WDR41

Understanding Entity Pages

This page aggregates everything SciDEX knows about WDR41: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

WDR41 gene encoding WD repeat domain 41 - component of C9orf72-SMCR8-WDR41 complex in autophagy-lysosome pathway

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graph TD
    WDR41["<b>WDR41</b>"]
    SMCR8["SMCR8"]
    WDR41 -->|"interacts with"| SMCR8
    TNBC{"TNBC"}
    WDR41 -->|"downregulates"| TNBC
    cell_viability["cell_viability"]
    WDR41 -->|"inhibits"| cell_viability
    cell_migration["cell_migration"]
    WDR41 -->|"inhibits"| cell_migration
    Als{"Als"}
    WDR41 -->|"associated with"| Als
    Ms{"Ms"}
    WDR41 -->|"interacts with"| Ms
    Inflammation{"Inflammation"}
    WDR41 -->|"interacts with"| Inflammation
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    WDR41 -->|"interacts with"| Amyotrophic_Lateral_Sclerosis
    WDR41 -->|"interacts with"| Als
    Dementia{"Dementia"}
    WDR41 -->|"interacts with"| Dementia
    ULK1["ULK1"]
    WDR41 -->|"associated with"| ULK1
    AMYOTROPHIC_LATERAL_SCLEROSIS["AMYOTROPHIC LATERAL SCLEROSIS"]
    WDR41 -->|"interacts with"| AMYOTROPHIC_LATERAL_SCLEROSIS
    PQLC2["PQLC2"]
    PQLC2 -->|"binds"| WDR41
    C9orf72["C9orf72"]
    C9orf72 -->|"interacts with"| WDR41
    FIP200["FIP200"]
    FIP200 -->|"associated with"| WDR41
    SMCR8 -->|"interacts with"| WDR41
    FTLD["FTLD"]
    FTLD -->|"associated with"| WDR41
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"interacts with"| WDR41
    MTORC1["MTORC1"]
    MTORC1 -->|"activates"| WDR41
    FIP200 -->|"interacts with"| WDR41
    style WDR41 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0