ESR1

Understanding Entity Pages

This page aggregates everything SciDEX knows about ESR1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

ESR1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, regulates. Associated with ALS, Aging, Als. Connected to 361 entities in the SciDEX knowledge graph.

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flowchart TD
    ESR1["ESR1<br/>(Estrogen Receptor alpha)"]
    
    %% Neurodegeneration pathways
    ESR1 --|"regulates"|--> Neurodegeneration["Neurodegeneration"]
    ESR1 --|"associated_with"|--> PD["Parkinson's Disease"]
    ESR1 --|"associated_with"|--> MS["Multiple Sclerosis"]
    ESR1 --|"activates"|--> ALS["Amyotrophic Lateral<br/>Sclerosis"]
    
    %% Key protein interactions
    ESR1 --|"associated_with"|--> APP["APP<br/>(Amyloid Precursor<br/>Protein)"]
    ESR1 --|"associated_with"|--> PSEN1["PSEN1<br/>(Presenilin 1)"]
    ESR1 --|"associated_with"|--> MAP1LC3B["MAP1LC3B<br/>(Autophagy Marker)"]
    ESR1 --|"associated_with"|--> UVRAG["UVRAG<br/>(Autophagy Regulator)"]
    
    %% Cellular pathways
    ESR1 --|"activates"|--> ImmuneResp["Immune Response<br/>Pathway"]
    ESR1 --|"activates"|--> ERStress["ER Stress<br/>Pathway"]
    
    %% Related receptors
    ESR1 --|"expressed_in"|--> ESR2["ESR2<br/>(Estrogen Receptor beta)"]
    ESR1 --|"expressed_in"|--> TNF["TNF<br/>(Tumor Necrosis Factor)"]
    
    %% Therapeutic implications
    ESR1 --|"therapeutic_target"|--> ALSTherapy["ALS Therapy"]
    ESR1 --|"therapeutic_target"|--> MSTherapy["MS Therapy"]
    
    %% Vascular connections
    ESR1 --|"regulates"|--> Cardiovascular["Cardiovascular<br/>Function"]
    ESR1 --|"associated_with"|--> Ischemia["Cerebral Ischemia"]
    
    %% Styling
    style ESR1 fill:#006494
    style ImmuneResp fill:#1b5e20
    style ALSTherapy fill:#1b5e20
    style MSTherapy fill:#1b5e20
    style Cardiovascular fill:#1b5e20
    style Neurodegeneration fill:#ef5350
    style PD fill:#ef5350
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style ERStress fill:#ef5350
    style Ischemia fill:#ef5350
    style APP fill:#4a1a6b
    style PSEN1 fill:#4a1a6b
    style MAP1LC3B fill:#4a1a6b
    style UVRAG fill:#4a1a6b
    style ESR2 fill:#4a1a6b
    style TNF fill:#4a1a6b