gene

CDC42

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDC42: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

423Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

CDC42 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, regulates. Associated with Aging, Als, Alzheimer. Connected to 206 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolCDC42
Full NameCell Division Cycle 42
Chromosome1p36.1
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight21 kDa
Amino Acids191 aa
Exons6
PathwaysProteasome, Ubiquitin-Proteasome
UniProt ID[P60953](https://www.uniprot.org/uniprot/P60953)
Ensembl IDENSG00000158062
GeneCardsCDC42
Human Protein AtlasCDC42
Associated DiseasesALS, Alzheimer, Diabetes, Ferroptosis, Inflammation
InteractionsATP5A1, SOD1, EGFR, RAB5, ACVR1, RGS2
KG Connections423 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

CDC42 Gene

gene · 1109 words

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

mechanism · 4664 words

dendritic-spines

mechanism · 4574 words

EPHA7 Gene

gene · 3390 words

Tunneling Nanotubes in Neurodegeneration

mechanism · 3387 words

EPHA6 — Ephrin Type-A Receptor 6

gene · 3363 words

Pathway Diagram

graph TD
    CDC42["CDC42"]
    CDC42 -->|"activates"| Cancer["Cancer"]
    CDC42 -->|"activates"| Aging["Aging"]
    CDC42 -->|"activates"| Ms["Ms"]
    CDC42 -->|"target for"| Inflammation["Inflammation"]
    CDC42 -->|"target for"| Parkinson["Parkinson"]
    CDC42 -->|"target for"| Diabetes["Diabetes"]
    CDC42 -->|"target for"| Alzheimer["Alzheimer"]
    STK11["STK11"] -->|"regulates"| CDC42
    PIK3C3["PIK3C3"] -->|"regulates"| CDC42
    MAP1LC3B["MAP1LC3B"] -->|"regulates"| CDC42
    OCLN["OCLN"] -->|"regulates"| CDC42
    VIM["VIM"] -->|"regulates"| CDC42
    LAMP1["LAMP1"] -->|"regulates"| CDC42
    HDAC6["HDAC6"] -->|"regulates"| CDC42
    MET["MET"] -->|"target for"| CDC42
    TPM2["TPM2"] -->|"target for"| CDC42
    CCT2["CCT2"] -->|"interacts"| CDC42

Outgoing (242)

TargetRelationTypeStr
Parkinson's Diseaseinvolved_indisease0.75
Canceractivatesdisease0.65
Agingactivatesdisease0.65
Msactivatesdisease0.65
Inflammationtherapeutic_targetdisease0.65

Incoming (181)

SourceRelationTypeStr
ACTBassociated_withgene0.60
SYNCRIPassociated_withgene0.60
SOD2associated_withgene0.60
STK11regulatesgene0.60
PIK3C3regulatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found