gene

ZNF7

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ZNF7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

10Connections

0Hypotheses

0Analyses

8Outgoing

2Incoming

0Experiments

0Debates

Summary

Comprehensive gene page for ZNF7, a KRAB-type zinc finger transcription factor with roles in gene repression and potential implications in neurodegenerative diseases.

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🧬 Gene Info

Gene Symbol	ZNF7
Full Name	Zinc Finger Protein 7
Chromosome	8q24.21
Protein Type	Transcription Factor
Function	ZNF7 (Zinc Finger Protein 7), also known as ZNF45 or KOX15, is a C2H2-type zinc finger transcription factor that belongs to the Krüppel-associated box (KRAB) family [1]
Amino Acids	650 aa
Pathways	Inflammasome, Innate Immunity
Ensembl ID	ENSG00000124783
GeneCards	ZNF7
Human Protein Atlas	ZNF7
KRAB domain	Located at the N-terminus (approximately 100 amino acids), consisting of two subdomains (A and B) that mediate transcriptional repression
Zinc finger domain	Contains 15 C2H2-type zinc fingers at the C-terminus, each approximately 30 amino acids in length
Nuclear localization signals	Present within the zinc finger region
Associated Diseases	neurodegeneration
Interactions	UBIQUITIN, INFLAMMATION
KG Connections	10 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    N0["ZNF7"]
    N1["Inflammation"]
    N0 -->|"activates"| N1
    N2["INFLAMMATION"]
    N0 -->|"activates"| N2
    N3["UBIQUITIN"]
    N0 -->|"activates"| N3
    N4["Innate Immunity"]
    N0 -->|"activates"| N4
    N5["Inflammasome"]
    N0 -->|"activates"| N5
    N0 -->|"degrades"| N5
    N0 -->|"degrades"| N4
    N6["Macrophage"]
    N0 -->|"degrades"| N6
    N7["NEK7"]
    N7 -->|"associated with"| N0
    N8["NLRP3"]
    N8 -->|"associated with"| N0
    N9["neurodegeneration"]
    N0 -->|"implicated in"| N9

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 gene
    class N3 gene
    class N4 pathway
    class N5 pathway
    class N7 gene
    class N8 gene

Outgoing (8)

Target	Relation	Type	Str
Inflammation	activates	disease	0.65
UBIQUITIN	activates	gene	0.60
INFLAMMATION	activates	gene	0.60
Innate Immunity	activates	pathway	0.60
Inflammasome	activates	pathway	0.60
Inflammasome	degrades	pathway	0.60
Innate Immunity	degrades	pathway	0.60
Macrophage	degrades	cell_type	0.60

Incoming (2)

Source	Relation	Type	Str
NEK7	associated_with	gene	0.60
NLRP3	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity