disease

Pain

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Pain: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

283Connections

1Hypotheses

1Analyses

20Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	AND, MITOCHONDRIAL DYSFUNCTION, MITOCHONDRIA, NFL, NEURON, GFP, VEGF, STROKE
Therapeutic Agents	Cannabigerol, CBG
KG Connections	282 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    Pain["Pain"] -->|"regulates"| Immune_Response["Immune Response"]
    style Immune_Response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Pain["Pain"] -->|"activates"| Mitochondrial_Function["Mitochondrial Function"]
    style Mitochondrial_Function fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Pain["Pain"] -->|"activates"| Oxidative_Stress["Oxidative Stress"]
    style Oxidative_Stress fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Pain["Pain"] -->|"activates"| Glycolysis["Glycolysis"]
    style Glycolysis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Pain["Pain"] -->|"activates"| Apoptosis["Apoptosis"]
    style Apoptosis fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Pain["Pain"] -->|"activates"| Mitophagy["Mitophagy"]
    style Mitophagy fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    Pain["Pain"] -->|"regulates"| Circadian_Rhythm["Circadian Rhythm"]
    style Circadian_Rhythm fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    n_815_Gene_Expression_Module["815-Gene Expression Module"] -->|"biomarker for"| Pain["Pain"]
    style n_815_Gene_Expression_Module fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    Cannabigerol["Cannabigerol"] -->|"treats"| Pain["Pain"]
    style Cannabigerol fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TREK1["TREK1"] -->|"involved in"| Pain["Pain"]
    style TREK1 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    TNF["TNF"] -->|"regulates"| Pain["Pain"]
    style TNF fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    IL_4["IL-4"] -->|"regulates"| Pain["Pain"]
    style IL_4 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Pain fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (20)

Target	Relation	Type	Str
Immune Response	regulates	pathway	0.55
Mitochondrial Function	activates	pathway	0.55
Oxidative Stress	activates	pathway	0.55
Glycolysis	activates	pathway	0.55
Apoptosis	activates	pathway	0.55
Mitophagy	activates	pathway	0.55
Circadian Rhythm	regulates	pathway	0.55
Blood-Brain Barrier	expressed_in	pathway	0.55
Amyloid	therapeutic_target	pathway	0.55
Autophagy	therapeutic_target	pathway	0.55
Mapk	therapeutic_target	pathway	0.55
NEUTROPHILS	activates	concept	0.50
AMYGDALA	interacts_with	concept	0.50
AMYGDALA	inhibits	concept	0.50
Proteins	associated_with	protein	0.50
Proteins	interacts_with	protein	0.50
GENE EXPRESSION	interacts_with	concept	0.50
METFORMIN	associated_with	concept	0.50
ST3GAL2	associated_with	concept	0.50
NUCLEUS	expressed_in	concept	0.50

Incoming (263)

Source	Relation	Type	Str
Gene Expression Module	associated_with	biomarker	0.95
Inflammation	causes	process	0.95
815-Gene Expression Module	biomarker_for	biomarker	0.92
Sensory Nerve Growth	associated_with	process	0.90
CBG	modulates	compound	0.85
Cannabigerol	treats	compound	0.82
KCNK2	implicated_in	gene	0.80
TREK1	involved_in	protein	0.75
KCNK2	involved_in	gene	0.70
TNF	regulates	gene	0.65
IL-4	regulates	gene	0.65
AND	regulates	gene	0.65
IL-10	regulates	gene	0.65
CYTOKINES	regulates	gene	0.65
IFN	regulates	gene	0.65
TNF	therapeutic_target	gene	0.65
NEURODEGENERATIVE DISEASES	therapeutic_target	gene	0.65
AND	therapeutic_target	gene	0.65
PARKINSON	activates	gene	0.65
MTDNA	activates	gene	0.65
TFAM	activates	gene	0.65
NRF1	activates	gene	0.65
HUNTINGTON	activates	gene	0.65
DNA	activates	gene	0.65
ATP	activates	gene	0.65
OXIDATIVE STRESS	activates	gene	0.65
AMPK	activates	gene	0.65
PARKIN	activates	gene	0.65
EXERCISE	activates	gene	0.65
ALZHEIMER	activates	gene	0.65
ROS	activates	gene	0.65
SIRT1	activates	gene	0.65
LRRK2	activates	gene	0.65
EPILEPSY	activates	gene	0.65
NRF2	activates	gene	0.65
INSULIN RESISTANCE	activates	gene	0.65
DJ-1	activates	gene	0.65
PINK1	activates	gene	0.65
CANCER	activates	gene	0.65
AND	associated_with	gene	0.65
GENES	activates	gene	0.65
MITOCHONDRIAL DYSFUNCTION	associated_with	gene	0.65
NEURODEGENERATIVE DISEASES	activates	gene	0.65
MITOPHAGY	activates	gene	0.65
PPAR	activates	gene	0.65
MITOCHONDRIA	associated_with	gene	0.65
MITOCHONDRIAL DNA	activates	gene	0.65
APOPTOSIS	activates	gene	0.65
GENE MUTATIONS	activates	gene	0.65
NFL	causes	gene	0.65

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Dual Calpain/Cathepsin B Inhibition as Primary Neuroprotecti	0.557	neurodegeneration	Why does autophagy inhibition improve ne

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why does autophagy inhibition improve neuronal survival when autophagy is typica

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.557

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Pain

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Corticobasal Syndrome (CBS)

Parkinson's Disease

Device Therapies Comparison for CBS/PSP

CBS/PSP Rehabilitation Master Guide

nimodipine-als

Therapeutics

nct07165106

Astrocyte Reactivity Mechanism

Growth Factor Therapies

CBS/PSP Clinical Trials Guide

Neurotrophin Signaling Pathways in Neurodegeneration

protective-strategies-cbs-psp

Spinal Cord Dorsal Horn Neurons

nf1-protein

deferiprone-neurodegeneration

dimethyl-fumarate-nrf2-ad-nct06850597