gene

VGLUT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VGLUT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

197Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

The SLC17A7 (VGLUT1) gene encodes vesicular glutamate transporter 1, essential for excitatory neurotransmission in the cerebral cortex and hippocampus. This page covers its role in synaptic function, expression patterns, and implications for neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and epilepsy.

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🧬 Gene Info

Gene Symbol	VGLUT1
Aliases	Vesicular Glutamate Transporter 1
Chromosome	19q13.33
Primary Expression	glutamatergic (excitatory) neurons
Molecular Weight	62 kDa
Amino Acids	560 aa
Exons	12
Pathways	Amyloid, Apoptosis
Ensembl ID	ENSG00000177656
GeneCards	VGLUT1
Human Protein Atlas	VGLUT1
Associated Diseases	ISCHEMIA, epilepsy, neurodegeneration
Interactions	TAU, APOE, APOE4, VEGF, GFAP, SLC17A6
KG Connections	197 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    VGLUT1["<b>VGLUT1</b>"]
    Ms{"Ms"}
    VGLUT1 -->|"activates"| Ms
    LAMP1["LAMP1"]
    VGLUT1 -->|"associated with"| LAMP1
    Apoptosis(["Apoptosis"])
    VGLUT1 -->|"activates"| Apoptosis
    Phagocytosis(["Phagocytosis"])
    VGLUT1 -->|"activates"| Phagocytosis
    neurodegeneration["neurodegeneration"]
    VGLUT1 -->|"implicated in"| neurodegeneration
    style VGLUT1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (135)

Target	Relation	Type	Str
SLC17A7	encoded_by	gene	0.99
SYNAPTIC_VESICLE	localized_to	structure	0.95
V-ATPASE	depends_on	protein	0.85
TRORILUZOLE	pharmacological_target	drug	0.70
Ms	activates	disease	0.65
Alzheimer	activates	disease	0.65
Neurodegeneration	activates	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Als	inhibits	disease	0.65
Ischemia	activates	disease	0.65
Epilepsy	inhibits	disease	0.65
Alzheimer	regulates	disease	0.65
Diabetes	inhibits	disease	0.65
Aging	activates	disease	0.65
Epilepsy	expressed_in	disease	0.65
Multiple Sclerosis	activates	disease	0.65
ALS	regulates	disease	0.65
Autoimmune	regulates	disease	0.65
ALS	inhibits	disease	0.65
LAMP1	associated_with	gene	0.60
TAU	activates	gene	0.60
APOE	activates	gene	0.60
APOE4	activates	gene	0.60
VEGF	activates	gene	0.60
GFAP	activates	gene	0.60
VGLUT2	associated_with	gene	0.60
APP	regulates	gene	0.60
MAPT	regulates	gene	0.60
BACE1	regulates	gene	0.60
VGLUT2	expressed_in	gene	0.60
SLC17A6	activates	gene	0.60
Synaptic Vesicle	activates	pathway	0.60
Synaptic Vesicle	expressed_in	pathway	0.60
Insulin Receptor	inhibits	protein	0.60
KDM6B	activates	gene	0.60
Nmda Receptor	transports	protein	0.60
epilepsy	activates	disease	0.60
neurodegeneration	activates	disease	0.60
epilepsy	associated_with	disease	0.60
neurodegeneration	associated_with	disease	0.60
VGLUT2	regulates	gene	0.60
Apoptosis	activates	pathway	0.60
Phagocytosis	activates	pathway	0.60
APOE3	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
Endothelial	activates	cell_type	0.60
ALZHEIMER	biomarker_for	gene	0.60
GABA	biomarker_for	gene	0.60
EPILEPSY	inhibits	gene	0.60
ALZHEIMER	regulates	gene	0.60

Incoming (62)

Source	Relation	Type	Str
SLC17A7	activates	gene	0.60
KDM6B	activates	gene	0.60
SLC17A6	activates	gene	0.60
PSD95	regulates	gene	0.60
APOE	activates	gene	0.60
APOE4	activates	gene	0.60
VEGF	activates	gene	0.60
VGLUT2	associated_with	gene	0.60
APP	regulates	gene	0.60
MAPT	regulates	gene	0.60
BACE1	regulates	gene	0.60
SYNAPTOPHYSIN	activates	gene	0.60
VGLUT2	expressed_in	gene	0.60
SYNAPTOPHYSIN	expressed_in	gene	0.60
GFAP	activates	gene	0.60
TAU	activates	gene	0.60
SLC17A7	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
MMP9	expressed_in	gene	0.60
APOER2	activates	gene	0.60
AMYLOID	regulates	gene	0.60
SYNAPSE	activates	gene	0.60
AXON	regulates	gene	0.60
AND	regulates	gene	0.60
MYELIN	regulates	gene	0.60
NEURODEGENERATION	activates	gene	0.60
ALZHEIMER	biomarker_for	gene	0.60
GABA	biomarker_for	gene	0.60
AND	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	biomarker_for	gene	0.60
AMYLOID	biomarker_for	gene	0.60
EPILEPSY	inhibits	gene	0.60
AND	inhibits	gene	0.60
INSULIN RESISTANCE	associated_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
PRESENILIN	regulates	gene	0.60
AND	activates	gene	0.60
APOPTOSIS	regulates	gene	0.60
NEURON	activates	gene	0.60
EPILEPSY	expressed_in	gene	0.60
COMPLEMENT	expressed_in	gene	0.60
AND	expressed_in	gene	0.60
ALZHEIMER	activates	gene	0.60
APOE3	activates	gene	0.60
synaptic plasticity	activates	process	0.60
MAP	inhibits	gene	0.60
SLC17A7	co_mentioned	gene	0.55
excitotoxicity	inhibits	process	0.55
SLC17A7	regulates	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

VGLUT1

Understanding Entity Pages

Summary

Wiki Pages (21)

vglut1

Claustrum Neurons

Climbing Fiber Inputs

visual-cortex-layer-2-3-neurons

Synaptic Vesicle Cycle

Synaptic Vesicle Trafficking

Pathway Diagram

Outgoing (135)

Incoming (62)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Related Papers (0)

VGLUT1

Understanding Entity Pages

Summary

Wiki Pages (21)

vglut1

Claustrum Neurons

Climbing Fiber Inputs

visual-cortex-layer-2-3-neurons

Synaptic Vesicle Cycle

Synaptic Vesicle Trafficking

Cerebellar Parallel Fibers

VGLUT2 Gene

SLC17A6 Gene

mossy-cells-dentate-gyrus

Glutamate Excitotoxicity Pathway in Neurodegeneration

Synaptic Dysfunction Comparison in Neurodegenerative Diseases

synaptic-vesicle-cycling-neurodegeneration

Dorsolateral Prefrontal Cortex (DLPFC) Pyramidal Neurons

Synaptic Vesicle Cycle in Neurodegeneration

Synaptic Transmission

peripeduncular-nucleus

Anterior Cingulate Cortex (ACC) Pyramidal Neurons

MSA Neurotransmitter Dysfunction

Precuneus Cortical Neurons

Interstitial Nucleus of Cajal

Pathway Diagram

Outgoing (135)

Incoming (62)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Related Papers (0)