protein

TREM2_protein

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TREM2_protein: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

35Connections

0Hypotheses

1Analyses

30Outgoing

5Incoming

0Experiments

1Debates

Summary

A protein referenced in 7 knowledge graph relationships. Key connections: TREM2 (gene) encodes; activates DAP12 (protein); required_for DAM_transition (mechanism).

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🔬 Protein Info

Gene Symbol	TREM2-PROTEIN
Aliases	TREM2_protein
GeneCards	TREM2-PROTEIN
Human Protein Atlas	TREM2-PROTEIN
Associated Diseases	alzheimer_disease, alzheimers, neurodegeneration
Interactions	APOE4, DAP12, SYK_kinase
KG Connections	35 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

flowchart TD
    N0["TREM2 PROTEIN"]
    N1["ALZHEIMER"]
    N0 -->|"activates"| N1
    N2["Alzheimer'S Disease"]
    N0 -->|"activates"| N2
    N3["disease"]
    N0 -->|"activates"| N3
    N4["ALZHEIMER'S"]
    N0 -->|"activates"| N4
    N5["Cortex"]
    N0 -.->|"inhibits"| N5
    N6["Hippocampus"]
    N0 -.->|"inhibits"| N6
    N7["FRONTAL"]
    N0 -.->|"inhibits"| N7
    N8["TREM2"]
    N8 -->|"activates"| N0
    N9["late"]
    N9 -->|"activates"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
    class N1 gene
    class N2 disease
    class N3 disease
    class N8 gene
    class N9 disease

Outgoing (30)

Target	Relation	Type	Str
alzheimer_disease	associated_with	disease	0.95
alzheimer_disease	implicated_in	disease	0.95
microglial_activation	regulates	mechanism	0.95
alzheimer_disease	increases_risk	disease	0.95
neurodegeneration	associated_with	disease	0.90
neuroinflammation	involved_in	mechanism	0.90
alzheimers	increases_risk	disease	0.90
APOE4	co_expressed_with	protein	0.85
microglial_activation	mediates	mechanism	0.85
synaptic_plasticity	mediates	mechanism	0.85
alzheimers	implicated_in	disease	0.85
microglial_activation	involved_in	mechanism	0.85
neuroinflammation	modulates	mechanism	0.85
synapse_injury	modulates	unknown	0.83
recognition_memory	modulates	unknown	0.82
neuroinflammation	mediates	mechanism	0.80
phagocytosis	mediates	mechanism	0.80
glymphatic_clearance	contributes_to	mechanism	0.80
neurodegeneration	implicated_in	disease	0.80
neurodegeneration	modulates	disease	0.80
phagocytosis	involved_in	mechanism	0.80
TDP-43_aggregation	correlates_with	phenotype	0.75
DAP12	interacts_with	protein	0.75
alpha_synuclein_aggregation	associated_with	mechanism	0.75
microglial_activation	modulates	mechanism	0.75
microglial_activation	implicated_in	mechanism	0.75
glymphatic_clearance	involved_in	mechanism	0.75
SYK_kinase	interacts_with	protein	0.70
protein_aggregation	inhibits	process	0.60
microglial_clearance	promotes	process	0.60

Incoming (5)

Source	Relation	Type	Str
mutant THAP11	upregulates	unknown	0.92
APOE4	interacts_with	protein	0.85
APOE4	modulates	protein	0.75
microglial_activation	involved_in	mechanism	0.68
TREM2	encodes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Protein aggregation cross-seeding across neurodegenerative diseases

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.639

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

What are the mechanisms underlying protein aggregation cross-seeding across neur

closed · Rounds: 4 · Score: 0.95 · 2026-04-01

Related Research

Hypotheses and analyses mentioning TREM2_protein in their description or question text

No additional research found