Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about VGAT: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SLC32A1 |
| Chromosome | 20q11.23 |
| Protein Family | Major facilitator superfamily (MFS) |
| Protein Type | Location |
| Function | SLC32A1 encodes the vesicular GABA transporter (VGAT), also known as the vesicular inhibitory amino acid transporter (VIAAT). |
| Pathways | autophagy pathway, Apoptosis, Necroptosis, Pyroptosis |
| Ensembl ID | ENSG00000103838 |
| GeneCards | SLC32A1 |
| Human Protein Atlas | SLC32A1 |
| Protein Size | 525 amino acids |
| Topology | 10 transmembrane domains |
| GABA | 0.2-0.5 mM |
| Glycine | 0.5-1.0 mM |
| Beta-alanine | 2-5 mM |
| Taurine | 5-10 mM |
| Associated Diseases | ALS, Cancer, Tumor |
| Interactions | SNAP25, SST, GRIA2, NPY, PVALB, SLC17A6 |
| KG Connections | 102 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
VGAT(["VGAT"])
GABAergic_signaling["GABAergic signaling"]
VACHT(["VACHT"])
Hippocampus["Hippocampus"]
GLUTAMATE("GLUTAMATE")
acetylcholine["acetylcholine"]
VGLUT1(["VGLUT1"])
GABA(["GABA"])
VGAT -->|"regulates"| GABAergic_signaling
VGAT -.->|"inhibits"| VACHT
VGAT -.->|"inhibits"| Hippocampus
VGAT -.->|"inhibits"| GLUTAMATE
acetylcholine -.->|"inhibits"| VGAT
VGLUT1 -.->|"inhibits"| VGAT
GABA -.->|"inhibits"| VGAT
style VGAT fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| GABAergic signaling | regulates | pathway | 0.70 |
| VACHT | inhibits | protein | 0.50 |
| Hippocampus | inhibits | entity | 0.50 |
| GLUTAMATE | inhibits | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| acetylcholine | inhibits | disease | 0.50 |
| VGLUT1 | inhibits | gene | 0.50 |
| GABA | inhibits | gene | 0.50 |
| ESR1 | co_expressed_with | gene | 0.50 |
| GABA | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||