RAC1

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

RAC1 is a Rho GTPase regulating actin cytoskeleton, synaptic plasticity, mitochondrial dynamics, and neuroinflammation in neurodegenerative diseases including Alzheimer's and Parkinson's

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flowchart TD
    RAC1["RAC1<br/>Small GTPase"]
    HACE1["HACE1<br/>E3 Ubiquitin Ligase"]
    YAP["YAP<br/>Transcriptional<br/>Coactivator"]
    PIK3C3["PIK3C3<br/>Autophagy Regulator"]
    ATG14["ATG14<br/>Autophagy Gene"]
    GJA1["GJA1<br/>Gap Junction<br/>Protein"]
    LAMP1["LAMP1<br/>Lysosomal Protein"]
    
    ALS["Amyotrophic<br/>Lateral Sclerosis"]
    MS["Multiple<br/>Sclerosis"]
    PD["Parkinson's<br/>Disease"]
    Stroke["Stroke"]
    TBI["Traumatic<br/>Brain Injury"]
    Inflammation["Neuroinflammation"]
    
    Autophagy["Autophagy<br/>Dysfunction"]
    CellMigration["Cell Migration<br/> and Motility"]
    Neuroprotection["Neuroprotective<br/>Response"]
    
    HACE1 --|"regulates"|--> RAC1
    RAC1 --|"activates"|--> YAP
    RAC1 --|"regulates"|--> PIK3C3
    RAC1 --|"regulates"|--> ATG14
    RAC1 --|"regulates"|--> GJA1
    RAC1 --|"associates_with"|--> LAMP1
    
    PIK3C3 --|"promotes"|--> Autophagy
    ATG14 --|"promotes"|--> Autophagy
    LAMP1 --|"facilitates"|--> Autophagy
    
    RAC1 --|"promotes"|--> CellMigration
    YAP --|"enhances"|--> CellMigration
    
    RAC1 --|"inhibits"|--> TBI
    RAC1 --|"promotes"|--> Neuroprotection
    RAC1 --|"therapeutic_target"|--> ALS
    RAC1 --|"therapeutic_target"|--> MS
    RAC1 --|"therapeutic_target"|--> PD
    RAC1 --|"therapeutic_target"|--> Inflammation
    
    RAC1 --|"activates"|--> ALS
    RAC1 --|"activates"|--> Stroke
    Autophagy --|"contributes_to"|--> ALS
    Inflammation --|"worsens"|--> MS
    
    style RAC1 fill:#006494
    style HACE1 fill:#4a1a6b
    style PIK3C3 fill:#4a1a6b
    style ATG14 fill:#4a1a6b
    style Neuroprotection fill:#1b5e20
    style TBI fill:#ef5350
    style ALS fill:#ef5350
    style MS fill:#ef5350
    style Stroke fill:#ef5350
    style Inflammation fill:#ef5350
    style Autophagy fill:#5d4400
    style CellMigration fill:#5d4400