Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRANSFERRIN RECEPTOR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| BLOOD-BRAIN BARRIER | mediates | entity | 0.95 |
| FERROPTOSIS | biomarker_for | entity | 0.95 |
| Ferroptosis | associated_with | process | 0.95 |
| IRON UPTAKE | mediates | entity | 0.90 |
| Ferroptosis | involved_in | process | 0.90 |
| Ferroptotic Cell Death | mediates | process | 0.85 |
| Iron Homeostasis | regulates | process | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| CHRONIC CEREBRAL HYPOPERFUSION | upregulates | entity | 0.95 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Magnetosonic-Triggered Transferrin Receptor Clustering | 0.470 | neurodegeneration | Blood-brain barrier transport mechanisms |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.566
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Bispecific brain-penetrant antibodies for treatment of Alzheimer's disease. [PMID:40425446] | Sehlin D, Hultqvist G, Michno W, Aguilar | J Prev Alzheimers Dis | 2025 | 1 |
| Effect of ferroptosis on chronic cerebral hypoperfusion in vascular dementia. [PMID:37709116] | Fu P, Chen Y, Wu M, Bao B, Yin X, Chen Z | Exp Neurol | 2023 | 1 |
| On Iron Metabolism and Its Regulation. [PMID:33925597] | Vogt AS, Arsiwala T, Mohsen M, Vogel M, | Int J Mol Sci | 2021 | 1 |
| Transferrin Receptor Is a Specific Ferroptosis Marker. [PMID:32160546] | Feng H, Schorpp K, Jin J, Yozwiak CE, Ho | Cell Rep | 2020 | 1 |
| Transferrin and transferrin receptors update. [PMID:29969719] | Kawabata H | Free Radic Biol Med | 2019 | 1 |
| A proimmunotoxin nanodrug targeting AIDS-associated non-Hodgkin lymphoma. [PMID:41592623] | Chen S, Qi T, Peng H, Kimura E, Zhang X | J Control Release | 2026 | 0 |
| Time- and dose-dependent effects of bacterial infection on iron metabolism, infl [PMID:41619877] | Lu Y, Zhang Y, Niu C | Comp Biochem Physiol A Mol Int | 2026 | 0 |
| Ayanin combats against barium sulphate nanoparticles induced hepatotoxicity via [PMID:41666660] | Zhu D, Lu Y, Jamil S, Ashfaq H, Al-Emam | J Trace Elem Med Biol | 2026 | 0 |
| Role of iron and TfR1 in the application of high‑dose ascorbate against pancreat [PMID:41789665] | Piotrowsky A, Leischner C, Schmieder H, | Oncol Rep | 2026 | 0 |
| Brain and Liver Dual-Targeting Oridonin Nanoparticles to Enhance Aβ Clearance fo [PMID:41944296] | Gong W, Hui W, Qiao S, Ji Q, Liu M et al | Adv Sci (Weinh) | 2026 | 0 |
| Cerebrospinal Fluid from Restless Legs Syndrome Patients Reduces Iron Uptake in [PMID:41947413] | Palsa K, Sahu AP, Rye DB, Trotti LM, Elc | Ann Neurol | 2026 | 0 |
| Pulmonary neuroendocrine cell-derived exosomes regulate iron homeostasis and oxi [PMID:41950316] | Thakur A, Zhang K, Chen J, Mei S, Chen J | Sci Adv | 2026 | 0 |
| O-GlcNAc Modification Orchestrates HUWE1-Mediated Ubiquitination of TfR1 to Regu [PMID:41962599] | Zhang H, Li M, Zhang J, Sun Q, Jin X et | Free Radic Biol Med | 2026 | 0 |
| Protective Role of Polydatin Against Vancomycin-Induced Lung Toxicity via Oxidat [PMID:41963266] | Aygörmez S, Küçükler S, Çomaklı S, Şimşe | J Appl Toxicol | 2026 | 0 |
| Yangxin granules exert cardioprotective effects against acute myocardial infarct [PMID:41868900] | Huo G, Zhou Y, Wu Z, Sun S, Zhu G, Cheng | American journal of translatio | 2026 | 0 |
| Conformational dynamics study of TfR1 upon transferrin binding via NMA and MD si [PMID:41921418] | Zemmouche M, Falque G, Cadet F, Gardebie | Journal of molecular graphics | 2026 | 0 |
| [Effects of acupuncture on ferroptosis and ferritinophagy in cerebral ischemia-r [PMID:41839581] | Wang YF, Dong YS | Zhen ci yan jiu = Acupuncture | 2026 | 0 |
| The therapeutic potential of Piezo1 channel-mediated ferroptosis and its inhibit [PMID:41854751] | Nan K, Zhang L, Zhao Y, Yin S, Peng Y, H | Apoptosis : an international j | 2026 | 0 |
| The Role of Artemisinin and its Derivatives in Cancer Therapy via Ferroptosis: A [PMID:41833023] | Osmanlioglu Dag SR, Tatli Cankaya II, Oz | Anti-cancer agents in medicina | 2026 | 0 |
| Raccoon eyes. [PMID:35789012] | Ning J | Journal of paediatrics and chi | 2023 | 0 |