gene

CDC42

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CDC42: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

418Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

2Debates

Summary

CDC42 is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, regulates. Associated with Aging, Als, Alzheimer. Connected to 206 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CDC42
Full Name	Cell Division Cycle 42
Chromosome	1p36.1
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	21 kDa
Amino Acids	191 aa
Exons	6
Pathways	Proteasome, Ubiquitin-Proteasome
UniProt ID	[P60953](https://www.uniprot.org/uniprot/P60953)
Ensembl ID	ENSG00000158062
GeneCards	CDC42
Human Protein Atlas	CDC42
GTP-Binding Domain	Five conserved motifs (GxxxxGKST, DxxG, TxxxGKST, xDxx, CAAX box)
Switch I Region	Residues 32-45, conformational change on GTP/GDP binding
Switch II Region	Residues 60-76, effector interaction site
Associated Diseases	Als, Alzheimer, Diabetes, Ferroptosis, Inflammation
Interactions	ACTB, ACTG1, Actin, ACVR1, AGING, AKT
KG Connections	418 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CDC42["CDC42"]
    CDC42 -->|"activates"| Cancer["Cancer"]
    CDC42 -->|"activates"| Aging["Aging"]
    CDC42 -->|"activates"| Ms["Ms"]
    CDC42 -->|"target for"| Inflammation["Inflammation"]
    CDC42 -->|"target for"| Parkinson["Parkinson"]
    CDC42 -->|"target for"| Diabetes["Diabetes"]
    CDC42 -->|"target for"| Alzheimer["Alzheimer"]
    STK11["STK11"] -->|"regulates"| CDC42
    PIK3C3["PIK3C3"] -->|"regulates"| CDC42
    MAP1LC3B["MAP1LC3B"] -->|"regulates"| CDC42
    OCLN["OCLN"] -->|"regulates"| CDC42
    VIM["VIM"] -->|"regulates"| CDC42
    LAMP1["LAMP1"] -->|"regulates"| CDC42
    HDAC6["HDAC6"] -->|"regulates"| CDC42
    MET["MET"] -->|"target for"| CDC42
    TPM2["TPM2"] -->|"target for"| CDC42
    CCT2["CCT2"] -->|"interacts"| CDC42

Outgoing (238)

Target	Relation	Type	Str
Parkinson's Disease	involved_in	disease	0.75
cytoskeletal remodeling	regulates	phenotype	0.70
Tumor	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Lymphoma	interacts_with	disease	0.65
Aging	activates	disease	0.65
Ms	activates	disease	0.65
Prion	therapeutic_target	disease	0.65
Aging	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	activates	disease	0.65
Cancer	therapeutic_target	disease	0.65
Als	associated_with	disease	0.65
Aging	stabilizes	disease	0.65
Cancer	stabilizes	disease	0.65
Ferroptosis	associated_with	disease	0.65
Neurodegeneration	regulates	disease	0.65
Als	regulates	disease	0.65
Alzheimer	associated_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Parkinson	associated_with	disease	0.65
Inflammation	associated_with	disease	0.65
Diabetes	associated_with	disease	0.65
Senescence	regulates	disease	0.65
Fibrosis	activates	disease	0.65
Als	inhibits	disease	0.65
Alzheimer	inhibits	disease	0.65
Huntington	therapeutic_target	disease	0.65
Alzheimer	therapeutic_target	disease	0.65
Diabetes	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
ALS	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Inflammation	expressed_in	disease	0.65
Inflammation	therapeutic_target	disease	0.65
ACTG1	interacts_with	gene	0.60
YWHAZ	interacts_with	gene	0.60
JAK2	regulates	gene	0.60
TPR	associated_with	gene	0.60
neurodegeneration	activates	disease	0.60
EGFR	interacts_with	gene	0.60
MET	associated_with	gene	0.60
TUBULIN	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
HSP90AB1	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60

Incoming (180)

Source	Relation	Type	Str
WNT_SIGNALING	activates	pathway	0.70
RAC1	associated_with	gene	0.60
CYCS	associated_with	gene	0.60
TPM2	associated_with	gene	0.60
CYP11A1	associated_with	gene	0.60
ALZHEIMER	inhibits	gene	0.60
SRC	associated_with	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
HIF1A	associated_with	gene	0.60
MAP2K1	associated_with	gene	0.60
ANGPT1	associated_with	gene	0.60
RHOA	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
RAF1	associated_with	gene	0.60
TUBULIN	regulates	gene	0.60
P62	regulates	gene	0.60
MAP3K5	regulates	gene	0.60
UBIQUITIN	regulates	gene	0.60
SQSTM1	regulates	gene	0.60
CASP3	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
TUBB3	regulates	gene	0.60
UVRAG	regulates	gene	0.60
RAC1	regulates	gene	0.60
SOD1	interacts_with	gene	0.60
KIF15	associated_with	gene	0.60
NEFL	associated_with	gene	0.60
AURKB	associated_with	gene	0.60
TPR	associated_with	gene	0.60
RANK	therapeutic_target	gene	0.60
CALM1	associated_with	gene	0.60
NEFH	associated_with	gene	0.60
KIF5B	associated_with	gene	0.60
SYNCRIP	causes	gene	0.60
ALZHEIMER'S DISEASE	therapeutic_target	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
AMYLOID-BETA	inhibits	gene	0.60
ENDOSOMES	inhibits	gene	0.60
AUTOPHAGY	associated_with	gene	0.60
PARKINSON	therapeutic_target	gene	0.60
HUNTINGTON	therapeutic_target	gene	0.60
DENND3	therapeutic_target	gene	0.60
ARF6	associated_with	gene	0.60
AMYLOID	inhibits	gene	0.60
BCL2L1	associated_with	gene	0.60
AND	regulates	gene	0.60
PIK3C3	regulates	gene	0.60
MAP1LC3B	regulates	gene	0.60
OCLN	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

4R-tau strain-specific spreading patterns in PSP vs CBD

neurodegeneration | 2026-04-01 | 14 hypotheses Top: 0.732

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns

closed · Rounds: 4 · Score: 0.69 · 2026-04-12

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns

closed · Rounds: 7 · Score: 0.91 · 2026-04-10

Related Research

Hypotheses and analyses mentioning CDC42 in their description or question text

No additional research found

CDC42

Understanding Entity Pages

Summary

Wiki Pages (3)

CDC42 Gene

CDC42EP2 Gene

CDC42EP1 Gene

Pathway Diagram

Outgoing (238)

Incoming (180)

Targeting Hypotheses (0)

Mentioning Analyses (1)

4R-tau strain-specific spreading patterns in PSP vs CBD

Experiments (0)

Related Papers (0)

Debates (2)

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns

PSP and CBD both involve 4R-tau but produce distinct neuropathological patterns

Related Research