disease

Ftd

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Ftd: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

903Connections

2Hypotheses

6Analyses

40Outgoing

50Incoming

Summary

Ftd is a disease characterized by neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with Als, Ftld. Connected to 190 entities in the SciDEX knowledge graph.

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Disease Info

Associated Genes	LDLR, LRP1, LRP1B, LRP2, LRP4, LRP5, LRP8, PAH
KG Connections	385 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Clinical Management Guide for CBS/PSP

therapeutic · 15224 words

→

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

→

Pathway Diagram

graph TD
    Ftd["Ftd"] -->|"interacts"| Autophagy["Autophagy"]
    Ftd["Ftd"] -->|"regulates"| Oxidative_Stress["Oxidative Stress"]
    Ftd["Ftd"] -->|"interacts"| Apoptosis["Apoptosis"]
    Ftd["Ftd"] -->|"interacts"| Cell_Cycle["Cell Cycle"]
    Ftd["Ftd"] -->|"interacts"| Mapk["Mapk"]
    Ftd["Ftd"] -->|"therapeutic target"| Mitophagy["Mitophagy"]
    ACTB["ACTB"] -->|"interacts"| Ftd["Ftd"]
    BECN1["BECN1"] -->|"interacts"| Ftd["Ftd"]
    C9ORF72["C9ORF72"] -->|"interacts"| Ftd["Ftd"]
    CALCOCO2["CALCOCO2"] -->|"interacts"| Ftd["Ftd"]
    style Ftd fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (284)

Target	Relation	Type	Str
Autophagy	interacts_with	pathway	0.55
Oxidative Stress	regulates	pathway	0.55
Apoptosis	interacts_with	pathway	0.55
Cell Cycle	interacts_with	pathway	0.55
Mapk	interacts_with	pathway	0.55
Mitophagy	therapeutic_target	pathway	0.55
Lipid Metabolism	associated_with	pathway	0.55
Wnt	associated_with	pathway	0.55
Akt	associated_with	pathway	0.55
Autophagy	associated_with	pathway	0.55
Complement	associated_with	pathway	0.55
Mapk	associated_with	pathway	0.55
Mtor	associated_with	pathway	0.55
Pi3K	associated_with	pathway	0.55
Protein Aggregation	associated_with	pathway	0.55
Autophagy	activates	pathway	0.55
Mtor	activates	pathway	0.55
Proteasome	activates	pathway	0.55
Ubiquitin-Proteasome	activates	pathway	0.55
Unfolded Protein Response	activates	pathway	0.55
Complement	regulates	pathway	0.55
Autophagy	regulates	pathway	0.55
Amyloid	expressed_in	pathway	0.55
Phagocytosis	expressed_in	pathway	0.55
Inflammasome	expressed_in	pathway	0.55
Protein Aggregation	regulates	pathway	0.55
Akt	causes	pathway	0.55
Akt	therapeutic_target	pathway	0.55
Wnt	therapeutic_target	pathway	0.55
Protein Aggregation	therapeutic_target	pathway	0.55
Pi3K	therapeutic_target	pathway	0.55
Mtor	therapeutic_target	pathway	0.55
Complement	therapeutic_target	pathway	0.55
Mapk	therapeutic_target	pathway	0.55
Autophagy	therapeutic_target	pathway	0.55
Immune Response	activates	pathway	0.55
Necroptosis	causes	pathway	0.55
Autophagy	causes	pathway	0.55
Phagocytosis	activates	pathway	0.55
Jak-Stat	activates	pathway	0.55

Incoming (619)

