Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about als4-alsine: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ALS4 |
| Aliases | als4-alsine |
| Chromosome | 11q13.2 |
| Function | The ALS4 gene (Alsin) encodes the Alsin protein, a multifunctional Rab5 guanine nucleotide exchange factor (GEF) critical for endosomal trafficking, mitochondrial function, and neuronal survival |
| Primary Expression | Highest in motor neurons, brain, spinal cord |
| Molecular Weight | ~185 kDa |
| Amino Acids | 1648 aa |
| UniProt ID | Q9UQB8 |
| NCBI Gene ID | 7080 |
| GeneCards | ALS4 |
| Human Protein Atlas | ALS4 |
| Associated Diseases | Amyotrophic Lateral Sclerosis, Dementia, Als, Ataxia, Frontotemporal Dementia, Ftd |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
A["Gene expression"] --> B["als4 alsine"]
B --> C["Protein folding and<br/>quality control"]
B --> D["Cellular signaling"]
C --> E["Proteostasis"]
D --> F["Neurotoxicity"]
E --> G["Disease outcome"]
F --> G
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class B protein
class G disease| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||