Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about synaptic_plasticity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| BDNF | activates | gene | 0.90 |
| calcium | regulates | protein | 0.72 |
| amyloid_beta | inhibits | protein | 0.64 |
| CaMKII_protein | promotes | protein | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Sleep Spindle-Synaptic Plasticity Enhancement | 0.491 | neurodegeneration | Sleep disruption as cause and consequenc |
Scientific analyses that reference this entity
neuroscience | 2026-04-03 | 49 hypotheses Top: 0.709
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Effects of caffeine on sleep and cognition. [PMID:21531247] | Snel J, Lorist MM | Prog Brain Res | 2011 | 1 |
| Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and [PMID:19536808] | Kunttas-Tatli E, Bose A, Kahali B, Bisho | Genesis | 2009 | 1 |
| CI-994 is a dual modulator of class I HDACs and Wnt/β-catenin signaling for the [PMID:41654970] | Lu W, Kawatani K, Ren Y | Alzheimers Res Ther | 2026 | 0 |
| Molecular brake on firing pattern transitions in MHbChAT neurons to mediate nico [PMID:41903536] | Zheng ZW, Min PX, Luo YL, Mao XF, Zhang | Neuron | 2026 | 0 |
| Presynaptic P/Q calcium channel deficit promotes postsynaptic excitability remod [PMID:41932329] | Thompson SJ, Miao QL, Sonig A, Noebels J | Neuron | 2026 | 0 |
| Estradiol modulates neuronal network hyperexcitability in select NDD risk genes. [PMID:41757108] | Pruitt A, Yang L, Lee S, Balafkan N, Sea | bioRxiv : the preprint server | 2026 | 0 |
| Vitamin D supplementation and COVID-19 risk: a population-based, cohort study. [PMID:34273098] | ["Oristrell J", "Oliva J", "Casado E", " | Journal of endocrinological in | 2022 | 0 |
| Intracellular calcium homeostasis and its dysregulation underlying epileptic sei [PMID:36403388] | Zhou X, Chen Z, Xiao L, Zhong Y, Liu Y, | Seizure | 2022 | 0 |
| Homeostatic plasticity and burst activity are mediated by hyperpolarization-acti [PMID:33547341] | Rátkai A, Tárnok K, Aouad HE, Micska B, | Scientific reports | 2021 | 0 |
| Machine learning reveals bilateral distribution of somatic L1 insertions in huma [PMID:33432196] | ["Zhu X", "Zhou B", "Pattni R", "Gleason | Nature neuroscience | 2021 | 0 |
| Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution. [PMID:34381213] | ["Su Z", "Zhang K", "Kappel K", "Li S", | Nature | 2021 | 0 |
| Prevalence and follow-up of potentially inappropriate medication and potentially [PMID:32641251] | ["van Loveren F", "van Berlo-van de Laar | Journal of geriatric oncology | 2021 | 0 |
| Neuronal Cav3 channelopathies: recent progress and perspectives. [PMID:32638069] | Lory P, Nicole S, Monteil A | Pflugers Archiv : European jou | 2020 | 0 |
| Single-cell epigenomic analyses implicate candidate causal variants at inherited [PMID:33106633] | ["Corces M", "Shcherbina A", "Kundu S", | Nature genetics | 2020 | 0 |
| Reciprocal associations between depression, anxiety and work-related injury. [PMID:31685530] | ["Gerasimaviciute V", "B\u00fcltmann U", | Injury prevention : journal of | 2020 | 0 |
| On-surface synthesis of planar dendrimers via divergent cross-coupling reaction. [PMID:31160575] | ["Li D", "Li S", "Xie Y", "Hua X", "Long | Nature communications | 2019 | 0 |
| STAT4 Directs a Protective Innate Lymphoid Cell Response to Gastrointestinal Inf [PMID:31562212] | ["Dulson S", "Watkins E", "Crossman D", | Journal of immunology (Baltimo | 2019 | 0 |
| Epidemiology of Bradykinin-mediated angioedema: a systematic investigation of ep [PMID:29728119] | ["Ayg\u00f6ren-P\u00fcrs\u00fcn E", "Mag | Orphanet journal of rare disea | 2018 | 0 |
| Predictors of Extended Length of Hospital Stay Following Surgical Repair of Cong [PMID:30171266] | ["Azhar A", "Aljefri H"] | Pediatric cardiology | 2018 | 0 |
| Interstitial lung abnormalities and self-reported health and functional status. [PMID:29317545] | ["Axelsson G", "Putman R", "Araki T", "S | Thorax | 2018 | 0 |