Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Mitochondrial dynamics / bioenergetics: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| CGAS | participates_in | gene | 0.54 |
| STING1 | participates_in | gene | 0.54 |
| DNASE2 | participates_in | gene | 0.54 |
| COX4I1 | participates_in | gene | 0.47 |
| TFAM | participates_in | gene | 0.46 |
| MIRO1 | participates_in | gene | 0.43 |
| RAB27A | participates_in | gene | 0.41 |
| GJA1 | participates_in | gene | 0.41 |
| SYNCRIP | participates_in | gene | 0.40 |
| GAP43 | participates_in | gene | 0.38 |
| ALOX5 | participates_in | gene | 0.36 |
| TRAK1_KIF5A | participates_in | gene | 0.34 |
Hypotheses where this entity is a therapeutic target
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.833
neurodegeneration | 2026-04-01 | 13 hypotheses Top: 0.720
neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.791
neurodegeneration | 2026-04-01 | 15 hypotheses Top: 0.822
neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.741
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| iPSC-derived astrocyte-neuron co-culture mitochondrial transfer in PD | exploratory | Parkinson's disease | 0.900 | 0.00 | iPSC-derived dopaminergic neur | proposed | N/A |
| IRI-AKI mouse model with mtROS inhibition | validation | ischemic acute kidney injury | 0.900 | 0.00 | IRI-AKI mice | proposed | N/A |
| mtROS effects on TFAM and mtDNA in HK2 cells | exploratory | acute kidney injury | 0.900 | 0.00 | HK2 cells | proposed | N/A |
| TFAM knockdown functional analysis | exploratory | acute kidney injury | 0.850 | 0.00 | HK2 cells | proposed | N/A |
| TFAM and mtDNA analysis in AKI patients | clinical | acute kidney injury | 0.800 | 0.00 | human patients | proposed | N/A |
| Rab27a knockdown effects on microglia activation in developing brain | validation | 0.800 | 0.00 | Neonatal mice with dorsal subv | proposed | N/A | |
| Proposed experiment from debate on Senolytics targeting p16/p21+ senes | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Biomechanical Impact Profiles and Chronic Traumatic Encephalopathy Phe | clinical | Neurodegeneration | 0.400 | 0.50 | in_silico | proposed | $180,000 |
| Sporadic ALS Initiation Biology: Deep Phenotyping of At-Risk Cohorts | clinical | ALS | 0.400 | 0.50 | human | proposed | $6,550,000 |
| cGAS-STING Pathway Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $7,100,000 |
| Mixed Pathology Effects on Parkinson's Disease Progression and Treatme | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| NLRP3 Inflammasome Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Regulated Necrosis Validation Study in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| Senolytic Therapy (D+Q) Phase IIa Trial in Early Alzheimer's Disease | clinical | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $5,460,000 |
| Traumatic Brain Injury and Alzheimer's Disease Relationship | validation | Alzheimer's Disease | 0.400 | 0.50 | human | proposed | $3,000,000 |
| s:** - Test MCU overexpression specifically in layer II neurons in hea | falsification | Neurodegeneration | 0.400 | 0.50 | mouse | proposed | $200,000 |
| Proposed experiment from debate on Mitochondrial transfer between astr | falsification | Neurodegeneration | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| Mechanism: Selective Vulnerability of Dopaminergic Neurons in Parkinso | validation | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $3,000,000 |
| Ferroptosis Validation in Parkinson's Disease | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
| GLP-1 Agonist Neuroprotection Mechanism in PD | clinical | Parkinson's Disease | 0.400 | 0.50 | human | proposed | $6,550,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Organelle-specific autophagy in inflammatory diseases: a potential therapeutic t [PMID:32048886] | Yao RQ, Ren C, Xia ZF, Yao YM | Autophagy | 2021 | 2 |
| TDP-43 Triggers Mitochondrial DNA Release via mPTP to Activate cGAS/STING in ALS [PMID:33031745] | Yu CH, Davidson S, Harapas CR, Hilton JB | Cell | 2020 | 2 |
| Allosteric properties of mammalian ALOX15 orthologs. [PMID:41654134] | Yang J, Borchert A, Kuhn H | J Biol Chem | 2026 | 1 |
