concept

USP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about USP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

0Analyses

19Outgoing

9Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	USP1
Key Genes/Proteins	PARP1, TAZ
Related Diseases	Parp Inhibitor Sensitivity
Related Pathways	PARP Trapping

Wiki Pages (4)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    USP1["USP1"]
    USP1 -->|"interacts"| PARP1["PARP1"]
    USP1 -->|"regulates"| PARP1_Chromatin_Trapping["PARP1 Chromatin Trapping"]
    USP1 -->|"regulates"| PARP_Trapping["PARP Trapping"]
    USP1 -->|"modulates"| PARylation_Activity["PARylation Activity"]
    USP1 -->|"regulates"| Parp1_Chromatin_Trapping["Parp1 Chromatin Trapping"]
    PARP1 -->|"substrate_of"| USP1

Outgoing (19)

Target	Relation	Type	Str
PARP1	interacts_with	entity	0.95
PARP1	regulates	entity	0.95
K63-linked polyubiquitination	inhibits	process	0.91
PARP1	binds	protein	0.90
PARP1	degrades	protein	0.90
PARP Trapping	regulates	mechanism	0.90
PARylation Activity	modulates	process	0.90
Parp1 Chromatin Trapping	regulates	process	0.90
Parylation	regulates	process	0.90
TAZ	associated_with	gene	0.90
PARP1	deubiquitinates	gene	0.90
PARP1	associated_with	gene	0.90
OVARIAN CANCER	therapeutic_target	entity	0.85
Parp Inhibitor Sensitivity	regulates	phenotype	0.85
PARP1 PARylation	regulates	process	0.80
replicative stress	regulates	process	0.80
FOXO1	interacts_with	gene	0.80
cell death	promotes	process	0.75
ubiquitin-proteasome	participates_in	pathway	0.60

Incoming (9)

Source	Relation	Type	Str
PARP1	deubiquitinates	protein	0.90
DDX1	upregulates	protein	0.85
PARP1	regulates	gene	0.60
PARP1	targets	gene	0.60
DNA	activates	gene	0.60
PARP1	activates	gene	0.60
PARP1	interacts_with	gene	0.60
DDX1	activates	gene	0.60
PRMT1	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

USP1

Understanding Entity Pages

Wiki Pages (4)

Longevity and Rejuvenation Therapies Landscape

FANCF Gene