THAP1

Understanding Entity Pages

This page aggregates everything SciDEX knows about THAP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

THAP1 encodes a zinc finger transcription factor (THAP1) involved in cell cycle control, apoptosis, and neuronal function. THAP1 mutations cause Dystonia 6 (DYT6), a form of autosomal dominant dystonia with prominent craniocervical involvement.

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flowchart TD
    N0["THAP1"]
    N1["Als"]
    N0 -->|"associated with"| N1
    N2["ANO3"]
    N0 -->|"associated with"| N2
    N3["ANXIETY"]
    N0 -->|"contributes to"| N3
    N4["GNAL"]
    N0 -->|"associated with"| N4
    N5["DEPRESSION"]
    N0 -->|"contributes to"| N5
    N6["TOR1A"]
    N0 -->|"associated with"| N6
    N7["Actin"]
    N0 -->|"contributes to"| N7
    N8["GCH1"]
    N8 -->|"associated with"| N0
    N9["neurodegeneration"]
    N0 -->|"implicated in"| N9

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 gene
    class N7 protein
    class N8 gene