| Miro1: A potential target for treating neurological disorders. [PMID:40403957] | Zeng L, Yang J, Zhang C, Zhu J, Zhong S, | Neuroscience | 2025 | 1 |
| Imp/IGF2BP and Syp/SYNCRIP temporal RNA interactomes uncover combinatorial netwo [PMID:39919181] | Lee JY, Huang N, Samuels TJ, Davis I | Sci Adv | 2025 | 1 |
| Calcium-Associated Proteins in Neuroregeneration. [PMID:38397420] | Lisek M, Tomczak J, Boczek T, Zylinska L | Biomolecules | 2024 | 1 |
| Melatonin attenuates sepsis-induced acute kidney injury by promoting mitophagy t [PMID:37651673] | Deng Z, He M, Hu H, Zhang W, Zhang Y, Ge | Autophagy | 2024 | 1 |
| TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic [PMID:38783142] | Liu H, Zhen C, Xie J, Luo Z, Zeng L, Zha | Nat Cell Biol | 2024 | 1 |
| SBFI26 induces triple-negative breast cancer cells ferroptosis via lipid peroxid [PMID:38516826] | He G, Zhang Y, Feng Y, Chen T, Liu M, Ze | J Cell Mol Med | 2024 | 1 |
| Mitochondria from osteolineage cells regulate myeloid cell-mediated bone resorpt [PMID:38877020] | Ding P, Gao C, Zhou J, Mei J, Li G, Liu | Nat Commun | 2024 | 1 |
| Increased mitophagy protects cochlear hair cells from aminoglycoside-induced dam [PMID:35471096] | Zhang Y, Fang Q, Wang H, Qi J, Sun S, Li | Autophagy | 2023 | 1 |
| RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoi [PMID:37085479] | Herrejon Chavez F, Luo H, Cifani P, Pine | Nat Commun | 2023 | 1 |
| Tumour extracellular vesicles and particles induce liver metabolic dysfunction. [PMID:37225988] | Wang G, Li J, Bojmar L, Chen H, Li Z, To | Nature | 2023 | 1 |
| Selective inhibition of cannabinoid CB(1) receptor-evoked signalling by the inte [PMID:37689260] | Maroto IB, Moreno E, Costas-Insua C, Mer | Neuropharmacology | 2023 | 1 |
| Extracellular vesicles in fatty liver promote a metastatic tumor microenvironmen [PMID:37172577] | Wang Z, Kim SY, Tu W, Kim J, Xu A, Yang | Cell Metab | 2023 | 1 |
| Mitochondrial-derived damage-associated molecular patterns amplify neuroinflamma [PMID:35233090] | Lin MM, Liu N, Qin ZH, Wang Y | Acta Pharmacol Sin | 2022 | 1 |
| lncRNA LOC100911717-targeting GAP43-mediated sympathetic remodeling after myocar [PMID:36684596] | Li P, Wang K, Yin J, Qi L, Hu H, Yang P, | Front Cardiovasc Med | 2022 | 1 |
| Mitochondrial ROS promote mitochondrial dysfunction and inflammation in ischemic [PMID:33408785] | Zhao M, Wang Y, Li L, Liu S, Wang C, Yua | Theranostics | 2021 | 1 |
| Machine Learning and Novel Biomarkers for the Diagnosis of Alzheimer's Disease. [PMID:33803217] | Chang CH, Lin CH, Lane HY | Int J Mol Sci | 2021 | 1 |
| Mitochondrial DNA copy number in human disease: the more the better? [PMID:33314045] | Filograna R, Mennuni M, Alsina D, Larsso | FEBS Lett | 2021 | 1 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.40 · 2026-04-27
closed · Rounds: 4 · Score: 0.72 · 2026-04-12
closed · Rounds: 4 · Score: 0.95 · 2026-04-10
closed · Rounds: 4 · Score: 0.89 · 2026-04-06
closed · Rounds: 4 · Score: 0.83 · 2026-04-06
closed · Rounds: 4 · Score: 0.88 · 2026-04-06
closed · Rounds: 4 · Score: 0.95 · 2026-04-06
Hypotheses and analyses mentioning Mitochondrial dynamics / bioenergetics in their description or question text
Score: 0.674 · neurodegeneration · 2026-04-02
## Mechanistic Overview RAB27A-dependent extracellular vesicle engineering for mitochondrial cargo delivery starts from
Score: 0.666 · neurodegeneration · 2026-04-02
## Mechanistic Overview GAP43-mediated tunneling nanotube stabilization enhances neuroprotective mitochondrial transfer
Score: 0.656 · neurodegeneration · 2026-04-02
## Mechanistic Overview Mitochondrial RNA Granule Rescue Pathway starts from the claim that modulating SYNCRIP within th
Score: 0.647 · neurodegeneration · 2026-04-02
## Mechanistic Overview Mitochondrial SPM Synthesis Platform Engineering starts from the claim that modulating ALOX5 wit
Score: 0.621 · neurodegeneration · 2026-04-02
## Mechanistic Overview Designer TRAK1-KIF5 fusion proteins accelerate therapeutic mitochondrial delivery starts from th
Score: 0.566 · neurodegeneration · 2026-04-02
## Mechanistic Overview CX43 hemichannel engineering enables size-selective mitochondrial transfer starts from the claim