Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about arx: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ARX |
| Full Name | Aristaless-Related Homeobox |
| Chromosome | Xp21.3 |
| Protein Type | Transcription Factor |
| Function | ARX plays critical roles in development and function |
| Amino Acids | 60 aa |
| Gene Type | Protein coding |
| UniProt ID | Q9NUJ1 |
| NCBI Gene ID | 566 |
| Ensembl ID | ENSG00000031081 |
| OMIM | 300382 |
| GeneCards | ARX |
| Human Protein Atlas | ARX |
| Associated Diseases | Als, neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["ARX"]
N1["Als"]
N0 -->|"associated with"| N1
N2["Ms"]
N0 -->|"regulates"| N2
N3["GENES"]
N0 -->|"interacts with"| N3
N4["PER"]
N0 -->|"associated with"| N4
N5["Differentiation"]
N0 -->|"associated with"| N5
N6["Synaptic Plasticity"]
N0 -->|"associated with"| N6
N7["FMR1"]
N7 -->|"interacts with"| N0
N8["neurodegeneration"]
N0 -->|"implicated in"| N8
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef therapeutic fill:#1a2a2a,stroke:#26a69a,color:#e0e0e0
class N1 disease
class N2 disease
class N3 gene
class N4 gene
class N5 pathway
class N6 pathway
class N7 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Als | associated_with | disease | 0.65 |
| Ms | regulates | disease | 0.65 |
| GENES | interacts_with | gene | 0.60 |
| PER | associated_with | gene | 0.60 |
| Differentiation | associated_with | pathway | 0.60 |
| Synaptic Plasticity | associated_with | pathway | 0.60 |
| benchmark_ot_ad_answer_key:ARX | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FMR1 | interacts_with | gene | 0.60 |
| benchmark_ot_ad_answer_key:ARX | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||