GNAL

Understanding Entity Pages

This page aggregates everything SciDEX knows about GNAL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

GNAL encodes the Gαolf protein, which couples dopamine D1 and adenosine A2A receptors to cAMP signaling in the striatum, with roles in dystonia and Parkinson's disease.

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graph TD
    GNAL["<b>GNAL</b>"]
    VAMP7["VAMP7"]
    GNAL -->|"expressed in"| VAMP7
    MMP9["MMP9"]
    GNAL -->|"expressed in"| MMP9
    PI3K["PI3K"]
    GNAL -->|"inhibits"| PI3K
    AKT["AKT"]
    GNAL -->|"associated with"| AKT
    AKT1["AKT1"]
    GNAL -->|"associated with"| AKT1
    NF__B["NF-KappaB"]
    GNAL -->|"inhibits"| NF__B
    MCC["MCC"]
    GNAL -->|"expressed in"| MCC
    AUTOPHAGY["AUTOPHAGY"]
    GNAL -->|"expressed in"| AUTOPHAGY
    CXCR4["CXCR4"]
    GNAL -->|"expressed in"| CXCR4
    ALDH1A3["ALDH1A3"]
    GNAL -->|"associated with"| ALDH1A3
    Autophagy(["Autophagy"])
    GNAL -->|"expressed in"| Autophagy
    Glycolysis(["Glycolysis"])
    GNAL -->|"expressed in"| Glycolysis
    style GNAL fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0