concept

COMPLEMENT SYSTEM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about COMPLEMENT SYSTEM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

147Connections

1Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

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💡 Concept Info

Name	COMPLEMENT SYSTEM

Pathway Diagram

graph TD
    COMPLEMENT_SYSTEM["COMPLEMENT SYSTEM"]
    style COMPLEMENT_SYSTEM fill:#1a237e,stroke:#4fc3f7,stroke-width:3px
    COMPLEMENT_SYSTEM -->|"contributes to"| Alzheimer_s_Disease["Alzheimer's Disease"]
    COMPLEMENT_SYSTEM -->|"modulates"| Cancer_Progression["Cancer Progression"]
    COMPLEMENT_SYSTEM -->|"causes"| Paroxysmal_Nocturnal_Hemoglobi["Paroxysmal Nocturnal Hemoglobinuria"]
    COMPLEMENT_SYSTEM -->|"mediates"| Synaptic_Pruning["Synaptic Pruning"]
    COMPLEMENT_SYSTEM -->|"contributes to"| Amyloid_Beta_Accumulation["Amyloid-Beta Accumulation"]
    COMPLEMENT_SYSTEM -->|"contributes to"| Neuroinflammation["Neuroinflammation"]
    COMPLEMENT_SYSTEM -->|"mediates"| Neurodegeneration["Neurodegeneration"]
    COMPLEMENT_SYSTEM -->|"mediates"| Microglial_Synaptic_Eliminatio["Microglial Synaptic Elimination"]
    COMPLEMENT_SYSTEM -->|"contributes to"| Synapse_Loss(Synapse Loss)
    COMPLEMENT_SYSTEM -->|"contributes to"| Blood_Brain_Barrier_Disruption(Blood-Brain Barrier Disruption)
    NETosis["NETosis"] -->|"interacts"| COMPLEMENT_SYSTEM
    C1QA([C1QA]) -->|"involved_in"| COMPLEMENT_SYSTEM
    C1Q([C1Q]) -->|"interacts"| COMPLEMENT_SYSTEM
    COMPLEMENT([COMPLEMENT]) -->|"interacts"| COMPLEMENT_SYSTEM
    NEURON([NEURON]) -->|"expressed in"| COMPLEMENT_SYSTEM
    B4GANLT1([B4GANLT1]) -->|"expressed in"| COMPLEMENT_SYSTEM
    ST8SIA1([ST8SIA1]) -->|"expressed in"| COMPLEMENT_SYSTEM
    GFAP([GFAP]) -->|"expressed in"| COMPLEMENT_SYSTEM
    DNA([DNA]) -->|"expressed in"| COMPLEMENT_SYSTEM
    CYTOKINES([CYTOKINES]) -->|"expressed in"| COMPLEMENT_SYSTEM

Outgoing (53)

