Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HIGH-FAT DIET: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | HIGH-FAT DIET |
Knowledge base pages for this entity
graph TD
HIGH_FAT_DIET["HIGH-FAT DIET"]
HIGH_FAT_DIET -->|"causes"| Obesity["Obesity"]
HIGH_FAT_DIET -->|"causes"| Metabolic_Disorders["Metabolic Disorders"]
HIGH_FAT_DIET -->|"upregulates"| Body_Weight["Body Weight"]
HIGH_FAT_DIET -->|"causes"| Non_Alcoholic_Fatty_Liver_Dise["Non-Alcoholic Fatty Liver Disease"]
HIGH_FAT_DIET -->|"downregulates"| Locomotor_Activity["Locomotor Activity"]
HIGH_FAT_DIET -->|"causes"| Neuroinflammation["Neuroinflammation"]
HIGH_FAT_DIET -->|"causes"| Neutrophil_Reprogramming["Neutrophil Reprogramming"]
HIGH_FAT_DIET -->|"downregulates"| Autophagy["Autophagy"]| Target | Relation | Type | Str |
|---|---|---|---|
| Metabolic Disorders | causes | disease | 0.95 |
| Body Weight | upregulates | biomarker | 0.95 |
| Non-Alcoholic Fatty Liver Disease | causes | disease | 0.95 |
| Hippocampal Neurogenesis | inhibits | process | 0.95 |
| Obesity | causes | disease | 0.95 |
| Locomotor Activity | downregulates | phenotype | 0.90 |
| Neutrophil Reprogramming | causes | process | 0.90 |
| Metabolic Stress | causes | process | 0.90 |
| Neuroinflammation | associated_with | process | 0.90 |
| Neuroinflammation | causes | process | 0.90 |
| Cognitive Decline | causes | phenotype | 0.90 |
| Autophagy Dysfunction | causes | process | 0.88 |
| Autophagy | downregulates | process | 0.88 |
| TREM2 | promotes | gene | 0.87 |
| TNF-Α production | promotes | process | 0.87 |
| Memory Impairment | causes | phenotype | 0.85 |
| Spatial Learning | associated_with | phenotype | 0.85 |
| Fat Mass Accumulation | promotes | phenotype | 0.85 |
| Glutathione | upregulates | compound | 0.85 |
| Cognitive Impairment | causes | phenotype | 0.85 |
| Alzheimer's Disease | risk_factor_for | disease | 0.85 |
| Oxidative Stress | causes | process | 0.85 |
| Anxiety-Like Behavior | associated_with | phenotype | 0.80 |
| neuroinflammation | induces | process | 0.80 |
| Microglia Dysregulation | causes | phenotype | 0.80 |
| Fear Conditioning | associated_with | phenotype | 0.80 |
| Alzheimer'S Disease | risk_factor_for | disease | 0.80 |
| CLOCK | regulates | gene | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||