TREM2_protein

Understanding Entity Pages

This page aggregates everything SciDEX knows about TREM2_protein: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

A protein referenced in 7 knowledge graph relationships. Key connections: TREM2 (gene) encodes; activates DAP12 (protein); required_for DAM_transition (mechanism).

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flowchart TD
    N0["TREM2 PROTEIN"]
    N1["ALZHEIMER"]
    N0 -->|"activates"| N1
    N2["Alzheimer'S Disease"]
    N0 -->|"activates"| N2
    N3["disease"]
    N0 -->|"activates"| N3
    N4["ALZHEIMER'S"]
    N0 -->|"activates"| N4
    N5["Cortex"]
    N0 -.->|"inhibits"| N5
    N6["Hippocampus"]
    N0 -.->|"inhibits"| N6
    N7["FRONTAL"]
    N0 -.->|"inhibits"| N7
    N8["TREM2"]
    N8 -->|"activates"| N0
    N9["late"]
    N9 -->|"activates"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 gene
    class N2 disease
    class N3 disease
    class N8 gene
    class N9 disease