounds	Arsenic
Interactions	TET2, TET3, INFLAMMATION, DNA, GENES, BDNF
KG Connections	32 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TET1PROTEIN — AlphaFold SEARCH Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Tet Methylcytosine Dioxygenase 1 Protein

protein · 502 words

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Pathway Diagram

graph TD
    TET1PROTEIN["TET1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    TET1PROTEIN -->|"implicated_in"| neurodegeneration
    style TET1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found