gene

PRKAA1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRKAA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

605Connections

1Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

PRKAA1 is a gene implicated in neurodegeneration research. Key relationships include: regulates, inhibits, therapeutic target. Associated with ALS, Als, Cancer. Connected to 169 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PRKAA1
Full Name	Protein Kinase AMP-Activated Catalytic Subunit Alpha 1 (AMPKα1)
Chromosome	5p13.1
Protein Type	Kinase
Target Class	Kinase
Function	Small molecule activator of AMP-activated protein kinase
Mechanism of Action	Small molecule activator of AMP-activated protein kinase
Druggability	Medium (0.55)
Clinical Stage	Approved
Amino Acids	559 aa
Exons	10
Pathways	AMPK
UniProt ID	Q13131
Ensembl ID	ENSG00000132356
GeneCards	PRKAA1
Human Protein Atlas	PRKAA1
Associated Diseases	ALS, ALZHEIMER, ALZHEIMER'S DISEASE
Known Drugs/Compounds	Metformin, metformin
Interactions	PPARGC1A, ULK1, SIRT1, GPX4, DNM1L, MTOR
SciDEX Target	View Target Profile (8 clinical trials)
SciDEX Hypotheses	AMPK hypersensitivity in astrocytes creates enhanc
KG Connections	605 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure: PRKAA1 — PDB 4QFR Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PRKAA1["PRKAA1"] -->|"associated"| neurodegeneration["neurodegeneration"]
    PRKAA1["PRKAA1"] -->|"interacts"| PPARGC1A["PPARGC1A"]
    PRKAA1["PRKAA1"] -->|"co discussed"| GJA1["GJA1"]
    PRKAA1["PRKAA1"] -->|"co discussed"| RAB27A["RAB27A"]
    PRKAA1["PRKAA1"] -->|"co discussed"| GAP43["GAP43"]
    PRKAA1["PRKAA1"] -->|"co discussed"| TFAM["TFAM"]
    PPARGC1A_1["PPARGC1A"] -->|"interacts"| PRKAA1["PRKAA1"]
    COX4I1["COX4I1"] -->|"co discussed"| PRKAA1["PRKAA1"]
    FOXP3["FOXP3"] -->|"co discussed"| PRKAA1["PRKAA1"]
    TNFA["TNFA"] -->|"co discussed"| PRKAA1["PRKAA1"]
    style PRKAA1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (380)

Target	Relation	Type	Str
Necroptosis	inhibits	process	0.95
Metformin Response	mediates	phenotype	0.90
Metformin	therapeutic_target	drug	0.90
Mitochondrial Homeostasis	regulates	process	0.90
ALZHEIMER'S DISEASE	associated_with	disease	0.85
Autophagy	involved_in	process	0.85
oxidative stress	modulates	process	0.85
Neuroinflammation	inhibits	process	0.85
TREM2	upregulates	gene	0.80
Reactive Oxygen Species	regulates	process	0.80
Parkinson's Disease	regulates	disease	0.80
AMPK_alpha1	encodes	protein	0.80
AMPK_signaling	encodes	pathway	0.80
ULK1	activates	gene	0.74
AUTOPHAGY	activates	pathway	0.74
demyelination	associated_with	phenotype	0.70
Protein Synthesis	inhibits	process	0.70
oxidative stress response	participates_in	pathway	0.70
autophagy pathway	participates_in	pathway	0.70
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Als	activates	disease	0.65
Cancer	inhibits	disease	0.65
Cardiac	inhibits	disease	0.65
Als	inhibits	disease	0.65
Als	regulates	disease	0.65
Cancer	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
ALS	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Cancer	regulates	disease	0.65
ALS	activates	disease	0.65
ALS	inhibits	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Als	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Inflammation	protects_against	disease	0.65
Alzheimer	regulates	disease	0.65
Als	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Alzheimer	inhibits	disease	0.65
Multiple Sclerosis	inhibits	disease	0.65
Parkinson	inhibits	disease	0.65
Cancer	expressed_in	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
ALS	associated_with	disease	0.65

Incoming (225)

