Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CDC42: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CDC42 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, regulates. Associated with Aging, Als, Alzheimer. Connected to 206 entities in the SciDEX knowledge graph.
| Gene Symbol | CDC42 |
| Full Name | Cell Division Cycle 42 |
| Chromosome | 1p36.1 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | 21 kDa |
| Amino Acids | 191 aa |
| Exons | 6 |
| Pathways | Proteasome, Ubiquitin-Proteasome |
| UniProt ID | [P60953](https://www.uniprot.org/uniprot/P60953) |
| Ensembl ID | ENSG00000158062 |
| GeneCards | CDC42 |
| Human Protein Atlas | CDC42 |
| Associated Diseases | ALS, Alzheimer, Diabetes, Ferroptosis, Inflammation |
| Interactions | ATP5A1, SOD1, EGFR, RAB5, ACVR1, RGS2 |
| KG Connections | 423 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
CDC42["CDC42"]
CDC42 -->|"activates"| Cancer["Cancer"]
CDC42 -->|"activates"| Aging["Aging"]
CDC42 -->|"activates"| Ms["Ms"]
CDC42 -->|"target for"| Inflammation["Inflammation"]
CDC42 -->|"target for"| Parkinson["Parkinson"]
CDC42 -->|"target for"| Diabetes["Diabetes"]
CDC42 -->|"target for"| Alzheimer["Alzheimer"]
STK11["STK11"] -->|"regulates"| CDC42
PIK3C3["PIK3C3"] -->|"regulates"| CDC42
MAP1LC3B["MAP1LC3B"] -->|"regulates"| CDC42
OCLN["OCLN"] -->|"regulates"| CDC42
VIM["VIM"] -->|"regulates"| CDC42
LAMP1["LAMP1"] -->|"regulates"| CDC42
HDAC6["HDAC6"] -->|"regulates"| CDC42
MET["MET"] -->|"target for"| CDC42
TPM2["TPM2"] -->|"target for"| CDC42
CCT2["CCT2"] -->|"interacts"| CDC42| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson's Disease | involved_in | disease | 0.75 |
| Cancer | activates | disease | 0.65 |
| Aging | activates | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Parkinson | therapeutic_target | disease | 0.65 |
| Diabetes | therapeutic_target | disease | 0.65 |
| Aging | interacts_with | disease | 0.65 |
| Cancer | interacts_with | disease | 0.65 |
| Alzheimer | therapeutic_target | disease | 0.65 |
| Huntington | therapeutic_target | disease | 0.65 |
| Parkinson | interacts_with | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Alzheimer | inhibits | disease | 0.65 |
| Als | inhibits | disease | 0.65 |
| Als | regulates | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Lymphoma | interacts_with | disease | 0.65 |
| Tumor | interacts_with | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Aging | stabilizes | disease | 0.65 |
| Cancer | stabilizes | disease | 0.65 |
| Parkinson | associated_with | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| Diabetes | associated_with | disease | 0.65 |
| Inflammation | expressed_in | disease | 0.65 |
| Prion | therapeutic_target | disease | 0.65 |
| Alzheimer | associated_with | disease | 0.65 |
| Ferroptosis | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Neurodegeneration | regulates | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Senescence | regulates | disease | 0.65 |
| Fibrosis | activates | disease | 0.65 |
| CASP3 | associated_with | gene | 0.60 |
| SQSTM1 | regulates | gene | 0.60 |
| TUBB3 | regulates | gene | 0.60 |
| STK11 | regulates | gene | 0.60 |
| VIM | regulates | gene | 0.60 |
| BECN1 | associated_with | gene | 0.60 |
| HDAC6 | regulates | gene | 0.60 |
| GAPDH | associated_with | gene | 0.60 |
| MAP1LC3B | regulates | gene | 0.60 |
| MAP3K5 | regulates | gene | 0.60 |
| UVRAG | regulates | gene | 0.60 |
| H2AX | associated_with | gene | 0.60 |
| OCLN | regulates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ACTB | associated_with | gene | 0.60 |
| SYNCRIP | associated_with | gene | 0.60 |
| SOD2 | associated_with | gene | 0.60 |
| STK11 | regulates | gene | 0.60 |
| PIK3C3 | regulates | gene | 0.60 |
| MAP1LC3B | regulates | gene | 0.60 |
| OCLN | regulates | gene | 0.60 |
| GJA1 | associated_with | gene | 0.60 |
| VIM | regulates | gene | 0.60 |
| LAMP1 | regulates | gene | 0.60 |
| HDAC6 | regulates | gene | 0.60 |
| MET | therapeutic_target | gene | 0.60 |
| TPM2 | therapeutic_target | gene | 0.60 |
| GFAP | associated_with | gene | 0.60 |
| NCF1 | associated_with | gene | 0.60 |
| VIM | associated_with | gene | 0.60 |
| MMP9 | associated_with | gene | 0.60 |
| CCT2 | interacts_with | gene | 0.60 |
| GFAP | interacts_with | gene | 0.60 |
| GRIA1 | interacts_with | gene | 0.60 |
| SNAP25 | interacts_with | gene | 0.60 |
| ACTG1 | interacts_with | gene | 0.60 |
| SNCA | interacts_with | gene | 0.60 |
| GAPDH | interacts_with | gene | 0.60 |
| MAPK1 | interacts_with | gene | 0.60 |
| PSMA3 | interacts_with | gene | 0.60 |
| SOX2 | interacts_with | gene | 0.60 |
| YWHAZ | interacts_with | gene | 0.60 |
| HSP90AB1 | interacts_with | gene | 0.60 |
| ACTB | interacts_with | gene | 0.60 |
| RAB7L1 | interacts_with | gene | 0.60 |
| ARHGEF7 | interacts_with | gene | 0.60 |
| RAC1 | interacts_with | gene | 0.60 |
| LRRK2 | interacts_with | gene | 0.60 |
| RGS2 | interacts_with | gene | 0.60 |
| RAC1 | inhibits | gene | 0.60 |
| LAMP1 | inhibits | gene | 0.60 |
| RHOA | inhibits | gene | 0.60 |
| APP | inhibits | gene | 0.60 |
| BCL2L1 | associated_with | gene | 0.60 |
| SRC | associated_with | gene | 0.60 |
| PI3K | therapeutic_target | gene | 0.60 |
| AKT | therapeutic_target | gene | 0.60 |
| HIF1A | associated_with | gene | 0.60 |
| RAB10 | activates | gene | 0.60 |
| RAB7A | activates | gene | 0.60 |
| PAK1 | associated_with | gene | 0.60 |
| PIK3CA | associated_with | gene | 0.60 |
| PTK2B | associated_with | gene | 0.60 |
| GATA2 | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||