Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TRIM37: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive review of TRIM37 gene, a RBCC family E3 ubiquitin ligase with roles in peroxisome biogenesis, centrosome function, and mulibrey nanism
| Gene Symbol | TRIM37 |
| Full Name | Tripartite Motif Containing 37 |
| Chromosome | 17q11.2 |
| Function | is a member of the TRIM (Tripartite Motif) protein family, characterized by the presence of RING finger, B-box, and coiled-coil domains. |
| Primary Expression | Ubiquitous (brain, heart, liver, lung) |
| Molecular Weight | ~110 kDa |
| Amino Acids | 964 aa |
| UniProt ID | Q9C0B1 |
| NCBI Gene ID | 4591 |
| Ensembl ID | ENSG00000108395 |
| OMIM | 604193 |
| GeneCards | TRIM37 |
| Human Protein Atlas | TRIM37 |
| Protein Length | 964 amino acids |
| Associated Diseases | Als, Cancer, Carcinoma |
| KG Connections | 11 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
TRIM37["<b>TRIM37</b>"]
Als{"Als"}
TRIM37 -->|"associated with"| Als
Cancer{"Cancer"}
TRIM37 -->|"associated with"| Cancer
Carcinoma{"Carcinoma"}
TRIM37 -->|"associated with"| Carcinoma
NOS2["NOS2"]
TRIM37 -->|"associated with"| NOS2
neurodegeneration["neurodegeneration"]
TRIM37 -->|"implicated in"| neurodegeneration
NFKB1["NFKB1"]
NFKB1 -->|"associated with"| TRIM37
RAB7A["RAB7A"]
RAB7A -->|"associated with"| TRIM37
CTNNB1["CTNNB1"]
CTNNB1 -->|"associated with"| TRIM37
KNL1["KNL1"]
KNL1 -->|"associated with"| TRIM37
CANCER["CANCER"]
CANCER -->|"associated with"| TRIM37
HSPA8["HSPA8"]
HSPA8 -->|"associated with"| TRIM37
RPS6KA1["RPS6KA1"]
RPS6KA1 -->|"associated with"| TRIM37
style TRIM37 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||