Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TNBC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Associated Genes | PRMT1, PHGDH, FASN |
| Therapeutic Agents | LUTEOLIN, Salidroside |
| KG Connections | 15 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
TNBC["TNBC"] -->|"causes"| Brain_Metastasis["Brain Metastasis"]
style Brain_Metastasis fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
TNBC["TNBC"] -->|"associated"| Perivascular_Sheath_Formation["Perivascular Sheath Formation"]
style Perivascular_Sheath_Formation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
TNBC["TNBC"] -->|"interacts"| Astrocyte["Astrocyte"]
style Astrocyte fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
TNBC["TNBC"] -->|"interacts"| Microglia["Microglia"]
style Microglia fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
TNBC["TNBC"] -->|"interacts"| ASTROCYTES["ASTROCYTES"]
style ASTROCYTES fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Salidroside["Salidroside"] -->|"treats"| TNBC["TNBC"]
style Salidroside fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
Ferroptosis_Related_Genes["Ferroptosis-Related Genes"] -->|"biomarker for"| TNBC["TNBC"]
style Ferroptosis_Related_Genes fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
WDR41["WDR41"] -->|"regulates"| TNBC["TNBC"]
style WDR41 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
LUTEOLIN["LUTEOLIN"] -->|"treats"| TNBC["TNBC"]
style LUTEOLIN fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
MMP9["MMP9"] -->|"activates"| TNBC["TNBC"]
style MMP9 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
style TNBC fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Brain Metastasis | causes | disease | 0.95 |
| Brain Metastasis | associated_with | disease | 0.95 |
| Perivascular Sheath Formation | associated_with | phenotype | 0.90 |
| Perivascular Sheath Formation | promotes | phenotype | 0.90 |
| Astrocyte | interacts_with | cell_type | 0.85 |
| Microglia | interacts_with | cell_type | 0.85 |
| ASTROCYTES | interacts_with | cell_type | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Salidroside | treats | compound | 0.95 |
| Ferroptosis-Related Genes | biomarker_for | biomarker | 0.80 |
| WDR41 | downregulates | protein | 0.70 |
| LUTEOLIN | treats | drug | 0.64 |
| MMP9 | activates | protein | 0.64 |
| PRMT1 | implicated_in | gene | 0.50 |
| PHGDH | implicated_in | gene | 0.50 |
| FASN | implicated_in | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||