gene

UBR4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about UBR4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

5Connections

0Hypotheses

0Analyses

3Outgoing

2Incoming

0Experiments

0Debates

Summary

Page for UBR4 — Ubiquitin Protein Ligase E3 Component N-Recognin 4

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🧬 Gene Info

Gene Symbol	UBR4
Full Name	Ubiquitin Protein Ligase E3 Component N-Recognin 4
Chromosome	1p36.21
Protein Type	Ligase
Function	encodes a large E3 ubiquitin ligase that plays critical roles in the N-end rule pathway and general protein quality control.
Primary Expression	Brain, Retina, Peripheral tissues
Molecular Weight	500 kDa
UniProt ID	Q6ZNA4
NCBI Gene ID	54716
GeneCards	UBR4
Human Protein Atlas	UBR4
Stress response	Turnover of damaged proteins
Signal transduction	Degradation of signaling components
Development	Temporal protein regulation
Associated Diseases	neurodegeneration
Interactions	AGING, UBIQUITIN
KG Connections	5 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: UBR4 — AlphaFold Q6ZNA4 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

UBR4 — Ubiquitin Protein Ligase E3 Component N-Recognin 4

gene · 641 words

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Pathway Diagram

flowchart TD
    UBR4(["UBR4"])
    Cancer["Cancer"]
    Aging["Aging"]
    Proteasome["Proteasome"]
    UBIQUITIN(["UBIQUITIN"])
    AGING(["AGING"])
    neurodegeneration["neurodegeneration"]

    UBR4 -->|"regulates"| Cancer
    UBR4 -->|"interacts with"| Aging
    UBR4 -->|"interacts with"| Proteasome
    UBIQUITIN -->|"interacts with"| UBR4
    AGING -->|"interacts with"| UBR4
    UBR4 -->|"implicated in"| neurodegeneration

    style UBR4 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (3)

Target	Relation	Type	Str
Cancer	regulates	disease	0.65
Aging	interacts_with	disease	0.65
Proteasome	interacts_with	pathway	0.60

Incoming (2)

Source	Relation	Type	Str
UBIQUITIN	interacts_with	gene	0.60
AGING	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning UBR4 in their description or question text

No additional research found