entity

Hippocampus

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Hippocampus: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1883Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

→

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Parkinson's Disease

disease · 8807 words

→

Sleep and Circadian Dysfunction in Alzheimer's Disease

mechanism · 8066 words

→

Pathway Diagram

graph TD
    Hippocampus["Hippocampus"]
    Memory["Memory Formation"]
    Cortisol["Cortisol"]
    Alzheimers["Alzheimer's Disease"]
    Amyloid["Amyloid Pathology"]
    Microglia["Microglial Activation"]
    Neuroinflammation["Neuroinflammation"]
    Complement["Complement System"]
    C1QA["C1QA"]
    SPP1["SPP1"]
    GRN["Granulin"]
    CTSB["Cathepsin B"]
    NF_kB["NF-kappaB Signaling"]
    HCN1["HCN1 Channels"]
    Phagocytosis["Phagocytosis"]
    Neurotoxicity["Neurotoxicity"]
    miR_137["miR-137-3p"]

    Hippocampus -->|"enables"| Memory
    Cortisol -->|"modulates"| Hippocampus
    Alzheimers -->|"affects"| Hippocampus
    Amyloid -->|"accumulates in"| Hippocampus
    Amyloid -->|"activates"| Microglia
    Microglia -->|"triggers"| Neuroinflammation
    Neuroinflammation -->|"activates"| Complement
    Complement -->|"expresses"| C1QA
    C1QA -->|"promotes"| Phagocytosis
    SPP1 -->|"regulates"| Microglia
    GRN -->|"modulates"| Neuroinflammation
    CTSB -->|"degrades"| Amyloid
    Neuroinflammation -->|"activates"| NF_kB
    NF_kB -->|"promotes"| Neurotoxicity
    HCN1 -->|"regulates"| Hippocampus
    miR_137 -->|"expressed in"| Hippocampus
    Neurotoxicity -->|"damages"| Hippocampus

    style Hippocampus fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style Memory fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style CTSB fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style GRN fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style Phagocytosis fill:#1b5e20,stroke:#4caf50,stroke-width:2px
    style Alzheimers fill:#7d4200,stroke:#ff9800,stroke-width:2px
    style Amyloid fill:#ef5350,stroke:#f44336,stroke-width:2px
    style Neuroinflammation fill:#ef5350,stroke:#f44336,stroke-width:2px
    style Neurotoxicity fill:#ef5350,stroke:#f44336,stroke-width:2px
    style HCN1 fill:#4a1a6b,stroke:#ba68c8,stroke-width:2px
    style SPP1 fill:#4a1a6b,stroke:#ba68c8,stroke-width:2px
    style miR_137 fill:#4a1a6b,stroke:#ba68c8,stroke-width:2px
    style NF_kB fill:#4a1a6b,stroke:#ba68c8,stroke-width:2px

Outgoing (570)

Target	Relation	Type	Str
Post-Stroke Depression	correlates_with	disease	0.85
Memory	activates	entity	0.70
NEURONS	activates	concept	0.50
TEMPORAL LOBE	associated_with	concept	0.50
ALZHEIMER'S	inhibits	concept	0.50
White Matter	inhibits	process	0.50
PREFRONTAL CORTEX	associated_with	concept	0.50
ALZHEIMER'S	activates	concept	0.50
HYPOTHALAMUS	associated_with	concept	0.50
GENE EXPRESSION	expressed_in	concept	0.50
ENTORHINAL CORTEX	expressed_in	concept	0.50
AMYLOID-β	inhibits	concept	0.50
DOPAMINE	activates	concept	0.50
SEROTONIN	activates	concept	0.50
DOPAMINE	associated_with	concept	0.50
SEROTONIN	associated_with	concept	0.50
GLUTAMATE	activates	concept	0.50
EXCITOTOXICITY	activates	concept	0.50
DENDRITIC SPINE	inhibits	concept	0.50
Cognitive Impairment	inhibits	phenotype	0.50
ALZHEIMER'S	expressed_in	concept	0.50
NUCLEUS	expressed_in	concept	0.50
Substantia Nigra	associated_with	entity	0.50
GENE EXPRESSION	activates	concept	0.50
DENDRITIC SPINE	activates	concept	0.50
NEURONS	associated_with	concept	0.50
cGAS-STING pathway	activates	pathway	0.50
FRONTAL	activates	concept	0.50
AMYGDALA	activates	concept	0.50
ALZHEIMER'S	interacts_with	concept	0.50
GENE EXPRESSION	interacts_with	concept	0.50
GENE EXPRESSION	regulates	concept	0.50
ENDOTHELIAL	activates	concept	0.50
ENDOTHELIAL CELLS	activates	concept	0.50
Proteins	expressed_in	protein	0.50
PREFRONTAL CORTEX	interacts_with	concept	0.50
White Matter	associated_with	process	0.50
CEREBRAL CORTEX	associated_with	concept	0.50
Cognitive Impairment	activates	phenotype	0.50
GLUTAMATE	inhibits	concept	0.50
Sphingolipid	associated_with	pathway	0.50
SGMS1	inhibits	concept	0.50
CEREBELLUM	expressed_in	concept	0.50
SGMS1	expressed_in	concept	0.50
Proteins	activates	protein	0.50
CEREBRAL CORTEX	activates	concept	0.50
ALZHEIMER'S	regulates	concept	0.50
AUTOPHAGOSOME	inhibits	concept	0.50
CEREBRAL CORTEX	inhibits	concept	0.50
STRIATUM	interacts_with	concept	0.50

