Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about WNT_signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| inhibitory_neurons | affects | cell_type | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PPARGC1A | inhibits | gene | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Inhibitory Neuron-Selective WNT Signaling Restoration | 0.390 | neurodegeneration | Which cell types show the most significa |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-03 | 7 hypotheses Top: 0.529
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| The Wnt3a/β-catenin/TCF7L2 signaling axis reduces the sensitivity of HER2-positi [PMID:32248976] | Shen G, Gao Q, Liu F, Zhang Y, Dai M et | Biochem Biophys Res Commun | 2020 | 0 |
| WNT signalling in the normal human adult testis and in male germ cell neoplasms. [PMID:32667987] | Young JC, Kerr G, Micati D, Nielsen JE, | Hum Reprod | 2020 | 0 |
| Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-cat [PMID:28811361] | Emons G, Spitzner M, Reineke S, Möller J | Mol Cancer Res | 2017 | 0 |
| Wnt-dependent T-cell factor-4 controls human etravillous trophoblast motility. [PMID:24605829] | Meinhardt G, Haider S, Haslinger P, Proe | Endocrinology | 2014 | 0 |
| Flt3 tandem duplication mutations cooperate with Wnt signaling in leukemic signa [PMID:15650056] | Tickenbrock L, Schwäble J, Wiedehage M, | Blood | 2005 | 0 |