gene

VAMP3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VAMP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

15Connections
0Hypotheses
0Analyses
10Outgoing
5Incoming

Summary

VAMP3 (Cellubrevin) - SNARE protein essential for synaptic vesicle trafficking, endosomal recycling, and neurotransmitter release in the central nervous system

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🧬 Gene Info
Gene SymbolVAMP3
Full NameVesicle Associated Membrane Protein 3
AliasesCellubrevin
Chromosome1p36.22
Functionis a small membrane protein with a simple structural organization
Primary Expressionneurons, neuroendocrine cells, and various non-neuronal tissues, where it participates in diverse trafficking pathways including synaptic vesicle exoc
Molecular Weight~12 kDa
Amino Acids116 aa
Exons6
UniProt IDQ15886
NCBI Gene ID9515
Ensembl IDENSG00000143842
OMIM606280
GeneCardsVAMP3
Human Protein AtlasVAMP3
Associated DiseasesAlzheimer's disease, Parkinson's disease
KG Connections15 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: VAMP3 — AlphaFold Q15886 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

VAMP3 Gene

gene · 1682 words

Exosome Biogenesis in Neurodegeneration

mechanism · 3104 words

Mitochondria-Lysosome Contact Site (MLCS) Dysfunction Hypothesis in Parkinson's Disease

hypothesis · 2796 words

STX2 — Syntaxin 2

gene · 2774 words

STX12 - Syntaxin 12

gene · 2493 words

Synaptic Vesicle Cycle

cell_type · 2471 words

Pathway Diagram

flowchart TD
    N0["VAMP3"]
    N1["Als"]
    N0 -->|"contributes to"| N1
    N2["ALS"]
    N0 -->|"contributes to"| N2
    N3["SGMS1"]
    N0 -->|"associated with"| N3
    N4["Stem Cell"]
    N0 -->|"contributes to"| N4
    N5["Neuron"]
    N0 -->|"contributes to"| N5
    N6["AND"]
    N0 -->|"associated with"| N6
    N7["GENES"]
    N0 -->|"associated with"| N7
    N8["Rb"]
    N0 -->|"associated with"| N8
    N3 -->|"associated with"| N0
    N0 -->|"expressed in"| N4
    N0 -->|"expressed in"| N5
    N9["Genes"]
    N0 -->|"associated with"| N9
    N10["DUSP2"]
    N10 -->|"co discussed"| N0
    N7 -->|"regulates"| N0

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 disease
    class N3 gene
    class N6 gene
    class N7 gene
    class N8 protein
    class N10 gene

Outgoing (10)

TargetRelationTypeStr
Alscontributes_todisease0.65
ALScontributes_todisease0.65
SGMS1associated_withgene0.60
Rbassociated_withprotein0.60
Stem Cellcontributes_tocell_type0.60

Incoming (5)

SourceRelationTypeStr
SGMS1associated_withgene0.60
DUSP2co_discussedgene0.50
microcephalyassociated_withdisease0.50
GENESregulatesgene0.50
NEURONco_discussedgene0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found