Target	Relation	Type	Str
Synaptic Plasticity	involved_in	process	0.95
Cns Immune Surveillance	involved_in	process	0.95
Debris Clearance	involved_in	process	0.95
Alzheimer's Disease	contributes_to	disease	0.95
ALZHEIMER'S DISEASE	contributes_to	disease	0.95
Cancer Progression	modulates	process	0.95
NEUROINFLAMMATION	contributes_to	process	0.90
Neurodegeneration	mediates	process	0.90
Cancer Immunotherapy	targets	process	0.90
Visual System Degeneration	associated_with	phenotype	0.90
Neuroinflammation	contributes_to	process	0.90
Amyloid-Beta Accumulation	contributes_to	process	0.90
Synaptic Pruning	mediates	process	0.90
Neurodegeneration	associated_with	process	0.85
Synapse Loss	contributes_to	phenotype	0.85
Blood-Brain Barrier Disruption	contributes_to	phenotype	0.85
Cerebral Amyloid Angiopathy	contributes_to	disease	0.85
Neurodegeneration	protects_against	disease	0.85
Malignant Cells	interacts_with	cell_type	0.85
Microglial Synaptic Elimination	mediates	process	0.85
Innate Immune Memory	modulates	process	0.85
Innate Immune Memory	interacts_with	process	0.85
NEURODEGENERATION	promotes	process	0.85
Blood-Brain Barrier Disruption	promotes	phenotype	0.85
Opsonophagocytosis	mediates	process	0.80
optic nerve degeneration	contributes_to	process	0.75
Alzheimer's disease	implicated_in	disease	0.70
Synaptic pruning	activates	pathway	0.60
Stem Cell	regulates	cell_type	0.50
Macrophage	associated_with	cell_type	0.50
Neutrophil	contributes_to	cell_type	0.50
Neuron	contributes_to	cell_type	0.50
Microglia	inhibits	cell_type	0.50
Astrocyte	inhibits	cell_type	0.50
Macrophage	inhibits	cell_type	0.50
T Cell	therapeutic_target	cell_type	0.50
Microglia	contributes_to	cell_type	0.50
Astrocyte	contributes_to	cell_type	0.50
T Cell	contributes_to	cell_type	0.50
Neuron	expressed_in	cell_type	0.50
Microglia	regulates	cell_type	0.50
Microglia	therapeutic_target	cell_type	0.50
Astrocyte	therapeutic_target	cell_type	0.50
Monocyte	therapeutic_target	cell_type	0.50
Endothelial	therapeutic_target	cell_type	0.50
Microglia	activates	cell_type	0.50
Neuron	activates	cell_type	0.50
Macrophage	activates	cell_type	0.50
Mast Cell	therapeutic_target	cell_type	0.50
Macrophage	therapeutic_target	cell_type	0.50

Incoming (94)

Source	Relation	Type	Str
C1Q	associated_with	gene	0.90
CLU	inhibits	protein	0.85
GANGLIOSIDE	activates	compound	0.80
DNA	associated_with	gene	0.60
PSEN1	associated_with	gene	0.60
MICRORNAS	regulates	gene	0.60
AMYLOID	regulates	gene	0.60
AGING	regulates	gene	0.60
ALZHEIMER	associated_with	gene	0.60
COMPLEMENT	associated_with	gene	0.60
SYNAPSE	regulates	gene	0.60
39272998	is a potential target for	paper	0.60
GLAUCOMA	activates	gene	0.60
CFB	activates	gene	0.60
39272998	is a potential target in	paper	0.60
PSEN2	associated_with	gene	0.60
PRESENILIN	associated_with	gene	0.60
B4GANLT1	expressed_in	gene	0.60
ST8SIA1	expressed_in	gene	0.60
GFAP	expressed_in	gene	0.60
DNA	expressed_in	gene	0.60
CYTOKINES	expressed_in	gene	0.60
COMPLEMENT	activates	gene	0.60
AGING	expressed_in	gene	0.60
NEURON	expressed_in	gene	0.60
CD47	regulates	gene	0.60
C1R	regulates	gene	0.60
SIRPA	regulates	gene	0.60
MERTK	regulates	gene	0.60
COMPLEMENT	regulates	gene	0.60
C1QB	regulates	gene	0.60
C1S	regulates	gene	0.60
ASTROCYTES	therapeutic_target	gene	0.60
C1QA	therapeutic_target	gene	0.60
GLAUCOMA	therapeutic_target	gene	0.60
ASTROCYTES	contributes_to	gene	0.60
MICROGLIA	contributes_to	gene	0.60
ASTROCYTE	inhibits	gene	0.60
SYNAPSE	inhibits	gene	0.60
C1Q	activates	gene	0.60
C1QA	regulates	gene	0.60
C1QC	regulates	gene	0.60
ITGAM	regulates	gene	0.60
AGING	associated_with	gene	0.60
DEPRESSION	activates	gene	0.60
MICROGLIA	activates	gene	0.60
SYNAPSE	activates	gene	0.60
AGING	activates	gene	0.60
MICROGLIA	therapeutic_target	gene	0.60
CYTOKINES	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Ancestry-Specific Complement System Calibration	0.000	-	How do neurodegeneration gene expression

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning COMPLEMENT SYSTEM in their description or question text

No additional research found