gene

TRIM37

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRIM37: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

11Connections
0Hypotheses
0Analyses
4Outgoing
7Incoming
0Experiments

Summary

Comprehensive review of TRIM37 gene, a RBCC family E3 ubiquitin ligase with roles in peroxisome biogenesis, centrosome function, and mulibrey nanism

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🧬 Gene Info
Gene SymbolTRIM37
Full NameTripartite Motif Containing 37
Chromosome17q11.2
Functionis a member of the TRIM (Tripartite Motif) protein family, characterized by the presence of RING finger, B-box, and coiled-coil domains.
Primary ExpressionUbiquitous (brain, heart, liver, lung)
Molecular Weight~110 kDa
Amino Acids964 aa
UniProt IDQ9C0B1
NCBI Gene ID4591
Ensembl IDENSG00000108395
OMIM604193
GeneCardsTRIM37
Human Protein AtlasTRIM37
Protein Length964 amino acids
Associated DiseasesAls, Cancer, Carcinoma
KG Connections11 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: TRIM37 — AlphaFold Q9C0B1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

TRIM37 — Tripartite Motif Containing 37

gene · 1362 words

RRAGB — Ras-Related GTP Binding B

gene · 2988 words

RPS6KA1 — Ribosomal Protein S6 Kinase A1

gene · 1452 words

KNL1

gene · 503 words

Genes

index · 271 words

Pathway Diagram

graph TD
    TRIM37["<b>TRIM37</b>"]
    Als{"Als"}
    TRIM37 -->|"associated with"| Als
    Cancer{"Cancer"}
    TRIM37 -->|"associated with"| Cancer
    Carcinoma{"Carcinoma"}
    TRIM37 -->|"associated with"| Carcinoma
    NOS2["NOS2"]
    TRIM37 -->|"associated with"| NOS2
    neurodegeneration["neurodegeneration"]
    TRIM37 -->|"implicated in"| neurodegeneration
    NFKB1["NFKB1"]
    NFKB1 -->|"associated with"| TRIM37
    RAB7A["RAB7A"]
    RAB7A -->|"associated with"| TRIM37
    CTNNB1["CTNNB1"]
    CTNNB1 -->|"associated with"| TRIM37
    KNL1["KNL1"]
    KNL1 -->|"associated with"| TRIM37
    CANCER["CANCER"]
    CANCER -->|"associated with"| TRIM37
    HSPA8["HSPA8"]
    HSPA8 -->|"associated with"| TRIM37
    RPS6KA1["RPS6KA1"]
    RPS6KA1 -->|"associated with"| TRIM37
    style TRIM37 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (4)

TargetRelationTypeStr
Alsassociated_withdisease0.65
Cancerassociated_withdisease0.65
Carcinomaassociated_withdisease0.65
NOS2associated_withgene0.60

Incoming (7)

SourceRelationTypeStr
NFKB1associated_withgene0.60
RAB7Aassociated_withgene0.60
CTNNB1associated_withgene0.60
KNL1associated_withgene0.60
HSPA8associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found