Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRAK1_KIF5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | TRAK1_KIF5A |
| Key Genes/Proteins | COX4I1, GAP43, GJA1, PRKAA1, RAB27A, Synthetic fusion proteins |
| Related Diseases | neurodegeneration |
| Related Pathways | Mitochondrial dynamics / bioenergetics |
graph TD
TRAK1_KIF5A["TRAK1_KIF5A"]
TRAK1_KIF5A -->|"implicated in"| neurodegeneration["neurodegeneration"]
TRAK1_KIF5A -->|"participates in"| Mitochondrial_dynamics___bioen["Mitochondrial dynamics / bioenergetics"]
TRAK1_KIF5A ---|"co-discussed"| RAB27A["RAB27A"]
TRAK1_KIF5A ---|"co-discussed"| GAP43["GAP43"]
TRAK1_KIF5A ---|"co-discussed"| TFAM["TFAM"]
TRAK1_KIF5A ---|"co-discussed"| PRKAA1["PRKAA1"]
h_346639e8["h-346639e8"] -->|"targets"| TRAK1_KIF5A
COX4I1["COX4I1"] ---|"co-discussed"| TRAK1_KIF5A
PRKAA1 ---|"co-discussed"| TRAK1_KIF5A
GJA1["GJA1"] ---|"co-discussed"| TRAK1_KIF5A
RAB27A ---|"co-discussed"| TRAK1_KIF5A
TFAM ---|"co-discussed"| TRAK1_KIF5A| Target | Relation | Type | Str |
|---|---|---|---|
| neurodegeneration | implicated_in | disease | 0.60 |
| neurodegeneration | associated_with | disease | 0.43 |
| RAB27A | co_discussed | gene | 0.40 |
| GAP43 | co_discussed | gene | 0.40 |
| TFAM | co_discussed | gene | 0.40 |
| PRKAA1 | co_discussed | gene | 0.40 |
| GJA1 | co_discussed | gene | 0.40 |
| Mitochondrial dynamics / bioenergetics | participates_in | pathway | 0.34 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-346639e8 | targets_gene | hypothesis | 0.90 |
| h-346639e8 | targets | hypothesis | 0.80 |
| PRKAA1 | debate_co_mention | gene | 0.45 |
| RAB27A | debate_co_mention | gene | 0.45 |
| Synthetic fusion proteins | debate_co_mention | gene | 0.45 |
| TFAM | debate_co_mention | gene | 0.45 |
| GJA1 | co_discussed | gene | 0.40 |
| COX4I1 | co_discussed | gene | 0.40 |
| PRKAA1 | co_discussed | gene | 0.40 |
| TFAM | co_discussed | gene | 0.40 |
| GAP43 | co_discussed | gene | 0.40 |
| GJA1 | co_associated_with | gene | 0.40 |
| RAB27A | co_associated_with | gene | 0.40 |
| PRKAA1 | co_associated_with | gene | 0.40 |
| GAP43 | co_associated_with | gene | 0.40 |
| TFAM | co_associated_with | gene | 0.40 |
| COX4I1 | co_associated_with | gene | 0.40 |
| RAB27A | co_discussed | gene | 0.40 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m | 0.621 | neurodegeneration | Mitochondrial transfer between astrocyte |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.813
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| s:** - Test MCU overexpression specifically in layer II neurons in hea | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $200,000 |
| Proposed experiment from debate on Mitochondrial transfer between astr | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Proposed experiment from debate on Mitochondrial transfer between astr | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $100,000 |
| AAV-LRRK2 IND-Enabling Study Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,500,000 |
| Axonal Transport Dysfunction Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Gap Junction Dysfunction Validation in Parkinson's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| AAV-LRRK2 Gene Therapy IND-Enabling Study Design | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Experiment Design: Metal Ion-Synuclein-Mitochondria Axis in Parkinson' | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Selective Neuronal Vulnerability to Aging — Mapping Why Specific Neuro | validation | Neurodegeneration | 0.400 | 0.50 | human | proposed | $3,000,000 |
| Synaptic Mitochondrial Resilience Enhancement for Parkinson's Disease | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $2,730,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| KIF5A de novo mutation associated with myoclonic seizures and neonatal onset pro [PMID:27414745] | Rydzanicz M, Jagła M, Kosinska J, Tomasi | Clin Genet | 2017 | 1 |
| TRAK/Milton motor-adaptor proteins steer mitochondrial trafficking to axons and [PMID:23395375] | van Spronsen M, Mikhaylova M, Lipka J, S | Neuron | 2013 | 1 |
| Delineation of the TRAK binding regions of the kinesin-1 motor proteins. [PMID:24161670] | Randall TS, Moores C, Stephenson FA | FEBS Lett | 2013 | 1 |
| Therapeutic developments in pancreatic cancer. [PMID:37798442] | ["Hu Z", "O'Reilly E"] | Nature reviews. Gastroenterolo | 2024 | 0 |
| Defining treatment-resistant depression. [PMID:31638723] | ["Gaynes B", "Lux L", "Gartlehner G", "A | Depression and anxiety | 2020 | 0 |
| Emerging trends in global freshwater availability. [PMID:29769728] | ["Rodell M", "Famiglietti J", "Wiese D", | Nature | 2018 | 0 |
| Acute Heart Failure: Definition, Classification and Epidemiology. [PMID:28785969] | ["Kurmani S", "Squire I"] | Current heart failure reports | 2017 | 0 |
| Invasive ductal carcinoma: relationship between pathological characteristics and [PMID:28658335] | ["Aquino R", "Vasques P", "Cavalcante D" | Revista do Colegio Brasileiro | 2017 | 0 |
| The Impact of Intergenerational Cultural Dissonance on Alcohol Use Among Vietnam [PMID:26598062] | ["Kane J", "Johnson R", "Robinson C", "J | The Journal of adolescent heal | 2016 | 0 |
| A proliferative burst during preadolescence establishes the final cardiomyocyte [PMID:24813607] | ["Naqvi N", "Li M", "Calvert J", "Tejada | Cell | 2014 | 0 |
| Family medicine match rate increases slightly. [PMID:22585896] | Sheri Porter | Annals of family medicine | 2012 | 0 |
| Human plasma glycome in attention-deficit hyperactivity disorder and autism spec [PMID:20974899] | ["Pivac N", "Knezevi\u0107 A", "Gornik O | Molecular & cellular proteomic | 2011 | 0 |
| The Crumbs complex: from epithelial-cell polarity to retinal degeneration. [PMID:19625503] | ["Bulgakova N", "Knust E"] | Journal of cell science | 2009 | 0 |
| CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell [PMID:18971423] | ["Landsman L", "Bar-On L", "Zernecke A", | Blood | 2009 | 0 |
| GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins [PMID:15644324] | Brickley K, Smith MJ, Beck M, Stephenson | The Journal of biological chem | 2005 | 0 |
Multi-agent debates referencing this entity