TREK1

Understanding Entity Pages

This page aggregates everything SciDEX knows about TREK1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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graph TD
    TREK1["TREK1"]
    TREK1 -->|"regulates"| Blood_Brain_Barrier_Function["Blood-Brain Barrier Function"]
    TREK1 -->|"inhibits"| Lymphocyte_Migration["Lymphocyte Migration"]
    TREK1 -->|"expressed in"| Brain_Endothelial_Cells["Brain Endothelial Cells"]
    TREK1 -->|"involved_in"| Depression["Depression"]
    TREK1 -->|"involved_in"| Pain["Pain"]
    TREK1 -->|"involved_in"| Neurodegenerative_Damage["Neurodegenerative Damage"]
    TREK1 -->|"regulates"| MEMBRANE_POTENTIAL["MEMBRANE_POTENTIAL"]
    TREK1 -->|"regulates"| CELLULAR_EXCITABILITY["CELLULAR_EXCITABILITY"]
    KCNK2["KCNK2"] -->|"encodes"| TREK1
    Inflammation["Inflammation"] -->|"downregulates"| TREK1
    PRNP["PRNP"] -->|"binds"| TREK1
    PRIONPROTEINPRP["PRIONPROTEINPRP"] -->|"binds"| TREK1
    FMRPPROTEIN["FMRPPROTEIN"] -->|"binds"| TREK1
    RPS3A["RPS3A"] -->|"interacts"| TREK1
    GABAARECEPTORTHETAPROTEIN["GABAARECEPTORTHETAPROTEIN"] -->|"binds"| TREK1