Source	Relation	Type	Str
Metformin	activates	drug	0.95
SESN2	regulates	gene	0.95
MIR130B	inhibits	gene	0.90
h-b0cda336	targets_gene	hypothesis	0.90
h-43f72e21	targets_gene	hypothesis	0.90
MIR130B	downregulates	gene	0.85
h-b0cda336	targets	hypothesis	0.80
h-43f72e21	targets	hypothesis	0.80
Fisetin	upregulates	compound	0.80
Chlorogenic acid	upregulates	compound	0.80
MIR130B3P	inhibits	gene	0.72
SIRT1	activates	gene	0.70
metformin	targets	drug	0.70
MIR802	regulates	gene	0.64
PPARGC1A	interacts_with	gene	0.61
NRF1	therapeutic_target	gene	0.60
PPARGC1A	activates	gene	0.60
DNM1L	activates	gene	0.60
DRP1	therapeutic_target	gene	0.60
SOD2	therapeutic_target	gene	0.60
PPARGC1A	therapeutic_target	gene	0.60
SIRT3	therapeutic_target	gene	0.60
MTOR	activates	gene	0.60
ACSL4	associated_with	gene	0.60
MTOR	inhibits	gene	0.60
MFN1	therapeutic_target	gene	0.60
JUN	therapeutic_target	gene	0.60
FOXO1	therapeutic_target	gene	0.60
GPX4	inhibits	gene	0.60
DRP1	regulates	gene	0.60
CREBBP	therapeutic_target	gene	0.60
OPA1	regulates	gene	0.60
JUN	regulates	gene	0.60
MFN1	regulates	gene	0.60
NRF1	regulates	gene	0.60
SOD2	regulates	gene	0.60
PPARGC1A	regulates	gene	0.60
SIRT3	regulates	gene	0.60
CREBBP	regulates	gene	0.60
FOXO1	regulates	gene	0.60
ULK1	activates	gene	0.60
NRXN3	inhibits	gene	0.60
PDHA1	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
DNM1L	expressed_in	entity	0.60
PPARGC1A	expressed_in	entity	0.60
ACSL4	inhibits	entity	0.60
OPA1	therapeutic_target	gene	0.60
SIRT1	associated_with	gene	0.60
PRDX5	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
AMPK hypersensitivity in astrocytes creates enhanced mitocho	0.570	neurodegeneration	Mitochondrial transfer between astrocyte

