DAP12

Understanding Entity Pages

This page aggregates everything SciDEX knows about DAP12: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

A protein referenced in 3 knowledge graph relationships. Key connections: TYROBP (gene) encodes; recruits SYK_kinase (protein); TREM2_protein (protein) activates.

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graph TD
    DAP12["<b>DAP12</b>"]
    Alzheimer{"Alzheimer"}
    DAP12 -->|"activates"| Alzheimer
    ALS{"ALS"}
    DAP12 -->|"activates"| ALS
    DAP12 -->|"associated with"| Alzheimer
    Tauopathy{"Tauopathy"}
    DAP12 -->|"interacts with"| Tauopathy
    Ms{"Ms"}
    DAP12 -->|"activates"| Ms
    ALZHEIMER["ALZHEIMER"]
    DAP12 -->|"activates"| ALZHEIMER
    TREM2["TREM2"]
    DAP12 -->|"activates"| TREM2
    Amyloid(["Amyloid"])
    DAP12 -->|"activates"| Amyloid
    Apoptosis(["Apoptosis"])
    DAP12 -->|"activates"| Apoptosis
    OVERVIEW["OVERVIEW"]
    DAP12 -->|"interacts with"| OVERVIEW
    MICROGLIA["MICROGLIA"]
    DAP12 -->|"associated with"| MICROGLIA
    DAP12 -->|"associated with"| ALZHEIMER
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| DAP12
    AMYLOID["AMYLOID"]
    AMYLOID -->|"activates"| DAP12
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    ALZHEIMER_S_DISEASE -->|"activates"| DAP12
    SYK["SYK"]
    SYK -->|"activates"| DAP12
    CD33["CD33"]
    CD33 -->|"interacts with"| DAP12
    ALZHEIMER_S_DISEASE -->|"associated with"| DAP12
    TAU["TAU"]
    TAU -->|"activates"| DAP12
    TREM2 -->|"inhibits"| DAP12
    ALZHEIMER -->|"activates"| DAP12
    AND["AND"]
    AND -->|"activates"| DAP12
    MICROGLIA -->|"associated with"| DAP12
    ALZHEIMER -->|"associated with"| DAP12
    style DAP12 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0