gene

NFKB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NFKB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

417Connections

2Hypotheses

10Analyses

50Outgoing

50Incoming

2Experiments

20Debates

Summary

NFKB1 is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, activates. Associated with ALS, Als, Alzheimer. Connected to 162 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	NF
Full Name	κB p105/p50 Protein
Aliases	NFKB1
Function	Nf Κb P105 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
GeneCards	NF
Human Protein Atlas	NF
Associated Diseases	Als, Alzheimer, Alzheimer'S Disease, Cancer, Carcinoma
Known Drugs/Compounds	Berberine, Electroacupuncture, Xiyangshen Sanqi Danshen Granules
Interactions	ALZHEIMER, ALZHEIMER DISEASE, ALZHEIMER'S DISEASE, AMPK, AMYLOID, ANG
SciDEX Hypotheses	Dual NF-κB/MMP Inhibition Strategy Inflammaging-Epigenome Decoupling Strategy
KG Connections	417 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

🔮 Predicted Structure: NFKB1 — AlphaFold P19838 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

NF-κB p105/p50 Protein

protein · 613 words

→

NFKB1 Gene

gene · 607 words

→

Pathway Diagram

graph TD
    NFKB1["NFKB1"]
    NFKB1 -->|"activates"| IL8["IL8"]
    NFKB1 -->|"regulates"| CD200R1["CD200R1"]
    NFKB1 -->|"regulates"| TNF["TNF"]
    NFKB1 -->|"regulates"| IL1B["IL1B"]
    NFKB1 -->|"regulates"| microglial_inflammation["microglial inflammation"]
    NFKB1 -->|"regulates"| inflammation["inflammation"]
    NFKB1 -->|"target for"| Cancer["Cancer"]
    NFKB1 -->|"target for"| Als["Als"]
    NFKB1 -->|"target for"| Ms["Ms"]
    NFKB1 -->|"target for"| Inflammation["Inflammation"]
    hyperoxia["hyperoxia"] -->|"activates"| NFKB1
    TNF -->|"activates"| NFKB1
    TRAF6["TRAF6"] -->|"activates"| NFKB1
    DZSM["DZSM"] -->|"regulates"| NFKB1
    BCL2["BCL2"] -->|"target for"| NFKB1
    MTOR["MTOR"] -->|"target for"| NFKB1
    PI3K["PI3K"] -->|"target for"| NFKB1
    AKT["AKT"] -->|"target for"| NFKB1
    EGFR["EGFR"] -->|"target for"| NFKB1
    INFLAMMATION["INFLAMMATION"] -->|"target for"| NFKB1

Outgoing (255)

Target	Relation	Type	Str
SASP	promotes	process	0.95
C3	activates	gene	0.95
Tnf-Α/Nf-Κb/Mapk Signaling Pathway	involved_in	pathway	0.90
Tnf-Α	upregulates	protein	0.90
Pro-Inflammatory Cytokines	upregulates	compound	0.90
NLRP3	regulates	gene	0.90
Pro-Inflammatory Pathways	activates	pathway	0.90
Neuroinflammation	upregulates	process	0.90
Pro-inflammatory Pathways	activates	pathway	0.90
Dopamine Neuron Survival	inhibits	phenotype	0.90
pro-inflammatory cytokine transcription	activates	process	0.90
Neuroinflammation	activates	process	0.90
Inflammation	causes	process	0.90
IL6	activates	gene	0.90
inflammatory activation	mediates	process	0.87
GFAP	regulates	gene	0.85
ALZHEIMER'S DISEASE	biomarker_for	disease	0.85
PARKINSON'S DISEASE	biomarker_for	disease	0.85
MMP2	upregulates	protein	0.85
MMP9	upregulates	protein	0.85
Mir125B	activates	biomarker	0.85
inflammatory response	drives	process	0.85
Neuroinflammation	promotes	process	0.85
TP53	regulates	protein	0.85
Alzheimer's Disease	activates	disease	0.80
Alzheimer'S Disease	associated_with	disease	0.80
Cognitive Protection	involved_in	process	0.80
Steroid Hormone Effects	involved_in	mechanism	0.80
Inflammation	associated_with	process	0.80
Lipid Metabolism	regulates	process	0.80
IL8	activates	gene	0.80
Cytoprotective Proteins	upregulates	process	0.80
Cytoprotection	involved_in	process	0.80
lipid metabolism dysregulation	drives	process	0.80
Alzheimer's Disease	contributes_to	disease	0.80
Cognitive Function	involved_in	phenotype	0.80
NF-kB signaling	participates_in	pathway	0.80
Als	associated_with	disease	0.75
Cancer	therapeutic_target	disease	0.75
Cognitive Impairment Protection	mediates	mechanism	0.75
microglial inflammation	regulates	process	0.70
A1 astrocytes	activates	cell_type	0.70
inflammation	regulates	process	0.70
SASP transcription	regulates	pathway	0.70
IL1B	regulates	protein	0.70
SASP inflammatory cytokines	regulates	mechanism	0.70
TNF	regulates	protein	0.70
KCNK2	interacts_with	gene	0.70
Mapk	therapeutic_target	pathway	0.70
CTNNB1	associated_with	gene	0.69