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Complement C1q/C3-CR3 signaling pathway mediates abnormal microglial phagocytosi [PMID:38642614]	Han QQ, Shen SY, Liang LF, Chen XR, Yu J	Brain Behav Immun	2024	1
Metabolic orchestration of cell death by AMPK-mediated phosphorylation of RIPK1. [PMID:37384704]	Zhang T, Xu D, Trefts E, Lv M, Inuzuka H	Science	2023	1
Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK [PMID:31693892]	Wang Y, An H, Liu T, Qin C, Sesaki H, Gu	Cell Rep	2019	1
AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking Sy [PMID:30057310]	Song X, Zhu S, Chen P, Hou W, Wen Q, Liu	Curr Biol	2018	1
Mitochondrial dysfunction and Parkinson disease: a Parkin-AMPK alliance in neuro [PMID:26121488]	Hang L, Thundyil J, Lim KL	Ann N Y Acad Sci	2015	1
AMPKα1 Deficiency in Macrophages Impairs Tendon Regeneration and Tendon Stem Cel [PMID:41694579]	Zhu L, Wang Y, Shi X, Yu M, Cai X, Chen	International journal of biolo	2026	0
Single-cell transcriptome analysis reveals a cellular immune response in common [PMID:41692207]	Shi X, Ji G, Liu D, Zhao T, Tian S, Li S	International journal of biolo	2026	0
Farrerol ameliorates hepatic insulin resistance via AMPKα1/mTOR/SREBP-1 pathway: [PMID:41702183]	Li Y, Feng X, Zheng L	Tissue & cell	2026	0
Integration proteomics analysis to identify AMPK as key target pathways of TCM f [PMID:41788172]	Chen YJ, Ning DS, Wang CC, Zhao HW, Wang	Journal of traditional and com	2026	0
Baicalein limits subchondral bone lesions via AMPKα/BECN1 activation in osteoart [PMID:41791307]	Zhai Y, Zhou P, Dan L, Ma M, Liu B, Zhan	International immunopharmacolo	2026	0
Integrative SMR prioritizes oxidative stress-related regulatory genes for Alzhei [PMID:41844011]	Wu L, Dong YT, Mu X, Luo X, Chen ZJ	The journal of prevention of A	2026	0
The cholesterol 24-hydroxylase CYP46A1 promotes α-synuclein pathology in Parkins [PMID:39964974]	Dai L, Wang J, Meng L, Zhang X, Xiao T,	PLoS biology	2025	0
An ESIPT + AIE based dual-response fluorescent probe for continuous detection of [PMID:38901234]	["Zhao J", "Dai C", "Gu B", "Wei M"]	Spectrochimica acta. Part A, M	2024	0
Assessment of the Spatial Distribution of Moisture Content in Granular Material [PMID:31234567]	["Porzuczek J"]	Sensors (Basel, Switzerland)	2024	0
Schisanhenol ameliorates non-alcoholic fatty liver disease via inhibiting miR-80 [PMID:39309511]	Li B, Xiao Q, Zhao H, Zhang J, Yang C, Z	Acta pharmaceutica Sinica. B	2024	0
Retracted: Ginsenoside Rg1 Ameliorates Acute Renal Ischemia/Reperfusion Injury v [PMID:38234567]	["Longevity O"]	Oxidative medicine and cellula	2024	0
Optimal Control with RdCVFL for Degenerating Photoreceptors. [PMID:38345678]	["Wifvat K", "Camacho E", "Kawski M", "L	Bulletin of mathematical biolo	2024	0
Protective and Detoxifying Effects of Resveratrol on Zearalenone-Mediated Toxici [PMID:39456789]	["Lv Q", "Xu W", "Yang F", "Li J", "Wei	International journal of molec	2024	0
Metabolic stress induces a double-positive feedback loop between AMPK and SQSTM1 [PMID:38953310]	Choi EJ, Oh HT, Lee SH, Zhang CS, Li M,	Autophagy	2024	0
microRNA-130b-3p Attenuates Septic Cardiomyopathy by Regulating the AMPK/mTOR Si [PMID:37705752]	Qi Z, Liu R, Ju H, Huang M, Li Z, Li W,	International journal of biolo	2023	0

PRKAA1

Understanding Entity Pages

Summary

Wiki Pages (21)

PRKAA1

Neurons — Cell Type Hierarchy

Astrocyte Reactivity Mechanism

Astrocytes

Mitochondria in Neurodegeneration

Astrocyte Metabolic Enhancement Therapy for PD

Pathway Diagram

Outgoing (380)

Incoming (225)

Targeting Hypotheses (1)

Mentioning Analyses (3)

Metabolic reprogramming in neurodegenerative disease

Mitochondrial transfer between astrocytes and neurons

Digital biomarkers and AI-driven early detection of neurodegeneration

Related Papers (20)

PRKAA1

Understanding Entity Pages

Summary

Wiki Pages (21)

PRKAA1

Neurons — Cell Type Hierarchy

Astrocyte Reactivity Mechanism

Astrocytes

Mitochondria in Neurodegeneration

Astrocyte Metabolic Enhancement Therapy for PD

Mitochondria-Lysosome Contact Site Dysfunction in Parkinson's Disease

Biomarkers of Alzheimer Disease

Biomarker-Therapeutic Development Nexus

Astrocyte Reactivity in 4R-Tauopathies

Astrocyte-Neuron Metabolic Coupling Pathway

Nicotinamide Riboside

Astrocyte-Mediated Neuroinflammation

Biomarkers in Neurodegeneration

Mitochondria-Lysosome Contact Site Dysfunction in Parkinson's Disease

Biomarkers for Parkinson's Disease

Astrocyte Senescence Pathway in Neurodegeneration

Mitochondria-Lysosome Contact Sites (MLCS) in Neurodegeneration

Mitochondria-Lysosome Contact Sites in Parkinson's Disease

Biomarkers for Corticobasal Degeneration

Sirtuin Modulators for Parkinson's Disease

Pathway Diagram

Outgoing (380)

Incoming (225)

Targeting Hypotheses (1)

Mentioning Analyses (3)

Metabolic reprogramming in neurodegenerative disease

Mitochondrial transfer between astrocytes and neurons

Digital biomarkers and AI-driven early detection of neurodegeneration

Related Papers (20)