concept

SGMS1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about SGMS1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

206Connections

1Hypotheses

2Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	SGMS1
Key Genes/Proteins	BACE1
Related Diseases	Alzheimer Disease
Related Pathways	Cholesterol Metabolism, lipid metabolism
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    SGMS1["SGMS1"]
    style SGMS1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    SGMS1 -->|"catalyzes"| Sphingomyelin["Sphingomyelin"]
    SGMS1 -->|"involved_in"| Sphingomyelin_Biosynthesis["Sphingomyelin Biosynthesis"]
    SGMS1 -->|"modulates"| BACE1([BACE1])
    SGMS1 -->|"involved_in"| Intracellular_Vesicular_Transp["Intracellular Vesicular Transport"]
    SGMS1 -->|"involved_in"| Cholesterol_Metabolism["Cholesterol Metabolism"]
    SGMS1 -->|"contributes to"| Neuroinflammation["Neuroinflammation"]
    SGMS1 -->|"involved_in"| Cell_Proliferation["Cell Proliferation"]
    SGMS1 -->|"involved_in"| Apoptosis["Apoptosis"]
    SGMS1 -->|"interacts"| SGMS2([SGMS2])
    SGMS1 -->|"studied_in"| neurodegeneration["neurodegeneration"]
    AMYLOID__(["AMYLOID Beta"]) -.->|"downregulates"| SGMS1
    h_fdb07848["h-fdb07848"] -->|"targets"| SGMS1
    FTY720{"FTY720"} -->|"upregulates"| SGMS1
    SGMS2 -->|"interacts"| SGMS1
    ABP([ABP]) -->|"regulates"| SGMS1

Outgoing (133)

Target	Relation	Type	Str
Sphingomyelin	catalyzes	compound	0.95
BACE1	modulates	protein	0.90
Intracellular Vesicular Transport	involved_in	process	0.90
Amyloid Plaques	associated_with	biomarker	0.88
Alzheimer Disease	associated_with	disease	0.88
Cholesterol Metabolism	involved_in	pathway	0.88
Cell Proliferation	involved_in	process	0.85
Neuroinflammation	contributes_to	process	0.85
Apoptosis	involved_in	process	0.85
oligodendrocytes	associated_with	cell_type	0.80
oligodendrocytes	regulates	cell_type	0.80
lipid metabolism	participates_in	pathway	0.80
oligodendrocytes	implicated_in	cell_type	0.80
SGMS2	regulates	gene	0.70
oligodendrocytes	expressed_in	cell_type	0.70
apoptosis pathway	participates_in	pathway	0.70
neural stem cells	associated_with	cell_type	0.70
Alzheimer	activates	disease	0.65
Als	inhibits	disease	0.65
Ischemia	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Stroke	expressed_in	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	contributes_to	disease	0.65
Als	associated_with	disease	0.65
ALS	inhibits	disease	0.65
ALS	expressed_in	disease	0.65
ALS	contributes_to	disease	0.65
ALS	associated_with	disease	0.65
Als	encodes	disease	0.65
neurodegeneration	associated_with	disease	0.61
SGMS2	interacts_with	gene	0.61
SGMS2	co_mentioned_with	gene	0.60
neurodegeneration	implicated_in	disease	0.60
sphingomyelin	involved_in	pathway	0.60
amyloid-beta peptide generation	associated_with	pathway	0.60
membrane transport	involved_in	pathway	0.60
brain	expressed_in	cell_type	0.60
hearing impairment	causes	disease	0.60
BACE1	regulates	protein	0.60
neuronal differentiation	involved_in	pathway	0.60
neurodevelopmental disorders	implicated_in	disease	0.60
circular RNA	involved_in	pathway	0.60
SGMS2	expressed_in	gene	0.60
CERS2	activates	gene	0.60
SGMS2	inhibits	gene	0.60
SGMS2	contributes_to	gene	0.60
VAMP3	associated_with	gene	0.60
APP	expressed_in	gene	0.60
Rb	associated_with	protein	0.60

Incoming (73)

Source	Relation	Type	Str
h-fdb07848	targets_gene	hypothesis	0.90
h-fdb07848	targets	hypothesis	0.80
SGMS2	interacts_with	gene	0.61
ABP	regulates	gene	0.60
SGMS2	expressed_in	gene	0.60
SGMS2	inhibits	gene	0.60
CERS6	activates	gene	0.60
ASAH1	activates	gene	0.60
CERS2	activates	gene	0.60
SGMS2	contributes_to	gene	0.60
ASAH1	contributes_to	gene	0.60
APP	expressed_in	gene	0.60
VAMP3	associated_with	gene	0.60
ASAH1	regulates	gene	0.60
fingolimod	associated_with	compound	0.60
CRLS1	activates	gene	0.60
RNF20	activates	gene	0.60
APOPTOSIS	contributes_to	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
STROKE	expressed_in	gene	0.60
APOPTOSIS	expressed_in	gene	0.60
AMYLOID	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
AMYLOID-BETA	expressed_in	gene	0.60
APOPTOSIS	regulates	gene	0.60
GENES	contributes_to	gene	0.60
GENES	activates	gene	0.60
GENES	expressed_in	gene	0.60
AND	associated_with	gene	0.60
RNA	expressed_in	gene	0.60
RNA	associated_with	gene	0.60
MIRNAS	interacts_with	gene	0.60
RNA	interacts_with	gene	0.60
RAS	associated_with	gene	0.60
RNA	modulates	gene	0.60
PIKFYVE	activates	gene	0.60
LXR	expressed_in	gene	0.55
microcephaly	associated_with	disease	0.50
apoptosis	associated_with	process	0.50
CELL PROLIFERATION	associated_with	concept	0.50
CERAMIDE	inhibits	concept	0.50
Hippocampus	inhibits	entity	0.50
asah1	regulates	gene	0.50
Sphingolipid	regulates	pathway	0.50
Hippocampus	expressed_in	entity	0.50
CEREBELLUM	expressed_in	concept	0.50
apoptosis	regulates	process	0.50
LIPID METABOLISM	regulates	pathway	0.50
CERAMIDE	associated_with	concept	0.50

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SGMS1-Driven Sphingomyelin Accumulation Impairs BACE1 Lysoso	0.542	neurodegeneration	What molecular mechanisms link elevated

Mentioning Analyses (2)

Scientific analyses that reference this entity

What molecular mechanisms link elevated sphingomyelin synthase activity to incre

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.542

Lipid raft composition changes in synaptic neurodegeneration

neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.648

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

SGMS1

Understanding Entity Pages

Wiki Pages (20)

Sphingolipid Metabolism in Neurodegeneration

Ceramide Signaling Pathway in Neurodegeneration

Sphingolipid Signaling Pathway in Neurodegeneration

ANG — Angiogenin

ANG Protein

Parkin Activators for Parkinson's Disease

PINK1 Activators for Parkinson's Disease

Sphingolipid Metabolism Dysregulation in 4R-Tauopathies

Sphingolipid Metabolism in Neurodegeneration

Microcephaly

Companies

SYNA — Synapsin I

ampk-activators

PINK1-Parkin Mitophagy Activators

nrf2-activators-parkinsons-disease

NRF2 Activators in Neurodegenerative Disease

Ceramide Signaling Pathway

Ephrin Signaling Modulation Therapy

PINK1/Parkin Activators

BACE1 (Redirect)