concept

PHGDH

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PHGDH: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

188Connections

0Hypotheses

0Analyses

50Outgoing

41Incoming

Summary

PHGDH is a concept in neurodegeneration research. Key relationships include: activates, therapeutic target, regulates. Associated with AD, AMI, ARM. Connected to 135 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	PHGDH
Key Genes/Proteins	PRMT1, IDH1
Related Diseases	Liver Invasion, Cancer, Tumor, Als
Related Pathways	Prmt1-Dependent Methylation Of Phgdh At R54 Or R20, De Novo Fatty Acid Synthesis, Glycolysis

Wiki Pages (4)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PHGDH["PHGDH"]
    PHGDH -->|"causes"| Alzheimer_s_disease["Alzheimer's disease"]
    PHGDH -->|"regulates"| Aging["Aging"]
    PHGDH -->|"regulates"| Ms["Ms"]
    PHGDH -->|"activates"| Cancer["Cancer"]
    PHGDH -->|"activates"| Tumor["Tumor"]
    PHGDH -->|"activates"| Als["Als"]
    PHGDH -->|"regulates"| Alzheimer["Alzheimer"]
    IDH1["IDH1"] -->|"upregulates"| PHGDH
    DDB1["DDB1"] -->|"binds"| PHGDH
    FASN["FASN"] -->|"activates"| PHGDH
    PRMT1["PRMT1"] -->|"activates"| PHGDH
    ERK["ERK"] -->|"activates"| PHGDH
    GAIN["GAIN"] -->|"activates"| PHGDH
    AKT["AKT"] -->|"target for"| PHGDH
    ELF3["ELF3"] -->|"activates"| PHGDH
    PI3K["PI3K"] -->|"activates"| PHGDH
    TP53["TP53"] -->|"activates"| PHGDH

Outgoing (147)

Target	Relation	Type	Str
methyl donor production	regulates	process	0.88
Liver Invasion	contributes_to	phenotype	0.85
De Novo Fatty Acid Synthesis	involved_in	pathway	0.85
Cancer	associated_with	disease	0.75
Cancer	activates	disease	0.75
Tumor	activates	disease	0.75
Als	activates	disease	0.75
Glycolysis	associated_with	pathway	0.70
CANCER	activates	gene	0.70
Aging	regulates	disease	0.65
Ms	regulates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ms	activates	disease	0.65
Alzheimer	regulates	disease	0.65
Als	inhibits	disease	0.65
Ms	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Heart Failure	therapeutic_target	disease	0.65
Cancer	expressed_in	disease	0.65
Cancer	causes	disease	0.65
Tumor	associated_with	disease	0.65
Colorectal Cancer	activates	disease	0.65
Aging	methylates	disease	0.65
liver_invasion	activates	phenotype	0.64
ACAT1	associated_with	gene	0.60
PI3K	activates	gene	0.60
ERBB2	activates	gene	0.60
AKT	activates	gene	0.60
ERBB3	activates	gene	0.60
TP53	activates	gene	0.60
MEIS1	activates	gene	0.60
ELF3	activates	gene	0.60
Akt	activates	pathway	0.60
Pi3K	activates	pathway	0.60
Mapk	activates	pathway	0.60
PRMT1	activates	gene	0.60
Akt	therapeutic_target	pathway	0.60
Mapk	therapeutic_target	pathway	0.60
Pi3K	therapeutic_target	pathway	0.60
MTOR	activates	gene	0.60
ATG12	regulates	gene	0.60
EIF2A	activates	gene	0.60
ASNS	regulates	gene	0.60
CAT	regulates	gene	0.60
ATG3	regulates	gene	0.60
ATG10	regulates	gene	0.60
AUTOPHAGY	regulates	gene	0.60
MTORC1	activates	gene	0.60

Incoming (41)

Source	Relation	Type	Str
PRMT1	phosphorylates	protein	0.95
PRMT1	associated_with	gene	0.95
PRMT1	modulates	gene	0.90
Prmt1-Dependent Methylation Of Phgdh At R54 Or R20	activates	mechanism	0.90
Prmt1-Dependent Methylation	activates	process	0.90
IDH1	upregulates	gene	0.80
DDB1	binds	entity	0.80
FASN	activates	gene	0.60
PRMT1	activates	gene	0.60
ERK	activates	gene	0.60
GAIN	activates	gene	0.60
ACAT1	associated_with	gene	0.60
AKT	therapeutic_target	gene	0.60
ELF3	activates	gene	0.60
PI3K	activates	gene	0.60
TP53	activates	gene	0.60
ERBB3	activates	gene	0.60
AKT	activates	gene	0.60
ERBB2	activates	gene	0.60
RAS	activates	gene	0.60
ACAT1	causes	gene	0.60
MEIS1	activates	gene	0.60
CANCER	activates	gene	0.60
HK2	associated_with	gene	0.60
TP53	associated_with	gene	0.60
MTORC1	associated_with	gene	0.60
CANCER	associated_with	gene	0.60
GENES	associated_with	gene	0.60
PFKFB3	activates	gene	0.60
PKM2	methylates	gene	0.60
PRMT1	methylates	gene	0.60
PFKFB3	methylates	gene	0.60
GSH	activates	gene	0.60
NADPH	activates	gene	0.60
HMGB1	activates	gene	0.60
cancer	causes	disease	0.50
PKM2	associated_with	protein	0.50
PFKFB3	associated_with	protein	0.50
PKM2	regulates	protein	0.50
PFKFB3	regulates	protein	0.50
PKM2	activates	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found