Incoming (162)

Source	Relation	Type	Str
h-immunity-6e54942b	relates_to	hypothesis	0.00
Berberine	inhibits	compound	0.95
Nfkbia	inhibits	protein	0.95
h-646ae8f1	targets	hypothesis	0.90
TGM2	drives	protein	0.90
IKBA	suppresses	protein	0.90
Electroacupuncture	inhibits	drug	0.90
HVCN1	activates	gene	0.90
MYDD88	activates	protein	0.90
ROS overproduction	activates	process	0.88
Theranekron	downregulates	drug	0.85
TLR4	activates	protein	0.85
AMPK	inhibits	protein	0.85
Tg2-In1	suppresses	drug	0.85
hyperoxia	activates	phenotype	0.80
Xiyangshen Sanqi Danshen Granules	inhibits	drug	0.80
SIRT1	inhibits	protein	0.80
APP	activates	gene	0.80
TRAF6	activates	protein	0.70
DZSM	regulates	drug	0.70
NGFR	activates	gene	0.70
TNF	activates	protein	0.70
NR1D1	represses	gene	0.70
NR1D1	associated_with	gene	0.70
HDAC3	inhibits	protein	0.70
EGFR	therapeutic_target	gene	0.70
HDAC9	inhibits	gene	0.70
CASP3	therapeutic_target	gene	0.70
PI3K	therapeutic_target	gene	0.70
NR1D1	inhibits	gene	0.70
NFE2L2	inhibits	gene	0.70
PINK1	phosphorylates	gene	0.65
LRRK2	co_discussed	gene	0.65
NF-ΚB	expressed_in	gene	0.60
FERROPTOSIS	expressed_in	gene	0.60
INS	regulates	gene	0.60
ALZHEIMER	therapeutic_target	gene	0.60
IL-1	therapeutic_target	gene	0.60
STAT3	inhibits	gene	0.60
APP	phosphorylates	gene	0.60
BACE1	phosphorylates	gene	0.60
ATF4	expressed_in	gene	0.60
JUN	expressed_in	gene	0.60
YWHAB	associated_with	gene	0.60
ITPR2	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
HGF	inhibits	gene	0.60
MTOR	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
RELA	expressed_in	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Dual NF-κB/MMP Inhibition Strategy	0.554	-	Blood-brain barrier tight junction disru
Inflammaging-Epigenome Decoupling Strategy	0.000	-	Epigenetic clocks and biological aging i

Mentioning Analyses (10)

Scientific analyses that reference this entity

Experiments (2)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Resveratrol protection against renal I/R injury in diabetic rats	validation	diabetic nephropathy	0.900	0.00	streptozotocin-induced diabeti	proposed	N/A
Resveratrol effects on HK-2 cells under hypoxia/reoxygenation	exploratory	diabetic nephropathy	0.850	0.00	HK-2 cells cultured in high gl	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (20)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning NFKB1 in their description or question text

No additional research found

NFKB1

Understanding Entity Pages

Summary

Wiki Pages (2)

NF-κB p105/p50 Protein

NFKB1 Gene

Pathway Diagram

Outgoing (255)

Incoming (162)

Targeting Hypotheses (2)

Mentioning Analyses (10)

Does Alectinib truly bind C1q directly with high affinity, or is this an experim

Blood-brain barrier tight junction disruption by neuroinflammatory cytokines

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

Can circadian interventions reverse microglial priming independent of sleep disr

Neuroinflammation and microglial priming in early Alzheimer's Disease

Senescent cell clearance as neurodegeneration therapy

Immune atlas neuroinflammation analysis in neurodegeneration

Astrocyte Reactivity Subtypes in Neurodegeneration

What are the mechanisms by which gut microbiome dysbiosis influences Parkinson's

Experiments (2)

Related Papers (0)

Debates (20)

Extended debate: Metabolic Reprogramming to Reverse Senescence

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Hypothesis debate: SASP Modulation Rather Than Cell Elimination

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Hypothesis debate: Metabolic Reprogramming to Reverse Senescence

Should PEA-PPARA endocannabinoid signaling be prioritized as a therapeutic strat

Should metabolic reprogramming via SIRT1/NAD+/PGC-1alpha axis be prioritized to

This analysis aims to elucidate the mechanisms by which gut microbiome dysbiosis

The fundamental premise remains unvalidated despite extensive mechanistic specul

The fundamental premise remains unvalidated despite extensive mechanistic specul

Related Research