gene

NOS2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NOS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

236Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

NOS2 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, activates, regulates. Associated with Aging, Als, Cancer. Connected to 124 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NOS2
Full Name	Nitric Oxide Synthase 2
Aliases	Inducible Nitric Oxide Synthase
Chromosome	17q11.2
Protein Family	Nitric oxide synthase family
Protein Type	Enzyme
Function	In the immune system, iNOS-mediated NO production serves several critical functions
Primary Expression	astrocytes, microglia, and neurons in response to injury or disease
Molecular Weight	131 kDa
Exons	26
Pathways	NF-κB
GeneCards	NOS2
Human Protein Atlas	NOS2
Associated Diseases	ALS, Alzheimer, Cancer, Carcinoma
Interactions	MMP2, PTGS2, KDR, MMP9, ICAM1, SPP1
KG Connections	236 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    NOS2["NOS2"]
    NOS2 -->|"activates"| Inflammation["Inflammation"]
    NOS2 -->|"activates"| Aging["Aging"]
    NOS2 -->|"activates"| Ms["Ms"]
    NOS2 -->|"target for"| Diabetes["Diabetes"]
    NOS2 -->|"target for"| Neurodegeneration["Neurodegeneration"]
    NOS2 -->|"regulates"| Als["Als"]
    NOS2 -->|"regulates"| P2RX3["P2RX3"]
    PANX1["PANX1"] -->|"regulates"| NOS2
    S100B["S100B"] -->|"regulates"| NOS2
    RELB["RELB"] -->|"regulates"| NOS2
    P2RY1["P2RY1"] -->|"regulates"| NOS2
    CASP3["CASP3"] -->|"regulates"| NOS2
    SOCS3["SOCS3"] -->|"regulates"| NOS2
    TRPA1["TRPA1"] -->|"regulates"| NOS2
    GENES["GENES"] -->|"regulates"| NOS2
    CXCL2["CXCL2"] -->|"regulates"| NOS2
    SNAP25["SNAP25"] -->|"regulates"| NOS2

Outgoing (128)

Target	Relation	Type	Str
Inflammation	activates	disease	0.75
IL10	activates	gene	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Neurodegeneration	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Cancer	associated_with	disease	0.65
Carcinoma	associated_with	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Ulcerative Colitis	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Aging	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Alzheimer	protects_against	disease	0.65
Cancer	protects_against	disease	0.65
Aging	protects_against	disease	0.65
ALS	protects_against	disease	0.65
P2RX3	regulates	gene	0.60
RELA	regulates	gene	0.60
SYP	regulates	gene	0.60
CHRNA7	regulates	gene	0.60
SYT1	regulates	gene	0.60
STAT3	regulates	gene	0.60
HMOX1	regulates	gene	0.60
TRPV1	regulates	gene	0.60
P2RY2	regulates	gene	0.60
FOXP3	regulates	gene	0.60
TPH2	regulates	gene	0.60
CCL3	regulates	gene	0.60
MMP2	inhibits	gene	0.60
PTGS2	inhibits	gene	0.60
KDR	inhibits	gene	0.60
MMP9	inhibits	gene	0.60
ICAM1	inhibits	gene	0.60
SPP1	inhibits	gene	0.60
CCL3	therapeutic_target	gene	0.60
ESR1	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
CIITA	therapeutic_target	gene	0.60
DLL1	therapeutic_target	gene	0.60
SERPINE1	inhibits	gene	0.60
RAGE	therapeutic_target	gene	0.60
SQSTM1	activates	gene	0.60

Incoming (108)

Source	Relation	Type	Str
Safranal	downregulates	compound	0.90
RELA	interacts_with	gene	0.65
PANX1	regulates	gene	0.60
S100B	regulates	gene	0.60
RELB	regulates	gene	0.60
P2RY1	regulates	gene	0.60
CASP3	regulates	gene	0.60
SOCS3	regulates	gene	0.60
TRPA1	regulates	gene	0.60
CXCL2	regulates	gene	0.60
SNAP25	regulates	gene	0.60
P2RX7	regulates	gene	0.60
SYT2	regulates	gene	0.60
TNF	regulates	gene	0.60
SOD2	regulates	gene	0.60
RAGE	therapeutic_target	gene	0.60
SERPINE1	inhibits	gene	0.60
BCL2	activates	gene	0.60
BAX	activates	gene	0.60
GFAP	activates	gene	0.60
TUBB3	activates	gene	0.60
NGF	activates	gene	0.60
VEGFA	activates	gene	0.60
NRF2	activates	gene	0.60
ICAM1	inhibits	gene	0.60
MMP9	inhibits	gene	0.60
PTGS2	inhibits	gene	0.60
KDR	inhibits	gene	0.60
SPP1	inhibits	gene	0.60
MMP2	inhibits	gene	0.60
NFKB1	associated_with	gene	0.60
RAB7A	associated_with	gene	0.60
CTNNB1	associated_with	gene	0.60
KNL1	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
RPS6KA1	associated_with	gene	0.60
TRIM37	associated_with	gene	0.60
ARG1	activates	gene	0.60
TNF	activates	gene	0.60
TNF	therapeutic_target	gene	0.60
ESR1	therapeutic_target	gene	0.60
IL1B	therapeutic_target	gene	0.60
IL6	associated_with	gene	0.60
ESR2	associated_with	gene	0.60
IL6	therapeutic_target	gene	0.60
PTGS2	therapeutic_target	gene	0.60
DRD2	therapeutic_target	gene	0.60
NOS3	therapeutic_target	gene	0.60
BDNF	therapeutic_target	gene	0.60
ESR2	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NOS2

Understanding Entity Pages

Summary

Wiki Pages (21)

NOS2 - Nitric Oxide Synthase 2

Microglial Cells — Cell Type Hierarchy

cGMP Signaling Pathway in Neurodegeneration

Microglia

Gasotransmitters in Neuroprotection - AD/PD

NOS1 — Nitric Oxide Synthase 1

S-Nitrosylation in Neurodegeneration

KDR Gene

HIF Signaling in Neurodegeneration

RPS6KA1 — Ribosomal Protein S6 Kinase A1

TRIM37 — Tripartite Motif Containing 37

S-Nitrosylation Modulation Therapy for Neurodegeneration

Nitric Oxide Signaling in 4R-Tauopathies

Sepiapterin Reductase (SPR)

NOSTRIN Protein

Nitric Oxide Producing Neurons

NOS2 Protein (Inducible Nitric Oxide Synthase)

Nitric Oxide Signaling in Neurodegeneration

SYT2 Gene