Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VAMP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
VAMP3 (Cellubrevin) - SNARE protein essential for synaptic vesicle trafficking, endosomal recycling, and neurotransmitter release in the central nervous system
| Gene Symbol | VAMP3 |
| Full Name | Vesicle Associated Membrane Protein 3 |
| Aliases | Cellubrevin |
| Chromosome | 1p36.22 |
| Function | is a small membrane protein with a simple structural organization |
| Primary Expression | neurons, neuroendocrine cells, and various non-neuronal tissues, where it participates in diverse trafficking pathways including synaptic vesicle exoc |
| Molecular Weight | ~12 kDa |
| Amino Acids | 116 aa |
| Exons | 6 |
| UniProt ID | Q15886 |
| NCBI Gene ID | 9515 |
| Ensembl ID | ENSG00000143842 |
| OMIM | 606280 |
| GeneCards | VAMP3 |
| Human Protein Atlas | VAMP3 |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["VAMP3"]
N1["Als"]
N0 -->|"contributes to"| N1
N2["ALS"]
N0 -->|"contributes to"| N2
N3["SGMS1"]
N0 -->|"associated with"| N3
N4["Stem Cell"]
N0 -->|"contributes to"| N4
N5["Neuron"]
N0 -->|"contributes to"| N5
N6["AND"]
N0 -->|"associated with"| N6
N7["GENES"]
N0 -->|"associated with"| N7
N8["Rb"]
N0 -->|"associated with"| N8
N3 -->|"associated with"| N0
N0 -->|"expressed in"| N4
N0 -->|"expressed in"| N5
N9["Genes"]
N0 -->|"associated with"| N9
N10["DUSP2"]
N10 -->|"co discussed"| N0
N7 -->|"regulates"| N0
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 disease
class N3 gene
class N6 gene
class N7 gene
class N8 protein
class N10 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Als | contributes_to | disease | 0.65 |
| ALS | contributes_to | disease | 0.65 |
| SGMS1 | associated_with | gene | 0.60 |
| Rb | associated_with | protein | 0.60 |
| Stem Cell | contributes_to | cell_type | 0.60 |
| Neuron | contributes_to | cell_type | 0.60 |
| AND | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| Stem Cell | expressed_in | cell_type | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SGMS1 | associated_with | gene | 0.60 |
| DUSP2 | co_discussed | gene | 0.50 |
| microcephaly | associated_with | disease | 0.50 |
| GENES | regulates | gene | 0.50 |
| NEURON | co_discussed | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||