Source	Relation	Type	Str
C9ORF72	risk_factor_for	gene	0.95
Als	associated_with	disease	0.90
Ftld	associated_with	disease	0.90
ACTB	interacts_with	gene	0.65
BECN1	interacts_with	gene	0.65
C9ORF72	interacts_with	gene	0.65
CALCOCO2	interacts_with	gene	0.65
FUS	interacts_with	gene	0.65
G3BP1	interacts_with	gene	0.65
LC3	interacts_with	gene	0.65
MAP1LC3	interacts_with	gene	0.65
NBR1	interacts_with	gene	0.65
NDP52	interacts_with	gene	0.65
OPTN	interacts_with	gene	0.65
P62	interacts_with	gene	0.65
SMCR8	interacts_with	gene	0.65
SQSTM1	interacts_with	gene	0.65
TAX1BP1	interacts_with	gene	0.65
TOLLIP	interacts_with	gene	0.65
ULK1	interacts_with	gene	0.65
ABCD3	interacts_with	gene	0.65
AMBRA1	interacts_with	gene	0.65
AMPK	interacts_with	gene	0.65
ATG	interacts_with	gene	0.65
ATM	interacts_with	gene	0.65
BCL2	interacts_with	gene	0.65
BCL2L11	interacts_with	gene	0.65
BCL2L13	interacts_with	gene	0.65
BNIP3	interacts_with	gene	0.65
BNIP3L	interacts_with	gene	0.65
CANX	interacts_with	gene	0.65
CAT	interacts_with	gene	0.65
CHOP	interacts_with	gene	0.65
CTSD	interacts_with	gene	0.65
DDIT3	interacts_with	gene	0.65
DISC1	interacts_with	gene	0.65
DNM1L	interacts_with	gene	0.65
DRP1	interacts_with	gene	0.65
EIF2AK3	interacts_with	gene	0.65
EIF2S1	interacts_with	gene	0.65
EMD	interacts_with	gene	0.65
EPAS1	interacts_with	gene	0.65
ERN1	interacts_with	gene	0.65
FAM134B	interacts_with	gene	0.65
FIP200	interacts_with	gene	0.65
FMR1	interacts_with	gene	0.65
FUNDC1	interacts_with	gene	0.65
GBA	interacts_with	gene	0.65
HIF1	interacts_with	gene	0.65
HIF1A	interacts_with	gene	0.65

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Stathmin-2 Splice Switching to Prevent Axonal Degeneration A	0.664	neurodegeneration	RNA binding protein dysregulation across
Microglial AIM2 Inflammasome as the Primary Driver of TDP-43	0.601	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (6)

Scientific analyses that reference this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Ftd

Understanding Entity Pages

Summary

Wiki Pages (21)

Frontal Cortex Layer 2 Neurons in Frontotemporal Dementia

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Pathway Diagram

Outgoing (284)

Incoming (619)

Targeting Hypotheses (2)

Mentioning Analyses (6)

How does FUS loss-of-function in TAZ regulation contribute to ALS/FTD pathogenes

RNA binding protein dysregulation across ALS FTD AD

How do pathological stress granules in neurodegeneration escape TRIM21/autophagy

RNA binding protein dysregulation across ALS FTD and AD

TDP-43 phase separation therapeutics for ALS-FTD

RNA binding protein dysregulation across ALS FTD and AD

Related Papers (0)

Ftd

Understanding Entity Pages

Summary

Wiki Pages (21)

Frontal Cortex Layer 2 Neurons in Frontotemporal Dementia

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

Parkinson's Disease

primary-progressive-aphasia

calcium-dysregulation-comparison

Corticobasal Degeneration (CBD)

nimodipine-als

Therapeutics

NPM1 Gene

Section 162: Advanced Antioxidant and Redox Therapy in CBS/PSP

Frontotemporal Dementia (FTD) Mechanistic Pathway

neuroinflammation

Frontotemporal Dementia (FTD)

Microglial Cells — Cell Type Hierarchy

TREM2 Mechanism Hub

Pathway Diagram

Outgoing (284)

Incoming (619)

Targeting Hypotheses (2)

Mentioning Analyses (6)

How does FUS loss-of-function in TAZ regulation contribute to ALS/FTD pathogenes

RNA binding protein dysregulation across ALS FTD AD

How do pathological stress granules in neurodegeneration escape TRIM21/autophagy

RNA binding protein dysregulation across ALS FTD and AD

TDP-43 phase separation therapeutics for ALS-FTD

RNA binding protein dysregulation across ALS FTD and AD

Related Papers (0)