Incoming (1313)

Source	Relation	Type	Str
Neurodegeneration-Related Gene Expression	expressed_in	process	0.90
PVB	expressed_in	gene	0.90
Cortisol	modulates	compound	0.85
MCH	expressed_in	protein	0.85
LARS2	expressed_in	gene	0.85
Neuronal Cholesterol Accumulation	expressed_in	phenotype	0.85
Gabaergic Interneurons	expressed_in	cell_type	0.85
Cadmium	causes	compound	0.85
1-Bromopropane	targets	compound	0.85
TDP-43 Pathology	expressed_in	phenotype	0.82
Haloperidol	causes	drug	0.80
miR-137-3p	expressed_in	biomarker	0.80
5-Hydroxymethylcytosine	expressed_in	compound	0.80
Long-Term Potentiation	expressed_in	process	0.80
CTF-η	expressed_in	protein	0.80
SLC17A7	expressed_in	gene	0.60
HCN1	expressed_in	gene	0.55
EPILEPSY	expressed_in	gene	0.55
PHAGOCYTOSIS	expressed_in	gene	0.55
COMPLEMENT	expressed_in	gene	0.55
AMYLOID	expressed_in	gene	0.55
ALZHEIMER'S DISEASE	expressed_in	gene	0.55
SPP1	expressed_in	gene	0.55
MICROGLIA	expressed_in	gene	0.55
ALZHEIMER	expressed_in	gene	0.55
NEURODEGENERATIVE DISEASES	expressed_in	gene	0.55
CTSB	expressed_in	gene	0.55
GRN	expressed_in	gene	0.55
C1QA	expressed_in	gene	0.55
DEMENTIA	expressed_in	gene	0.55
NF-ΚB	expressed_in	gene	0.55
C1Q	expressed_in	gene	0.55
ANXIETY	expressed_in	gene	0.55
GENES	expressed_in	gene	0.55
NEUROTOXICITY	expressed_in	gene	0.55
NEUROINFLAMMATION	expressed_in	gene	0.55
NEURODEGENERATIVE DISORDERS	expressed_in	gene	0.55
BLOOD-BRAIN BARRIER DYSFUNCTION	expressed_in	gene	0.55
APOE4	expressed_in	gene	0.55
TAU PATHOLOGY	expressed_in	gene	0.55
PERICYTE	expressed_in	gene	0.55
TAU	expressed_in	gene	0.55
HUNTINGTON	expressed_in	gene	0.55
SYNAPSE	expressed_in	gene	0.55
INFLAMMATION	expressed_in	gene	0.55
TREM2	expressed_in	gene	0.55
ERBB4	expressed_in	gene	0.55
NRG1	expressed_in	gene	0.55
SYN3	expressed_in	gene	0.55
DEPRESSION	expressed_in	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Hippocampus

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

Parthanatos in Neurodegeneration

Alpha-Synuclein Pathology

nhp-validation-animal-model

nimodipine-als

Neuroresilience Mechanisms and Evidence

NPM1 Gene

GRIA3 Gene

NRF2 Oxidative Stress Pathway

Alzheimer's Disease

nct07165106

Microglial Cells — Cell Type Hierarchy

NTF4 Protein

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison