gene

PRNP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PRNP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

111Connections

0Hypotheses

1Analyses

50Outgoing

43Incoming

0Experiments

1Debates

Summary

PRNP encodes the prion protein; mutations cause genetic prion disease and PrP acts as a receptor for amyloid-beta in Alzheimer's disease

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🧬 Gene Info

Gene Symbol	PRNP
Full Name	Prion Protein
Chromosome	20p13
Function	is a gene located on chromosome 20p13 that encodes the major prion protein (PrP), a glycosylphosphatidylinositol (GPI)-anchored glycoprotein of 253 amino acids[@genetic2003].
Primary Expression	Cerebral cortex, Cerebellum, Hippocampus, Thalamus, Basal ganglia, Brainstem
Amino Acids	253 aa
Pathways	Amyloid
UniProt ID	P04156
NCBI Gene ID	5621
Ensembl ID	ENSG00000171867
OMIM	176640
GeneCards	PRNP
Human Protein Atlas	PRNP
Associated Diseases	Aging, Als, Alzheimer, Creutzfeldt-Jakob, frontotemporal dementia
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, APP, BACE1, BDNF, CTSB
KG Connections	111 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: PRNP — AlphaFold P04156 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PRNP["PRNP"]
    TREK1["TREK1"]
    PRNP -->|"binds"| TREK1
    Alzheimer{"Alzheimer"}
    PRNP -->|"activates"| Alzheimer
    Ms{"Ms"}
    PRNP -->|"activates"| Ms
    neurodegeneration["neurodegeneration"]
    PRNP -->|"implicated in"| neurodegeneration
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"activates"| PRNP
    TAU["TAU"]
    TAU -->|"activates"| PRNP
    style PRNP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (68)

Target	Relation	Type	Str
Prion disease	therapeutic_target_for	disease	0.90
Neuroprotection	mediates	process	0.80
mood disorder	protects_against	disease	0.80
TREK1	binds	protein	0.80
ALS	associated_with	disease	0.65
Aging	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	associated_with	disease	0.65
Ms	activates	disease	0.65
Alzheimer	activates	disease	0.65
Creutzfeldt-Jakob	associated_with	disease	0.65
Prion Disease	associated_with	disease	0.65
Aging	associated_with	disease	0.65
IL6	associated_with	gene	0.60
IL1A	associated_with	gene	0.60
SNCA	activates	gene	0.60
TH	activates	gene	0.60
TBK1	implicated_in	gene	0.60
SIGMAR1	causes	gene	0.60
SQSTM1	causes	gene	0.60
TARDBP	causes	gene	0.60
TBK1	causes	gene	0.60
TMEM106B	causes	gene	0.60
UBQLN2	causes	gene	0.60
VCP	causes	gene	0.60
PROTEIN MISFOLDING	associated_with	gene	0.60
Neuron	associated_with	cell_type	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
GENES	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
Amyloid	regulates	pathway	0.60
TFCP2	associated_with	gene	0.60
IDE	associated_with	gene	0.60
TGFB1	associated_with	gene	0.60
BACE1	associated_with	gene	0.60
HSPG2	associated_with	gene	0.60
IL10	associated_with	gene	0.60
ACE	associated_with	gene	0.60
SORL1	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
PLAU	associated_with	gene	0.60
Prion Protein	therapeutic_target	protein	0.60
Prion Protein	associated_with	protein	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
Neuron	therapeutic_target	cell_type	0.60
Bdnf	associated_with	protein	0.60
Amyloid Beta	regulates	protein	0.60

Incoming (43)

Source	Relation	Type	Str
Air Pollution	downregulates	compound	0.90
TGFB1	associated_with	gene	0.60
ABCA7	implicated_in	gene	0.60
CHCHD2	causes	gene	0.60
CHMP2B	causes	gene	0.60
CYLD	causes	gene	0.60
FUS	causes	gene	0.60
GRN	causes	gene	0.60
MAPT	causes	gene	0.60
OPTN	causes	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
SORL1	associated_with	gene	0.60
IL1A	associated_with	gene	0.60
IL10	associated_with	gene	0.60
PLAU	associated_with	gene	0.60
BDNF	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
IL6	associated_with	gene	0.60
ACE	associated_with	gene	0.60
HSPG2	associated_with	gene	0.60
AMYLOID	regulates	gene	0.60
MAPT	activates	gene	0.60
ANXA11	causes	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
TFCP2	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
TAU	activates	gene	0.60
IDE	associated_with	gene	0.60
BACE1	associated_with	gene	0.60
CCNF	causes	gene	0.60
CHCHD10	causes	gene	0.60
APP	activates	gene	0.60
CTSB	activates	gene	0.60
CTSD	activates	gene	0.60
GBA	activates	gene	0.60
LAMP1	activates	gene	0.60
BDNF	interacts_with	gene	0.50
TGFB1	interacts_with	gene	0.50
IL10	interacts_with	gene	0.50
PLAU	interacts_with	gene	0.50
MAPT	interacts_with	gene	0.50
PSEN1	interacts_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How can CRISPR systems achieve persistent therapeutic effects while avoiding chr

gene therapy | 2026-04-11 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate highlighted that long-term CRISPR expression triggers immune response

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning PRNP in their description or question text

No additional research found