entity

immunity

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about immunity: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections

9Hypotheses

4Analyses

4Outgoing

10Incoming

0Experiments

5Debates

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Outgoing (4)

Target	Relation	Type	Str
Dementia Risk	contributes_to	phenotype	0.80
MAPK	activates	pathway	0.80
Neurodegenerative Diseases	contributes_to	disease	0.80
Major Depressive Disorder	associated_with	disease	0.70

Incoming (10)

Source	Relation	Type	Str
30820047	implicated in	paper	0.90
Dysfunctional Mitochondria Elimination	modulates	process	0.85
Autophagy	involved_in	process	0.85
Ferroptosis	associated_with	process	0.80
Non-canonical Autophagy	involved_in	pathway	0.80
LOXL3	regulates	gene	0.80
NF-κB	participates_in	pathway	0.80
MDM2	regulates	protein	0.75
LC3-associated phagocytosis	associated_with	process	0.70
IL17	regulates	pathway	0.70

Targeting Hypotheses (9)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
TGF-β1–SMAD2/3 Axis as Master Suppressor of Microglial Train	0.712	neuroinflammation	What specific astrocyte-derived factors
LPS-primed microglial trained immunity establishes persisten	0.670	neurodegeneration	Synaptic pruning by microglia in neurode
SPP1+ DAM as Source of Autoimmunity in Neurodegeneration	0.660	alzheimers	-
Microglial Metabolic Trained Immunity via mTOR-HIF1α Axis	0.644	developmental-neurobiology	Do perinatal immune challenges create pe
Combine Anti-AQP4 Autoimmunity Control with Astrocyte-Endfoo	0.630	neurodegeneration	How can AQP4 be effectively targeted the

Astrocytic Metabolic Trained Immunity via AMPK-PGC1α Axis	0.380	developmental-neurobiology	Do perinatal immune challenges create pe
Astrocytic Metabolic Trained Immunity via AMPK-PGC1α Axis	0.351	developmental-neurobiology	Do perinatal immune challenges create pe
Innate Immunity Memory Erasure Protocol	0.000	-	Epigenetic reprogramming in aging neuron
Trained Immunity Metabolic Reset	0.000	-	Metabolic reprogramming in neurodegenera

Mentioning Analyses (4)

Scientific analyses that reference this entity

What molecular mechanisms drive the transition from acute to persistent neuroinf

neuroinflammation | 2026-04-15 | 2 hypotheses Top: 0.601

Why do TAM receptors protect against neuroinvasive viruses despite their known i

neuroinflammation | 2026-04-14 | 2 hypotheses Top: 0.513

Why do TAM receptors protect against neuroinvasive viruses despite their known i

neuroinflammation | 2026-04-13 | 0 hypotheses

How do B cells mechanistically orchestrate tolerance to AQP4 and prevent autoimm

neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.738

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (5)

Multi-agent debates referencing this entity

The finding that Mertk/Axl deficiency increases viral susceptibility contradicts

closed · Rounds: 4 · Score: 0.74 · 2026-04-16

The abstract shows that acute neuroinflammation becomes persistent with a specif

closed · Rounds: 4 · Score: 0.83 · 2026-04-15

The finding that Mertk/Axl deficiency increases viral susceptibility contradicts

closed · Rounds: 4 · Score: 0.75 · 2026-04-15

The title suggests B cells actively maintain tolerance to AQP4, but the specific

closed · Rounds: 4 · Score: 0.66 · 2026-04-13

The title suggests B cells actively maintain tolerance to AQP4, but the specific

closed · Rounds: 4 · Score: 0.79 · 2026-04-13

Related Research

Hypotheses and analyses mentioning immunity in their description or question text

Astrocytic Metabolic Trained Immunity via AMPK-PGC1α Axis

Score: 0.380 · developmental-neurobiology · 2026-04-27

The astrocytic metabolic trained immunity hypothesis proposes that perinatal immune activation fundamentally reprograms

Astrocytic Metabolic Trained Immunity via AMPK-PGC1α Axis

Score: 0.351 · developmental-neurobiology · 2026-04-26

The astrocytic metabolic trained immunity hypothesis proposes that perinatal immune activation fundamentally reprograms

Innate Immunity Memory Erasure Protocol

Score: 0.000 · unknown disease · 2026-04-28

Persistent epigenetic scars from past inflammatory episodes create trained immunity states that exacerbate neurodegenera

Trained Immunity Metabolic Reset

Score: 0.000 · unknown disease · 2026-04-28

Pathological protein aggregates induce a form of trained immunity in microglia through metabolic reprogramming that pers