concept

IRON HOMEOSTASIS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IRON HOMEOSTASIS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

29Connections

1Hypotheses

1Analyses

9Outgoing

20Incoming

0Experiments

1Debates

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💡 Concept Info

Name	IRON HOMEOSTASIS

Pathway Diagram

graph TD
    IRON_HOMEOSTASIS["IRON HOMEOSTASIS"]
    IRON_HOMEOSTASIS -->|"regulates"| Cell_Damage["Cell Damage"]
    IRON_HOMEOSTASIS -->|"regulates"| Brain_Ageing["Brain Ageing"]
    IRON_HOMEOSTASIS -->|"regulates"| Erythropoiesis["Erythropoiesis"]
    ferritinophagy["ferritinophagy"] -->|"modulates"| IRON_HOMEOSTASIS
    IRP_IRE_network["IRP-IRE network"] -->|"regulates"| IRON_HOMEOSTASIS
    IRP2["IRP2"] -->|"regulates"| IRON_HOMEOSTASIS
    Ferritinophagy["Ferritinophagy"] -->|"regulates"| IRON_HOMEOSTASIS
    NRF2["NRF2"] -->|"regulates"| IRON_HOMEOSTASIS
    HIF["HIF"] -->|"regulates"| IRON_HOMEOSTASIS
    TFRC["TFRC"] -->|"regulates"| IRON_HOMEOSTASIS
    SNCA["SNCA"] -->|"interacts"| IRON_HOMEOSTASIS

Outgoing (9)

Target	Relation	Type	Str
Parkinson's Disease	associated_with	disease	0.95
Amyotrophic Lateral Sclerosis	associated_with	disease	0.95
Alzheimer's Disease	associated_with	disease	0.95
Parkinson's disease	associated_with	disease	0.92
Cell Damage	regulates	phenotype	0.85
Brain Ageing	regulates	phenotype	0.80
Erythropoiesis	regulates	process	0.80
Alzheimer's Disease	implicated_in	disease	0.75
mitochondrial function	regulates	process	0.75

Incoming (20)

Source	Relation	Type	Str
ferritinophagy	modulates	process	0.95
IRP-IRE network	regulates	pathway	0.90
FTH1	regulates	protein	0.90
FTMT	regulates	protein	0.90
IRP2	regulates	protein	0.90
NCOA4	regulates	gene	0.90
bacterial siderophore synthesis	regulates	process	0.90
SLC45A1	regulates	protein	0.90
Ferritinophagy	regulates	process	0.90
LCN2	regulates	protein	0.85
Quercetin	regulates	compound	0.85
SNCA	interacts_with	gene	0.85
MAPT	interacts_with	gene	0.85
APP	interacts_with	gene	0.85
HIF	regulates	protein	0.85
NRF2	regulates	gene	0.85
TfR1	involved_in	protein	0.85
SLC45A1 loss	associated_with	phenotype	0.80
TRANSFERRIN RECEPTOR	regulates	protein	0.80
FPNL	regulates	protein	0.80

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Labile iron pool expansion amplifies genotype-specific ALS f	0.664	neurodegeneration	Ferroptosis in ALS motor neuron vulnerab

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why does iron chelation therapy worsen outcomes in H63D HFE variant carriers des

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.586

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The study shows deferiprone rescues wild-type cells but exacerbates toxicity in

closed · Rounds: 4 · Score: 0.95 · 2026-04-15

Related Research

Hypotheses and analyses mentioning IRON HOMEOSTASIS in their description or question text

No additional research found